 | | DRUG: Midazolam hydrochloride | |
| Entry |
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| Name |
Midazolam hydrochloride (USAN);
Versed (TN) |
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| Product |
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| Generic |
MIDAZOLAM (Akorn), MIDAZOLAM (Almaject), MIDAZOLAM (Almaject), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Civica), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Micro Labs Limited), MIDAZOLAM (SOMERSET THERAPEUTICS), MIDAZOLAM (SOMERSET THERAPEUTICS), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Steriscience Specialties Private Limited), MIDAZOLAM (Steriscience Specialties Private Limited), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (American Health Packaging), MIDAZOLAM HYDROCHLORIDE (Belcher Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Bryant Ranch Prepack), MIDAZOLAM HYDROCHLORIDE (Bryant Ranch Prepack), MIDAZOLAM HYDROCHLORIDE (Cardinal Health 107), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Henry Schein), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Hikma Pharmaceuticals USA), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Major Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Major Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Padagis US LLC), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM IN SODIUM CHLORIDE (Hikma Pharmaceuticals USA) |
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| Formula |
C18H13ClFN3. HCl
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| Exact mass |
361.0549
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| Mol weight |
362.2283
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG01567 GABA-A receptor agonist
DG03199 Antiepileptic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00920): | D00550<JP/US> D00696<US> |
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| Efficacy |
Anesthetic (intravenous), Sedative-hypnotic |
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| Comment |
Benzodiazepines
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CD Benzodiazepine derivatives
N05CD08 Midazolam
D00696 Midazolam hydrochloride (USAN) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG00920 Midazolam
D00696 Midazolam hydrochloride
DG01567 GABA-A receptor agonist
DG00920 Midazolam
D00696 Midazolam hydrochloride
DG03199 Antiepileptic agent
DG00920 Midazolam
D00696 Midazolam hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00920 Midazolam
D00696 Midazolam hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00696 Midazolam hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00696 Midazolam hydrochloride (USAN) <US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00696
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00696
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG00920 Midazolam
DG01567 GABA-A receptor agonist
DG00920 Midazolam
DG03199 Antiepileptic agent
DG00920 Midazolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00920 Midazolam
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 24
1 X Cl 37.0651 -16.6762
2 C2y C 32.2059 -17.5222
3 C8y C 31.3632 -16.4118
4 C8y C 31.6986 -15.0540
5 N4y N 32.9606 -14.4754
6 N2x N 33.6128 -17.4775
7 C8y C 34.2151 -15.0982
8 C1x C 34.5018 -16.4679
9 C8x C 30.6908 -14.0849
10 C8x C 29.3478 -14.4732
11 C8y C 29.0123 -15.8311
12 C8x C 30.0202 -16.7999
13 X Cl 27.6465 -16.2258
14 C8y C 31.5709 -18.7729
15 C8x C 30.1683 -18.7729
16 C8x C 29.4677 -19.9863
17 C8x C 30.1683 -21.1996
18 C8x C 31.5709 -21.1996
19 C8y C 32.2715 -19.9863
20 X F 33.6834 -19.9864
21 C8x C 35.1952 -14.0976
22 N5x N 34.5463 -12.8563
23 C8y C 33.1652 -13.0899
24 C1a C 32.1836 -12.1282
BOND 26
1 4 5 1
2 2 6 2
3 5 7 1
4 3 4 1
5 6 8 1
6 2 3 1
7 7 8 1
8 4 9 2
9 9 10 1
10 10 11 2
11 11 12 1
12 3 12 2
13 11 13 1
14 2 14 1
15 14 15 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 14 19 2
21 19 20 1
22 7 21 2
23 21 22 1
24 22 23 2
25 5 23 1
26 23 24 1
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