 | | DRUG: Nortriptyline hydrochloride | |
| Entry |
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| Name |
Nortriptyline hydrochloride (JP18/USP/INN);
Pamelor (TN) |
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| Product |
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| Generic |
NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCL (Direct_Rx), NORTRIPTYLINE HCL (Direct_rx), NORTRIPTYLINE HCL (Direct_rx), NORTRIPTYLINE HCL (Direct_rx), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (Advagen Pharma), NORTRIPTYLINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), NORTRIPTYLINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), NORTRIPTYLINE HYDROCHLORIDE (American Health Packaging), NORTRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), NORTRIPTYLINE HYDROCHLORIDE (AvPAK), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Cadila Healthcare Limited), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (Dr. Reddy's Laboratories), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PAI Holdings), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (RPK Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), NORTRIPTYLINE HYDROCHLORIDE (Teva Pharmaceuticals USA), NORTRIPTYLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C19H21N. HCl
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| Exact mass |
299.1441
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| Mol weight |
299.84
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00935): | D00816<JP/US> |
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Disease |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA10 Nortriptyline
D00816 Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Nortriptyline
D00816 Nortriptyline hydrochloride (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00816 Nortriptyline hydrochloride (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00935 Nortriptyline
D00816 Nortriptyline hydrochloride
DG01728 Tricyclic antidepressant
DG00935 Nortriptyline
D00816 Nortriptyline hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00935 Nortriptyline
D00816 Nortriptyline hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D00816 Nortriptyline hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00816 Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
SLC6A4 (HTT)
D00816 Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00816 Nortriptyline hydrochloride
D00816 Nortriptyline hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00816
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00816
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00935 Nortriptyline
DG01728 Tricyclic antidepressant
DG00935 Nortriptyline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00935 Nortriptyline
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 C1x C 11.2452 -10.4773
2 C8y C 10.4008 -9.3647
3 C8y C 10.7369 -8.0042
4 C2y C 12.0014 -7.4245
5 C1x C 12.6548 -10.5026
6 C8y C 13.2583 -8.0485
7 C8y C 13.5456 -9.4210
8 C8x C 9.7270 -7.0331
9 C8x C 8.3814 -7.4223
10 C8x C 8.0453 -8.7828
11 C8x C 9.0551 -9.7536
12 C8x C 14.8804 -9.8593
13 C8x C 15.9275 -8.9223
14 C8x C 15.6404 -7.5498
15 C8x C 14.3053 -7.1115
16 C2b C 11.9531 -6.0458
17 C1b C 13.1804 -5.3628
18 C1b C 14.3520 -6.0642
19 N1b N 15.5775 -5.3823
20 C1a C 16.8156 -6.1229
21 X Cl 18.9026 -8.6429
BOND 22
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
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