KEGG   DRUG: Guanfacine hydrochloride
Entry
D00606                      Drug                                   
Name
Guanfacine hydrochloride (JAN/USP);
Intuniv (TN);
Tenex (TN)
Product
  Generic
Formula
C9H9Cl2N3O. HCl
Exact mass
280.9889
Mol weight
282.5542
Structure
Simcomp
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Therapeutic category: 1179
ATC code: C02AC02
Chemical structure group: DG00250
Product (DG00250): D00606<JP/US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Hypertension [DS:H01633]
Comment
Guanidine derivative
Target
ADRA2A [HSA:150] [KO:K04138]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC02 Guanfacine
      D00606  Guanfacine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00606  Guanfacine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00250  Guanfacine
    D00606  Guanfacine hydrochloride
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00250  Guanfacine
      D00606  Guanfacine hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00250  Guanfacine
     D00606  Guanfacine hydrochloride
  DG02925  CYP3A5 substrate
   DG00250  Guanfacine
    D00606  Guanfacine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2A
     D00606  Guanfacine hydrochloride (JAN/USP) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00606
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00606
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00606
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00250  Guanfacine
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00250  Guanfacine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00250  Guanfacine
  DG02925  CYP3A5 substrate
   DG00250  Guanfacine
Other DBs
CAS: 29110-48-3
PubChem: 7847672
ChEBI: 5559
LigandBox: D00606
NIKKAJI: J262.680B
LinkDB
KCF data

ATOM        16
            1   C8y C    24.2186  -16.1239
            2   C1b C    23.0015  -15.4193
            3   C8y C    24.2070  -17.5156
            4   C8y C    25.4239  -15.4134
            5   C5a C    21.7961  -16.1239
            6   C8x C    25.4239  -18.2144
            7   X   Cl   22.9956  -18.2087
            8   C8x C    26.6353  -16.1122
            9   X   Cl   25.4182  -14.0101
            10  N1b N    20.5848  -15.4193
            11  O5a O    21.7961  -17.5215
            12  C8x C    26.6353  -17.5156
            13  C2c C    19.3677  -16.1239
            14  N1a N    18.1565  -15.4193
            15  N2a N    19.3677  -17.5215
            16  X   Cl   29.0752  -16.4966
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 2
            15    8  12 1

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