KEGG   DRUG: Milnacipran hydrochloride
Entry
D01107                      Drug                                   
Name
Milnacipran hydrochloride (JAN/USAN);
Savella (TN);
Toledomin (TN)
Product
  Generic
Formula
C15H22N2O. HCl
Exact mass
282.1499
Mol weight
282.8089
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
Remark
Therapeutic category: 1179
ATC code: N06AX17
Chemical structure group: DG00960
Product (DG00960): D01107<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
Comment
selective serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX17 Milnacipran
      D01107  Milnacipran hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Fibromyalgia Agents
   Milnacipran
    D01107  Milnacipran hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01107  Milnacipran hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran
    D01107  Milnacipran hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D01107  Milnacipran hydrochloride (JAN/USAN) <JP/US>
    SLC6A4 (HTT)
     D01107  Milnacipran hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01107
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01107
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran
Other DBs
CAS: 101152-94-7
PubChem: 7848170
ChEBI: 31854
LigandBox: D01107
NIKKAJI: J399.913K J441.395D
LinkDB
KCF data

ATOM        19
            1   C8x C    19.8786  -14.8387
            2   C8x C    19.8786  -16.2385
            3   C8x C    21.0938  -16.9384
            4   C8y C    22.3018  -16.2385
            5   C8x C    22.3018  -14.8387
            6   C8x C    21.0938  -14.1388
            7   C5a C    23.7016  -16.2385
            8   C1x C    22.3159  -18.6704
            9   C1y C    23.7157  -18.6704
            10  C1z C    23.0089  -17.4543
            11  C1b C    24.4086  -19.8793
            12  O5a O    23.7645  -14.8387
            13  N1c N    25.1014  -16.2385
            14  C1b C    25.8013  -15.0262
            15  C1b C    25.8013  -17.4506
            16  C1a C    27.2011  -17.4474
            17  C1a C    27.2011  -15.0225
            18  N1a N    25.8084  -19.8837
            19  X   Cl   30.3116  -17.8220
BOND        19
            1     8  10 1
            2    10   9 1
            3     3   4 2
            4     9  11 1 #Up
            5    10   4 1 #Down
            6    10   7 1
            7     4   5 1
            8     7  12 2
            9     5   6 2
            10    7  13 1
            11    6   1 1
            12   13  14 1
            13   13  15 1
            14   15  16 1
            15    1   2 2
            16   14  17 1
            17    2   3 1
            18   11  18 1
            19    8   9 1

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KEGG   DRUG: Milnacipran
Entry
D08222                      Drug                                   
Name
Milnacipran (INN)
Formula
C15H22N2O
Exact mass
246.1732
Mol weight
246.348
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
Remark
ATC code: N06AX17
Chemical structure group: DG00960
Product (DG00960): D01107<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
Comment
selective serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX17 Milnacipran
      D08222  Milnacipran (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran
    D08222  Milnacipran
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08222  Milnacipran (INN)
    SLC6A4 (HTT)
     D08222  Milnacipran (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran
Other DBs
CAS: 92623-85-3
PubChem: 96024910
PDB-CCD: F0F[PDBj]
LigandBox: D08222
NIKKAJI: J304.816K
LinkDB
KCF data

ATOM        18
            1   C8x C    20.5100  -15.7500
            2   C8x C    20.5100  -17.1500
            3   C8x C    21.7000  -17.8500
            4   C8y C    22.9600  -17.1500
            5   C8x C    22.9600  -15.7500
            6   C8x C    21.7000  -15.0500
            7   C5a C    24.3600  -17.1500
            8   C1x C    22.9600  -19.6000
            9   C1y C    24.3600  -19.6000
            10  C1z C    23.6600  -18.3400
            11  C1b C    25.0600  -20.7900
            12  O5a O    24.3600  -15.7500
            13  N1c N    25.7600  -17.1500
            14  C1b C    26.4600  -15.9600
            15  C1b C    26.4600  -18.3400
            16  C1a C    27.8600  -18.3400
            17  C1a C    27.8600  -15.9600
            18  N1a N    26.4600  -20.7900
BOND        19
            1     8  10 1
            2    10   9 1
            3     3   4 2
            4     9  11 1 #Up
            5    10   4 1 #Down
            6    10   7 1
            7     4   5 1
            8     7  12 2
            9     5   6 2
            10    7  13 1
            11    6   1 1
            12   13  14 1
            13   13  15 1
            14   15  16 1
            15    1   2 2
            16   14  17 1
            17    2   3 1
            18   11  18 1
            19    8   9 1

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