KEGG   DRUG: ModafinilHelp
Entry
D01832                      Drug                                   

Name
Modafinil (JAN/USAN/INN);
Provigil (TN)
Product
  Generic
MODAFINIL (Actavis Pharma), MODAFINIL (Alembic Pharmaceuticals), MODAFINIL (Alembic Pharmaceuticals), MODAFINIL (Alembic Pharmaceuticals Limited), MODAFINIL (American Health Packaging), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Apotex Corp.), MODAFINIL (Aurobindo Pharma Limited), MODAFINIL (AvKARE), MODAFINIL (AvPAK), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (CIMA LABS), MODAFINIL (Cadila Healthcare Limited), MODAFINIL (Dispensing Solutions), MODAFINIL (Golden State Medical Supply), MODAFINIL (HERITAGE PHARMACEUTICALS), MODAFINIL (Hikma Pharmaceutical), MODAFINIL (Ingenus Pharmaceuticals), MODAFINIL (Lake Erie Medical DBA Quality Care Products LLC), MODAFINIL (Major Pharmaceuticals), MODAFINIL (Mylan Institutional), MODAFINIL (Mylan Pharmaceuticals), MODAFINIL (OrchidPharma), MODAFINIL (Par Pharmaceutical), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Rising Health), MODAFINIL (West-Ward Pharmaceuticals Corp), MODAFINIL (Zydus Pharmaceuticals (USA))
Formula
C15H15NO2S
Exact mass
273.0823
Mol weight
273.3501
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01971  Agents for narcolepsy
Enzyme substrate
 DG01633  CYP3A substrate
Enzyme inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
Enzyme inducer
 DG01637  CYP1A2 inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A inducer
  DG01635  CYP3A4 inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
Therapeutic category: 1179
ATC code: N06BA07
Product: D01832<JP/US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Comment
Treatment of narcolepsy and hypersomnia
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
CYP induction: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP3A4 [HSA:1576]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA07 Modafinil
      D01832  Modafinil (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Disorders, Other
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01832  Modafinil (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01832
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D01832
BRITE hierarchy
Other DBs
CAS: 68693-11-8
PubChem: 7848894
ChEBI: 31859
ChEMBL: CHEMBL1373
DrugBank: DB00745
LigandBox: D01832
NIKKAJI: J33.118J
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    21.4292  -18.4524
            2   C8x C    21.4292  -19.8539
            3   C8x C    22.6459  -20.5546
            4   C8x C    23.8554  -19.8539
            5   C8y C    23.8554  -18.4524
            6   C8x C    22.6459  -17.7516
            7   C1c C    25.0604  -17.7516
            8   C8y C    26.2708  -18.4524
            9   C8x C    26.2691  -19.8510
            10  C8x C    27.4794  -20.5517
            11  C8x C    28.6914  -19.8539
            12  C8x C    28.6931  -18.4552
            13  C8x C    27.4828  -17.7545
            14  S4a S    25.0590  -16.3501
            15  C1b C    26.2721  -15.6482
            16  O3c O    23.8447  -15.6505
            17  C5a C    26.2708  -14.2467
            18  N1a N    27.4839  -13.5447
            19  O5a O    25.0563  -13.5471
BOND        20
            1     4   5 1
            2     5   6 2
            3     6   1 1
            4     8   9 2
            5     9  10 1
            6    10  11 2
            7    11  12 1
            8    12  13 2
            9    13   8 1
            10    7  14 1
            11    5   7 1
            12   14  15 1
            13    1   2 2
            14   14  16 2
            15    7   8 1
            16   15  17 1
            17    2   3 1
            18   17  18 1
            19    3   4 2
            20   17  19 2

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