KEGG   DRUG: Nortriptyline hydrochloride
Entry
D00816                      Drug                                   

Name
Nortriptyline hydrochloride (JP18/USP/INN);
Pamelor (TN)
Product
  Generic
NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCL (Direct_Rx), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (American Health Packaging), NORTRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), NORTRIPTYLINE HYDROCHLORIDE (AvPAK), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (Denton Pharma), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Pharmaceutical Associates), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (RedPharm Drug), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), NORTRIPTYLINE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C19H21N. HCl
Exact mass
299.1441
Mol weight
299.8377
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1179
ATC code: N06AA10
Chemical structure group: DG00935
Product (DG00935): D00816<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Depression [DS:H01646]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
map07048  Antimigraines
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA10 Nortriptyline
      D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Nortriptyline
    D00816  Nortriptyline hydrochloride (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00816  Nortriptyline hydrochloride (JP18/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
    SLC6A4 (HTT)
     D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00816  Nortriptyline hydrochloride
  D00816  Nortriptyline hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00816
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00816
Other DBs
CAS: 894-71-3
PubChem: 7847881
ChEBI: 7641
ChEMBL: CHEMBL1201156
DrugBank: DB00540
LigandBox: D00816
NIKKAJI: J358.588C
LinkDB
KCF data

ATOM        21
            1   C1x C    11.2452  -10.4773
            2   C8y C    10.4008   -9.3647
            3   C8y C    10.7369   -8.0042
            4   C2y C    12.0014   -7.4245
            5   C1x C    12.6548  -10.5026
            6   C8y C    13.2583   -8.0485
            7   C8y C    13.5456   -9.4210
            8   C8x C     9.7270   -7.0331
            9   C8x C     8.3814   -7.4223
            10  C8x C     8.0453   -8.7828
            11  C8x C     9.0551   -9.7536
            12  C8x C    14.8804   -9.8593
            13  C8x C    15.9275   -8.9223
            14  C8x C    15.6404   -7.5498
            15  C8x C    14.3053   -7.1115
            16  C2b C    11.9531   -6.0458
            17  C1b C    13.1804   -5.3628
            18  C1b C    14.3520   -6.0642
            19  N1b N    15.5775   -5.3823
            20  C1a C    16.8156   -6.1229
            21  X   Cl   18.9026   -8.6429
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1

» Japanese version   » Back

DBGET integrated database retrieval system