 | | DRUG: Citalopram hydrobromide | |
| Entry |
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| Name |
Citalopram hydrobromide (USP);
Celexa (TN) |
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| Product |
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| Generic |
CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (A-S Medication Solutions), CITALOPRAM (Advanced Rx of Tennessee), CITALOPRAM (Amneal Pharmaceuticals LLC), CITALOPRAM (Aphena Pharma Solutions - Tennessee), CITALOPRAM (Aphena Pharma Solutions - Tennessee), CITALOPRAM (Aphena Pharma Solutions - Tennessee), CITALOPRAM (Aphena Pharma Solutions - Tennessee), CITALOPRAM (Aurobindo Pharma Limited), CITALOPRAM (Bryant Ranch Prepack), CITALOPRAM (Cardinal Health 107), CITALOPRAM (Chartwell RX), CITALOPRAM (Cipla USA), CITALOPRAM (Epic Pharma), CITALOPRAM (Golden State Medical Supply), CITALOPRAM (Hikma Pharmaceuticals USA), CITALOPRAM (Major Pharmaceuticals), CITALOPRAM (Mylan Pharmaceuticals), CITALOPRAM (NCS HealthCare of KY), CITALOPRAM (Northwind Pharmaceuticals), CITALOPRAM (Northwind Pharmaceuticals), CITALOPRAM (Northwind Pharmaceuticals), CITALOPRAM (Northwind Pharmaceuticals), CITALOPRAM (Northwind Pharmaceuticals), CITALOPRAM (NuCare Pharmaceuticals), CITALOPRAM (PD-Rx Pharmaceuticals), CITALOPRAM (PD-Rx Pharmaceuticals), CITALOPRAM (PD-Rx Pharmaceuticals), CITALOPRAM (PD-Rx Pharmaceuticals), CITALOPRAM (Proficient Rx LP), CITALOPRAM (Proficient Rx LP), CITALOPRAM (QPharma), CITALOPRAM (QUALLENT PHARMACEUTICALS HEALTH LLC), CITALOPRAM (REMEDYREPACK), CITALOPRAM (REMEDYREPACK), CITALOPRAM (REMEDYREPACK), CITALOPRAM (REMEDYREPACK), CITALOPRAM (REMEDYREPACK), CITALOPRAM (REMEDYREPACK), CITALOPRAM (Torrent Pharmaceuticals Limited), CITALOPRAM HYDROBROMIDE (A-S Medication Solutions), CITALOPRAM HYDROBROMIDE (A-S Medication Solutions), CITALOPRAM HYDROBROMIDE (A-S Medication Solutions), CITALOPRAM HYDROBROMIDE (ATLANTIC BIOLOGICALS CORP.), CITALOPRAM HYDROBROMIDE (Advanced Rx Pharmacy of Tennessee), CITALOPRAM HYDROBROMIDE (Aphena Pharma Solutions - Tennessee), CITALOPRAM HYDROBROMIDE (Aphena Pharma Solutions - Tennessee), CITALOPRAM HYDROBROMIDE (Aurobindo Pharma Limited), CITALOPRAM HYDROBROMIDE (Bryant Ranch Prepack), CITALOPRAM HYDROBROMIDE (Bryant Ranch Prepack), CITALOPRAM HYDROBROMIDE (Bryant Ranch Prepack), CITALOPRAM HYDROBROMIDE (Camber Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Denton Pharma), CITALOPRAM HYDROBROMIDE (Denton Pharma), CITALOPRAM HYDROBROMIDE (Exelan Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Glenmark Therapeutics), CITALOPRAM HYDROBROMIDE (Legacy Pharmaceutical Packaging), CITALOPRAM HYDROBROMIDE (Northwind Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Northwind Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (NuCare Pharmaceuticals), CITALOPRAM HYDROBROMIDE (PD-Rx Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Preferred Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Preferred Pharmaceuticals), CITALOPRAM HYDROBROMIDE (Proficient Rx LP), CITALOPRAM HYDROBROMIDE (Proficient Rx LP), CITALOPRAM HYDROBROMIDE (QPharma), CITALOPRAM HYDROBROMIDE (Quality Care Products), CITALOPRAM HYDROBROMIDE (Quality Care Products), CITALOPRAM HYDROBROMIDE (Quality Care Products), CITALOPRAM HYDROBROMIDE (REMEDYREPACK), CITALOPRAM HYDROBROMIDE (REMEDYREPACK), CITALOPRAM HYDROBROMIDE (St Marys Medical Park Pharmacy), CITALOPRAM HYDROBROMIDE (Sun Pharmaceutical Industries) |
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| Formula |
C20H21FN2O. HBr
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| Exact mass |
404.0900
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| Mol weight |
405.30
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
Transporter substrate
DG01665 ABCB1 substrate
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| Remark |
| Product (DG00943): | D00822<US> |
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| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
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| Disease |
Major depressive disorder [DS: H01646] |
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| Comment |
Citalopram derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
Transporter: ABCB1 [HSA: 5243]
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| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557]
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB04 Citalopram
D00822 Citalopram hydrobromide (USP) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Citalopram
D00822 Citalopram hydrobromide (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00943 Citalopram
D00822 Citalopram hydrobromide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00943 Citalopram
D00822 Citalopram hydrobromide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00943 Citalopram
D00822 Citalopram hydrobromide
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG00943 Citalopram
D00822 Citalopram hydrobromide
Transporter substrate
DG01665 ABCB1 substrate
DG00943 Citalopram
D00822 Citalopram hydrobromide
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
D00822 Citalopram hydrobromide
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D00822 Citalopram hydrobromide (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00822
Drug transporters
D00822
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00822
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00943 Citalopram
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00943 Citalopram
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00943 Citalopram
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG00943 Citalopram
Transporter substrate
DG01665 ABCB1 substrate
DG00943 Citalopram
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C1z C 25.2140 -17.1075
2 C8y C 23.8790 -16.6700
3 O2x O 26.0478 -15.9763
4 C8y C 23.8847 -15.2650
5 C8x C 22.6778 -17.3697
6 C1x C 25.2257 -14.8335
7 C8x C 22.6778 -14.5654
8 C8x C 21.4593 -16.6643
9 C8y C 21.4593 -15.2650
10 C3b C 20.2466 -14.5654
11 N3a N 19.0343 -13.8655
12 C8y C 25.2140 -18.5075
13 C8x C 24.0032 -19.2065
14 C8x C 24.0032 -20.6065
15 C8y C 25.2156 -21.3065
16 C8x C 26.4264 -20.6075
17 C8x C 26.4264 -19.2075
18 X F 25.2153 -22.6799
19 C1b C 26.6140 -17.1075
20 C1b C 27.2986 -18.2932
21 C1b C 28.6998 -18.2932
22 N1c N 29.3899 -19.4882
23 C1a C 30.7997 -19.4882
24 C1a C 28.7046 -20.6751
25 X Br 20.5107 -20.3997
BOND 26
1 1 2 1
2 1 3 1
3 2 4 2
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 2
8 7 9 2
9 9 10 1
10 4 6 1
11 8 9 1
12 10 11 3
13 1 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 15 16 1
18 16 17 2
19 12 17 1
20 15 18 1
21 1 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 22 24 1
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