KEGG   DRUG: Desipramine hydrochloride
Entry
D00812                      Drug                                   
Name
Desipramine hydrochloride (JAN/USP);
Norpramin (TN)
Product
NORPRAMIN (Validus Pharmaceuticals LLC)
  Generic
DESIPRAMINE HCL (Direct_Rx), DESIPRAMINE HYDROCHLORIDE (Actavis Pharma), DESIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DESIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), DESIPRAMINE HYDROCHLORIDE (Chartwell RX), DESIPRAMINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Ingenus Pharmaceuticals)
Formula
C18H22N2. HCl
Exact mass
302.1550
Mol weight
302.84
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Remark
ATC code: N06AA01
Chemical structure group: DG00927
Product (DG00927): D00812<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Depression [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA01 Desipramine
      D00812  Desipramine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Desipramine
    D00812  Desipramine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00927  Desipramine
    D00812  Desipramine hydrochloride
  DG01728  Tricyclic antidepressant
   DG00927  Desipramine
    D00812  Desipramine hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   D00812  Desipramine hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00812  Desipramine hydrochloride (JAN/USP) <US>
    SLC6A4 (HTT)
     D00812  Desipramine hydrochloride (JAN/USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00812
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00927  Desipramine
  DG01728  Tricyclic antidepressant
   DG00927  Desipramine
Other DBs
CAS: 58-28-6
PubChem: 7847877
LigandBox: D00812
NIKKAJI: J231.274C
LinkDB
KCF data

ATOM        21
            1   C1x C    12.5108  -18.1831
            2   C8y C    11.6661  -17.0701
            3   C8y C    12.0023  -15.7092
            4   N1y N    13.2672  -15.1293
            5   C1x C    13.9209  -18.2084
            6   C8y C    14.5246  -15.7535
            7   C8y C    14.8120  -17.1264
            8   C8x C    10.9921  -14.7378
            9   C8x C     9.6460  -15.1271
            10  C8x C     9.3098  -16.4880
            11  C8x C    10.3200  -17.4591
            12  C8x C    16.1472  -17.5648
            13  C8x C    17.1946  -16.6276
            14  C8x C    16.9074  -15.2547
            15  C8x C    15.5719  -14.8162
            16  C1b C    13.2889  -13.7502
            17  C1b C    14.5167  -13.0670
            18  C1b C    15.6886  -13.7686
            19  N1b N    16.9145  -13.0865
            20  C1a C    18.1530  -13.8273
            21  X   Cl   20.1707  -16.3481
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1

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