| Entry |
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| Name |
Vinorelbine tartrate (USP);
Vinorelbine ditartrate (JAN);
KW 2307;
Navelbine (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C45H54N4O8. (C4H6O6)2
|
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| Exact mass |
1078.4270
|
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| Mol weight |
1079.10
|
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| Structure |
|
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| Class |
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 4240 |
| Product (DG00692): | D01935<JP/US> |
|
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| Efficacy |
Antineoplastic, Tubulin polymerization inhibitor |
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| Disease |
Non-small cell lung cancer [DS: H00014] |
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| Comment |
Semisynthetic vinblastine derivative
|
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| Target |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CA Vinca alkaloids and analogues
L01CA04 Vinorelbine
D01935 Vinorelbine tartrate (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D01935 Vinorelbine tartrate (USP); Vinorelbine ditartrate (JAN)
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00692 Vinorelbine
D01935 Vinorelbine tartrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00692 Vinorelbine
D01935 Vinorelbine tartrate
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D01935 Vinorelbine tartrate (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01935
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00692 Vinorelbine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00692 Vinorelbine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 77
1 O6a O 24.3546 -13.2518
2 C6a C 25.5651 -12.5510
3 C1c C 26.7756 -13.2518
4 C1c C 27.9860 -12.5510
5 C6a C 29.1965 -13.2518
6 O6a O 30.4070 -12.5510
7 O6a O 25.5651 -11.1494
8 O1a O 26.7756 -14.6534
9 O1a O 27.9860 -11.1494
10 O6a O 29.1965 -14.6534
11 C1z C 10.5700 -14.7000
12 C8y C 9.4500 -13.9300
13 C1x C 11.8300 -13.9300
14 C7a C 10.2200 -15.9600
15 C8y C 9.4500 -12.5300
16 N4x N 8.3300 -14.5600
17 C1y C 11.8300 -12.6700
18 O7a O 8.7500 -16.4500
19 O6a O 11.0600 -17.0100
20 C8y C 7.1400 -12.5300
21 C8y C 7.1400 -13.9300
22 C1x C 10.7100 -12.0400
23 C1a C 7.9100 -17.8500
24 C8x C 5.9500 -11.9000
25 C8x C 5.9500 -14.5600
26 N1y N 10.7100 -10.7800
27 C8x C 4.9000 -12.5300
28 C8x C 4.9000 -13.9300
29 C1x C 11.8300 -10.0100
30 C2y C 12.9500 -10.6400
31 C2x C 12.9500 -11.8300
32 C1b C 14.2100 -9.9400
33 C1a C 15.4000 -10.6400
34 C1x C 9.4500 -11.1300
35 C1z C 18.1300 -16.8700
36 C1y C 19.2500 -16.1700
37 C1y C 18.1300 -18.1300
38 C1x C 17.2900 -15.7500
39 C1z C 20.3700 -16.8700
40 N1y N 19.2500 -14.8400
41 C1z C 19.2500 -18.8300
42 N1y N 17.0100 -18.8300
43 C8y C 15.8900 -18.1300
44 C1x C 17.9200 -14.8400
45 C1y C 20.3700 -18.1300
46 C2x C 21.5600 -16.1700
47 C1b C 21.4900 -17.5000
48 C1x C 20.3700 -14.2100
49 C7a C 20.1600 -19.9500
50 O1a O 18.7600 -20.7200
51 C1a C 17.0100 -20.1600
52 O7a O 23.7300 -19.4600
53 C2x C 21.5600 -14.8400
54 C1a C 22.6100 -16.8700
55 O7a O 20.1600 -21.2800
56 O6a O 21.4900 -19.4600
57 C1a C 21.3500 -21.9800
58 C1a C 26.1800 -19.4600
59 C7a C 24.9200 -18.7600
60 O6a O 24.9200 -17.3600
61 C8y C 15.8900 -16.8700
62 C8x C 14.7700 -16.2400
63 C8x C 14.7700 -18.8300
64 C8y C 13.6500 -16.8700
65 C8y C 13.6500 -18.2000
66 O2a O 12.5300 -18.8300
67 C1a C 11.4100 -18.2000
68 O6a O 24.3546 -13.2518
69 C6a C 25.5651 -12.5510
70 C1c C 26.7756 -13.2518
71 C1c C 27.9860 -12.5510
72 C6a C 29.1965 -13.2518
73 O6a O 30.4070 -12.5510
74 O6a O 29.1965 -14.6534
75 O1a O 27.9860 -11.1494
76 O1a O 26.7756 -14.6534
77 O6a O 25.5651 -11.1494
BOND 83
1 11 12 1
2 11 13 1
3 11 14 1 #Up
4 12 15 2
5 12 16 1
6 13 17 1
7 14 18 1
8 14 19 2
9 15 20 1
10 16 21 1
11 17 22 1
12 17 31 1
13 18 23 1
14 20 24 1
15 21 25 1
16 26 22 1
17 24 27 2
18 25 28 2
19 26 29 1
20 20 21 2
21 30 29 1
22 27 28 1
23 30 31 2
24 30 32 1
25 32 33 1
26 15 34 1
27 26 34 1 #Up
28 35 36 1
29 35 37 1
30 35 38 1 #Up
31 36 39 1
32 36 40 1
33 37 41 1
34 37 42 1
35 38 44 1
36 39 45 1
37 39 46 1
38 39 47 1 #Down
39 40 48 1
40 41 49 1 #Down
41 41 50 1 #Up
42 42 51 1
43 45 52 1 #Up
44 46 53 2
45 47 54 1
46 49 55 1
47 40 44 1
48 41 45 1
49 42 43 1
50 48 53 1
51 49 56 2
52 55 57 1
53 58 59 1
54 52 59 1
55 59 60 2
56 61 62 1
57 43 63 1
58 62 64 2
59 63 65 2
60 65 66 1
61 66 67 1
62 64 65 1
63 61 35 1
64 61 43 2
65 11 64 1 #Down
66 1 2 1
67 2 3 1
68 3 4 1
69 4 5 1
70 5 6 1
71 2 7 2
72 3 8 1 #Up
73 4 9 1 #Up
74 5 10 2
75 68 69 1
76 69 70 1
77 70 71 1
78 71 72 1
79 72 73 1
80 69 77 2
81 70 76 1 #Up
82 71 75 1 #Up
83 72 74 2
BRACKET 1 23.0300 -15.4000 23.0300 -10.2200
1 31.8500 -10.2200 31.8500 -15.4000
1 2
ORIGINAL 1 1 2 3 4 5 6 10 9 8 7
REPEAT 1 71 72 73 74 75 76 77 78 79 80
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