| Entry |
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| Symbol |
TUBB4A, DYT4, TUBB4, beta-5
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| Name |
(RefSeq) tubulin beta 4A class IVa
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
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| Element |
| N00976 | Retrograde axonal transport |
| N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
| N00978 | Anterograde axonal transport |
| N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
| N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
| N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
| N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
| N01285 | Microtubule-RHOA signaling pathway |
| N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
| N01295 | Rab7-regulated microtubule minus-end directed transport |
| N01297 | Arl8-regulated microtubule plus-end directed transport |
| N01298 | Salmonella SifA to microtubule plus-end directed transport |
| N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
| N01403 | Zn to anterograde axonal transport |
| N01414 | Iron to anterograde axonal transport |
| N01535 | Kinetochore microtubule attachment |
| N01547 | Kinetochore fiber organization |
| N01549 | Branching microtubule nucleation |
| N01553 | Promotion of microtubule growth |
| N01561 | Microtubule depolymerization |
| N01562 | Microtubule depolymerization at the minus ends |
| N01832 | NTN1-MAP1B axon guidance signaling |
| N01833 | DRAXIN-MAP1B axon guidance signaling |
| N01834 | SEMA3A-MAP1B axon guidance signaling |
| N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
| N01836 | Microtubule plus end regulation network |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
| N01838 | Regulation of synaptic plasticity, p140Cap |
| N01839 | Severing of microtubule, SPAST/KATN |
| N01840 | Severing of microtubule, KIF2A |
| N01841 | Anterograde axonal transport, Kinesin-2 |
| N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
| N01843 | Anterograde dendrite transport, Kinesin-4 |
| N01844 | Anterograde dendrite transport, Kinesin-6 |
| N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
| N01846 | Retrograde axonal/dendrite transport, Dynein |
| N01857 | SEMA3A-DCX axon guidance signaling |
| N01858 | EFNB1-MAPT axon guidance signaling |
| N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
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| Disease |
| H00679 | Hypomyelinating leukodystrophy |
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| Drug target |
| Belantamab mafodotin: | D11595<JP> |
| Brentuximab vedotin: | D09587<JP/US> |
| Denintuzumab mafodotin: | D11232 |
| Enfortumab vedotin: | D11525<JP/US> |
| Farletuzumab ecteribulin: | D12183 |
| Lorvotuzumab mertansine: | D09927 |
| Mirvetuximab soravtansine: | D10954<US> |
| Tasidotin hydrochloride: | D06009 |
| Tisotumab vedotin: | D11814<JP/US> |
| Trastuzumab emtansine: | D09980<JP/US> |
| Tusamitamab ravtansine: | D12310 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
10382 (TUBB4A)
09144 Cellular community - eukaryotes
04540 Gap junction
10382 (TUBB4A)
09142 Cell motility
04814 Motor proteins
10382 (TUBB4A)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
10382 (TUBB4A)
05132 Salmonella infection
10382 (TUBB4A)
09164 Neurodegenerative disease
05010 Alzheimer disease
10382 (TUBB4A)
05012 Parkinson disease
10382 (TUBB4A)
05014 Amyotrophic lateral sclerosis
10382 (TUBB4A)
05016 Huntington disease
10382 (TUBB4A)
05020 Prion disease
10382 (TUBB4A)
05022 Pathways of neurodegeneration - multiple diseases
10382 (TUBB4A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
10382 (TUBB4A)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
10382 (TUBB4A)
04147 Exosome [BR:hsa04147]
10382 (TUBB4A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
10382 (TUBB4A)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
10382 (TUBB4A)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
10382 (TUBB4A)
Exosomal proteins of colorectal cancer cells
10382 (TUBB4A)
Exosomal proteins of bladder cancer cells
10382 (TUBB4A)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
19:complement(6494319..6502848)
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| AA seq |
444 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA |
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| NT seq |
1335 nt +upstreamnt +downstreamnt
atgcgggagatcgtgcacctgcaggccggccagtgcggcaaccagatcggggccaagttt
tgggaggttatcagtgacgaacatggcatcgaccccacaggcacataccatggggacagt
gacctgcaactggagaggatcaacgtgtactacaacgaggccacaggaggaaattatgtc
cccagagcggtgctggtggacctggaacccggcaccatggactctgtccgttctggcccc
ttcggtcagatctttcggccggacaacttcgtgtttggccaatccggagccggcaacaac
tgggcaaaggggcactacacggagggcgcagagctggtggacgctgtcctggacgtagtc
cggaaggaggccgagagctgcgactgccttcagggcttccagctgacccactcgctgggg
ggtggcacggggtccggaatgggcacgctgctcatcagtaagatccgcgaggagttccca
gaccgcatcatgaacaccttcagcgtggtgccctcgcccaaagtgtcagacacggtggtg
gagccctacaacgccacgctgtctgtgcaccagctggtggagaatacggatgagacctac
tgcatcgacaacgaggcactctacgacatctgtttccgcaccctcaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgccgacctgcgcaagctggccgtcaacatggttcccttt
cctcgcctgcacttcttcatgcccggcttcgcacccctgaccagccggggcagccagcag
taccgggccctgacggtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gcggcgtgcgacccgcgccacggccgctacctgaccgtggccgccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctgagcgtgcagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatggccgcgaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcttgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtatct
gagtaccagcagtaccaggacgccacggccgaggagggcgagttcgaggaggaggcggag
gaggaggtggcctag |
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