KEGG   DRUG: Hydrocortisone succinateHelp
Entry
D01442                      Drug                                   

Name
Hydrocortisone succinate (JP17)
Formula
C25H34O8
Exact mass
462.2254
Mol weight
462.5327
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C12888
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<JP/US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP17)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01442  Hydrocortisone succinate (JP17)
  Hydrocortisone
   D01442  Hydrocortisone succinate (JP17)
  Hydrocortisone
   D01442  Hydrocortisone succinate (JP17)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D01442  Hydrocortisone succinate (JP17)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01442  Hydrocortisone succinate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01442  Hydrocortisone succinate
BRITE hierarchy
Other DBs
CAS: 2203-97-6
PubChem: 7848505
ChEBI: 31677
ChEMBL: CHEMBL1873165 CHEMBL343545 CHEMBL977
LigandBox: D01442
NIKKAJI: J7.358J
LinkDB All DBs
KCF data Show

ATOM        33
            1   C1y C    22.3789  -17.5209
            2   C1y C    21.1942  -18.2036
            3   C1z C    22.3789  -16.1552
            4   C1x C    24.7483  -17.5209
            5   C1y C    20.0095  -17.5209
            6   C1x C    21.1825  -19.5751
            7   C1z C    23.5695  -15.4666
            8   C1x C    21.1942  -15.4666
            9   C1a C    22.3731  -14.7837
            10  C1x C    24.7483  -16.1552
            11  C1z C    18.8191  -18.2036
            12  C1y C    20.0095  -16.1552
            13  C1x C    20.0095  -20.2578
            14  C5a C    23.5753  -14.1010
            15  O1a O    24.9118  -15.0931
            16  C2y C    18.8191  -19.5751
            17  C1x C    17.6401  -17.5209
            18  C1a C    18.8074  -16.8380
            19  O1a O    18.8191  -15.4666
            20  C1b C    24.7542  -13.4181
            21  O5a O    22.3848  -13.4181
            22  C2x C    17.6401  -20.2578
            23  C1x C    16.4497  -18.2036
            24  O7a O    25.9447  -14.1067
            25  C5x C    16.4497  -19.5751
            26  O5x O    15.2650  -20.2578
            27  C7a C    27.1454  -13.4076
            28  C1b C    28.3513  -14.0988
            29  C1b C    29.5571  -13.4007
            30  C6a C    30.7630  -14.0917
            31  O6a O    27.1407  -12.0114
            32  O6a O    30.7674  -15.4879
            33  O6a O    31.9699  -13.3897
BOND        36
            1     3   8 1
            2     3   9 1 #Up
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     6  13 1
            7     7  14 1 #Up
            8     7  15 1 #Down
            9    11  16 1
            10   11  17 1
            11   11  18 1 #Up
            12   12  19 1 #Up
            13   14  20 1
            14   14  21 2
            15   16  22 2
            16   17  23 1
            17   20  24 1
            18   22  25 1
            19   25  26 2
            20    7  10 1
            21    8  12 1
            22   13  16 1
            23   23  25 1
            24   24  27 1
            25    1   2 1
            26   27  28 1
            27    1   3 1
            28   28  29 1
            29    1   4 1
            30   29  30 1
            31    2   5 1
            32   27  31 2
            33    2   6 1
            34   30  32 2
            35    3   7 1
            36   30  33 1

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