| Entry |
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| Name |
Cilnidipine (JP18/INN);
Atelec (TN) |
|---|
| Formula |
C27H28N2O7
|
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| Exact mass |
492.1897
|
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| Mol weight |
492.52
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01572 Calcium channel N type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2149 |
| Product (mixture): | D10525<JP> |
|
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| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C19 [HSA: 1557]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA14 Cilnidipine
D01173 Cilnidipine (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01173 Cilnidipine (JP18/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D01173 Cilnidipine
DG01572 Calcium channel N type blocker
D01173 Cilnidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D01173 Cilnidipine
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D01173 Cilnidipine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01173 Cilnidipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D01173 Cilnidipine
DG03231 Antihypertensive
D01173 Cilnidipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1B
D01173 Cilnidipine (JP18/INN) <JP>
CACNA1-L
D01173 Cilnidipine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01173 Cilnidipine
D01173 Cilnidipine tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01173
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 C2y C 24.6047 -12.8785
2 C2y C 24.6047 -14.2686
3 C1y C 25.8115 -14.9635
4 C2y C 27.0112 -14.2686
5 C2y C 27.0112 -12.8785
6 N1x N 25.8115 -12.1834
7 C8y C 25.8132 -16.3537
8 C8x C 24.6163 -17.0454
9 C8x C 24.6181 -18.4355
10 C8x C 25.8229 -19.1291
11 C8y C 27.0259 -18.4325
12 C8x C 27.0242 -17.0424
13 N2b N 28.2307 -19.1260 #+
14 C7a C 28.2157 -14.9626
15 O6a O 28.2167 -16.3527
16 O7a O 29.4188 -14.2667
17 C1b C 30.6233 -14.9609
18 C2b C 31.8267 -14.2648
19 C2b C 33.2121 -14.2614
20 C1a C 28.2157 -12.1842
21 C1a C 23.4012 -12.1827
22 C7a C 23.4012 -14.9641
23 O7a O 22.1970 -14.2697
24 O6a O 23.4019 -16.3542
25 C1b C 20.9934 -14.9654
26 C1b C 19.7892 -14.2709
27 O2a O 18.5858 -14.9666
28 O3a O 29.7117 -18.1514
29 O3a O 28.2324 -20.5161 #-
30 C8y C 34.4127 -13.5593
31 C8x C 34.4749 -12.1687
32 C1a C 17.3815 -14.2723
33 C8x C 35.5926 -14.3129
34 C8x C 36.9051 -13.6678
35 C8x C 36.8974 -12.2772
36 C8x C 35.7174 -11.5236
BOND 38
1 3 4 1
2 17 18 1
3 4 5 2
4 18 19 2
5 5 6 1
6 5 20 1
7 7 8 2
8 1 21 1
9 8 9 1
10 2 22 1
11 9 10 2
12 22 23 1
13 10 11 1
14 22 24 2
15 11 12 2
16 23 25 1
17 12 7 1
18 25 26 1
19 6 1 1
20 26 27 1
21 11 13 1
22 13 28 2
23 13 29 1
24 4 14 1
25 19 30 1
26 3 7 1
27 14 15 2
28 1 2 2
29 14 16 1
30 2 3 1
31 31 30 1
32 16 17 1
33 27 32 1
34 30 33 2
35 33 34 1
36 34 35 2
37 35 36 1
38 31 36 2
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