KEGG   DRUG: Vinorelbine tartrateHelp
Entry
D01935                      Drug                                   

Name
Vinorelbine tartrate (USP);
Vinorelbine ditartrate (JAN);
KW 2307;
Navelbine (TN)
Product
  Generic
Formula
C45H54N4O8. (C4H6O6)2
Exact mass
1078.427
Mol weight
1079.1059
Structure
Mol fileKCF fileDB search
Class
Antineoplastic
 DG01965  Antineoplastic, vinca alkaloid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4240
ATC code: L01CA04
Chemical structure group: DG00692
Product (DG00692): D01935<JP/US>
Efficacy
Antineoplastic, Tubulin polymerization inhibitor
  Disease
Non-small cell lung cancer [DS:H00014]
Comment
Semisynthetic vinblastine derivative
Target
  Pathway
hsa04540  Gap junction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CA Vinca alkaloids and analogues
     L01CA04 Vinorelbine
      D01935  Vinorelbine tartrate (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   424  Plant extract preparations
    4240  Plant extract preparations
     D01935  Vinorelbine tartrate (USP); Vinorelbine ditartrate (JAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D01935  Vinorelbine tartrate (USP) <JP/US>
Antineoplastics [br08340.html]
 D01935
BRITE hierarchy
Other DBs
CAS: 125317-39-7
PubChem: 7848997
ChEBI: 32296
DrugBank: DB00361
LigandBox: D01935
NIKKAJI: J533.816F
LinkDB All DBs
KCF data Show

ATOM        77
            1   O6a O    21.2046  -10.0318
            2   C6a C    22.4151   -9.3310
            3   C1c C    23.6256  -10.0318
            4   C1c C    24.8360   -9.3310
            5   C6a C    26.0465  -10.0318
            6   O6a O    27.2570   -9.3310
            7   O6a O    22.4151   -7.9294
            8   O1a O    23.6256  -11.4334
            9   O1a O    24.8360   -7.9294
            10  O6a O    26.0465  -11.4334
            11  C1z C     7.4200  -11.4800
            12  C8y C     6.3000  -10.7100
            13  C1x C     8.6800  -10.7100
            14  C7a C     7.0700  -12.7400
            15  C8y C     6.3000   -9.3100
            16  N4x N     5.1800  -11.3400
            17  C1y C     8.6800   -9.4500
            18  O7a O     5.6000  -13.2300
            19  O6a O     7.9100  -13.7900
            20  C8y C     3.9900   -9.3100
            21  C8y C     3.9900  -10.7100
            22  C1x C     7.5600   -8.8200
            23  C1a C     4.7600  -14.6300
            24  C8x C     2.8000   -8.6800
            25  C8x C     2.8000  -11.3400
            26  N1y N     7.5600   -7.5600
            27  C8x C     1.7500   -9.3100
            28  C8x C     1.7500  -10.7100
            29  C1x C     8.6800   -6.7900
            30  C2y C     9.8000   -7.4200
            31  C2x C     9.8000   -8.6100
            32  C1b C    11.0600   -6.7200
            33  C1a C    12.2500   -7.4200
            34  C1x C     6.3000   -7.9100
            35  C1z C    14.9800  -13.6500
            36  C1y C    16.1000  -12.9500
            37  C1y C    14.9800  -14.9100
            38  C1x C    14.1400  -12.5300
            39  C1z C    17.2200  -13.6500
            40  N1y N    16.1000  -11.6200
            41  C1z C    16.1000  -15.6100
            42  N1y N    13.8600  -15.6100
            43  C8y C    12.7400  -14.9100
            44  C1x C    14.7700  -11.6200
            45  C1y C    17.2200  -14.9100
            46  C2x C    18.4100  -12.9500
            47  C1b C    18.3400  -14.2800
            48  C1x C    17.2200  -10.9900
            49  C7a C    17.0100  -16.7300
            50  O1a O    15.6100  -17.5000
            51  C1a C    13.8600  -16.9400
            52  O7a O    20.5800  -16.2400
            53  C2x C    18.4100  -11.6200
            54  C1a C    19.4600  -13.6500
            55  O7a O    17.0100  -18.0600
            56  O6a O    18.3400  -16.2400
            57  C1a C    18.2000  -18.7600
            58  C1a C    23.0300  -16.2400
            59  C7a C    21.7700  -15.5400
            60  O6a O    21.7700  -14.1400
            61  C8y C    12.7400  -13.6500
            62  C8x C    11.6200  -13.0200
            63  C8x C    11.6200  -15.6100
            64  C8y C    10.5000  -13.6500
            65  C8y C    10.5000  -14.9800
            66  O2a O     9.3800  -15.6100
            67  C1a C     8.2600  -14.9800
            68  O6a O    21.2046  -10.0318
            69  C6a C    22.4151   -9.3310
            70  C1c C    23.6256  -10.0318
            71  C1c C    24.8360   -9.3310
            72  C6a C    26.0465  -10.0318
            73  O6a O    27.2570   -9.3310
            74  O6a O    26.0465  -11.4334
            75  O1a O    24.8360   -7.9294
            76  O1a O    23.6256  -11.4334
            77  O6a O    22.4151   -7.9294
BOND        83
            1    11  12 1
            2    11  13 1
            3    11  14 1 #Up
            4    12  15 2
            5    12  16 1
            6    13  17 1
            7    14  18 1
            8    14  19 2
            9    15  20 1
            10   16  21 1
            11   17  22 1
            12   17  31 1
            13   18  23 1
            14   20  24 1
            15   21  25 1
            16   26  22 1
            17   24  27 2
            18   25  28 2
            19   26  29 1
            20   20  21 2
            21   30  29 1
            22   27  28 1
            23   30  31 2
            24   30  32 1
            25   32  33 1
            26   15  34 1
            27   26  34 1 #Up
            28   35  36 1
            29   35  37 1
            30   35  38 1 #Up
            31   36  39 1
            32   36  40 1
            33   37  41 1
            34   37  42 1
            35   38  44 1
            36   39  45 1
            37   39  46 1
            38   39  47 1 #Down
            39   40  48 1
            40   41  49 1 #Down
            41   41  50 1 #Up
            42   42  51 1
            43   45  52 1 #Up
            44   46  53 2
            45   47  54 1
            46   49  55 1
            47   40  44 1
            48   41  45 1
            49   42  43 1
            50   48  53 1
            51   49  56 2
            52   55  57 1
            53   58  59 1
            54   52  59 1
            55   59  60 2
            56   61  62 1
            57   43  63 1
            58   62  64 2
            59   63  65 2
            60   65  66 1
            61   66  67 1
            62   64  65 1
            63   61  35 1
            64   61  43 2
            65   11  64 1 #Down
            66    1   2 1
            67    2   3 1
            68    3   4 1
            69    4   5 1
            70    5   6 1
            71    2   7 2
            72    3   8 1 #Up
            73    4   9 1 #Up
            74    5  10 2
            75   68  69 1
            76   69  70 1
            77   70  71 1
            78   71  72 1
            79   72  73 1
            80   69  77 2
            81   70  76 1 #Up
            82   71  75 1 #Up
            83   72  74 2
BRACKET     1    19.8800  -12.1800   19.8800   -7.0000
            1    28.7000   -7.0000   28.7000  -12.1800
            1  2
 ORIGINAL  1    1   2   3   4   5   6  10   9   8   7
 REPEAT    1   70  71  72  73  74  75  76  77  78  79

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