KEGG   DRUG: Trazodone hydrochloride
Entry
D00820                      Drug                                   
Name
Trazodone hydrochloride (JAN/USP);
Desyrel (TN)
Product
  Generic
TRAZODONE HCL (Advanced Rx Pharmacy of Tennessee), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (Accord Healthcare), TRAZODONE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), TRAZODONE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), TRAZODONE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), TRAZODONE HYDROCHLORIDE (American Health Packaging), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Apotex Corp), TRAZODONE HYDROCHLORIDE (Asclemed USA), TRAZODONE HYDROCHLORIDE (Aurolife Pharma LLC), TRAZODONE HYDROCHLORIDE (AvKARE), TRAZODONE HYDROCHLORIDE (AvKARE), TRAZODONE HYDROCHLORIDE (AvPAK), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Cardinal Health 107), TRAZODONE HYDROCHLORIDE (DIRECT RX), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Major Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Medsource Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Medsource Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Medsource Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NCS HealthCare of KY), TRAZODONE HYDROCHLORIDE (NCS HealthCare of KY), TRAZODONE HYDROCHLORIDE (Northwind Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Northwind Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Northwind Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Northwind Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmceuticals), TRAZODONE HYDROCHLORIDE (Oxford Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Pharmasource Meds), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (RPK Pharmaceuticals), TRAZODONE HYDROCHLORIDE (RPK Pharmaceuticals), TRAZODONE HYDROCHLORIDE (RPK Pharmaceuticals), TRAZODONE HYDROCHLORIDE (RPK Pharmaceuticals), TRAZODONE HYDROCHLORIDE (RPK Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Redpharm Drug), TRAZODONE HYDROCHLORIDE (Redpharm drug), TRAZODONE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAZODONE HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), TRAZODONE HYDROCHLORIDE (Zydus Lifesciences Limited), TRAZODONE HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C19H22ClN5O. HCl
Exact mass
407.1280
Mol weight
408.32
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N06AX05
Chemical structure group: DG00952
Product (DG00952): D00820<JP/US>
Efficacy
Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)
  Disease
Major depressive disorder [DS:H01646]
Comment
triazolopyridine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX05 Trazodone
      D00820  Trazodone hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Trazodone
    D00820  Trazodone hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00820  Trazodone hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
   DG00952  Trazodone
    D00820  Trazodone hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00952  Trazodone
    D00820  Trazodone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00952  Trazodone
     D00820  Trazodone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR2
     D00820  Trazodone hydrochloride (JAN/USP) <JP/US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D00820  Trazodone hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00820
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
   DG00952  Trazodone
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00952  Trazodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00952  Trazodone
Other DBs
CAS: 25332-39-2
PubChem: 7847885
ChEBI: 9655
LigandBox: D00820
NIKKAJI: J262.568G
LinkDB
KCF data

ATOM        27
            1   X   Cl   22.1900  -26.5300
            2   N4y N    11.9000  -24.0100
            3   C1b C    13.0900  -24.7100
            4   C1b C    14.2800  -24.0800
            5   C1b C    15.4700  -24.7800
            6   N1y N    16.7300  -24.0800
            7   C1x C    16.7300  -22.6800
            8   C1x C    17.9200  -24.7800
            9   C1x C    17.9200  -21.9100
            10  C1x C    19.1800  -24.0800
            11  N1y N    19.1800  -22.6800
            12  C8y C    20.3700  -21.9100
            13  C8x C    20.3700  -20.5100
            14  C8x C    21.5600  -22.6800
            15  C8y C    21.5600  -19.8100
            16  C8x C    22.8200  -21.9100
            17  C8x C    22.8200  -20.5100
            18  X   Cl   21.5600  -18.4100
            19  N5x N    11.4904  -22.6712
            20  C8y C    10.0906  -22.6471
            21  N4y N     9.6351  -23.9709
            22  C8y C    10.7533  -24.8132
            23  O5x O    10.8003  -26.1791
            24  C8x C     9.1720  -21.5906
            25  C8x C     7.7977  -21.8580
            26  C8x C     7.3422  -23.1818
            27  C8x C     8.2608  -24.2383
BOND        29
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     8  10 1
            9     9  11 1
            10   11  12 1
            11   12  13 1
            12   12  14 2
            13   13  15 2
            14   14  16 1
            15   15  17 1
            16   15  18 1
            17   10  11 1
            18   16  17 2
            19    2  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 1
            23    2  22 1
            24   22  23 2
            25   20  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   21  27 1

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KEGG   DRUG: Trazodone
Entry
D08626                      Drug                                   
Name
Trazodone (INN);
Trittico (TN)
Formula
C19H22ClN5O
Exact mass
371.1513
Mol weight
371.86
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07156
ATC code: N06AX05
Chemical structure group: DG00952
Product (DG00952): D00820<JP/US>
Efficacy
Tranquilizer, Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)
Comment
triazolopyridines
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX05 Trazodone
      D08626  Trazodone (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
   DG00952  Trazodone
    D08626  Trazodone
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00952  Trazodone
    D08626  Trazodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00952  Trazodone
     D08626  Trazodone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR2
     D08626  Trazodone (INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D08626  Trazodone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08626
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03056  Serotonin antagonist and reuptake inhibitor (SARI)
   DG00952  Trazodone
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00952  Trazodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00952  Trazodone
Other DBs
CAS: 19794-93-5
PubChem: 96025310
ChEBI: 9654
LigandBox: D08626
NIKKAJI: J10.767K
LinkDB
KCF data

ATOM        26
            1   N4y N    17.8500  -18.4800
            2   C1b C    19.0400  -19.1800
            3   C1b C    20.2300  -18.5500
            4   C1b C    21.4200  -19.2500
            5   N1y N    22.6800  -18.5500
            6   C1x C    22.6800  -17.1500
            7   C1x C    23.8700  -19.2500
            8   C1x C    23.8700  -16.3800
            9   C1x C    25.1300  -18.5500
            10  N1y N    25.1300  -17.1500
            11  C8y C    26.3200  -16.3800
            12  C8x C    26.3200  -14.9800
            13  C8x C    27.5100  -17.1500
            14  C8y C    27.5100  -14.2800
            15  C8x C    28.7700  -16.3800
            16  C8x C    28.7700  -14.9800
            17  X   Cl   27.5100  -12.8800
            18  N5x N    17.5000  -17.0800
            19  C8y C    16.1000  -17.0800
            20  N4y N    15.6100  -18.4100
            21  C8y C    16.7300  -19.2500
            22  O5x O    16.7300  -20.5800
            23  C8x C    15.1200  -16.0300
            24  C8x C    13.7900  -16.3100
            25  C8x C    13.3000  -17.6400
            26  C8x C    14.2800  -18.6900
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     5   7 1
            7     6   8 1
            8     7   9 1
            9     8  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2
            13   12  14 2
            14   13  15 1
            15   14  16 1
            16   14  17 1
            17    9  10 1
            18   15  16 2
            19    1  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 1
            23    1  21 1
            24   21  22 2
            25   19  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   20  26 1

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