Homo sapiens (human): 10382
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Entry
10382 CDS
T01001
Gene name
TUBB4A, DYT4, TUBB4, beta-5
Definition
(RefSeq) tubulin beta 4A class IVa
KO
K07375
tubulin beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa04145
Phagosome
hsa04540
Gap junction
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
Network
nt06125
Membrane trafficking (bacteria)
nt06135
Cytoskeletal regulation (viruses and bacteria)
nt06419
Microtubule-based transport
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
Element
N00976
Retrograde axonal transport
N00977
Mutation-caused aberrant Htt to retrograde axonal transport
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01158
Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285
Microtubule-RHOA signaling pathway
N01286
Escherichia EspG to Microtubule-RHOA signaling pathway
N01295
Rab7-regulated microtubule minus-end directed transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
Disease
H00679
Hypomyelinating leukodystrophy
Drug target
Avanbulin:
D11681
Batabulin (
DG01412
):
D03059
D06560
Belantamab mafodotin:
D11595
<US>
Brentuximab vedotin:
D09587
<JP/US>
Cabazitaxel (
DG00695
):
D09755
D10452
<JP/US>
Cevipabulin (
DG01413
):
D06576
D08889
Colchicine:
D00570
<JP/US>
Denintuzumab mafodotin:
D11232
Docetaxel (
DG00694
):
D02165
<JP/US>
D07866
<JP/US>
Enfortumab vedotin:
D11525
<US>
Eribulin:
D08914
<JP/US>
Estramustine (
DG00724
):
D02398
D04066
D06397
<JP/US>
Glembatumumab vedotin:
D09912
Indibulin:
D10013
Ixabepilone:
D04645
Lexibulin:
D10073
Lifastuzumab vedotin:
D11238
Lisavanbulin:
D11494
Maytansine:
D04864
Mivobulin isethionate:
D05062
Paclitaxel:
D00491
<JP/US>
Paclitaxel poliglumex:
D05333
Soblidotin:
D01919
Taltobulin:
D06001
Tasidotin hydrochloride:
D06009
Tirbanibulin (
DG03082
):
D11691
<US>
D11692
Trastuzumab emtansine:
D09980
<JP/US>
Verubulin (
DG01411
):
D10029
D10030
Vinblastine (
DG00689
):
D01068
<JP/US>
D08675
Vincristine (
DG00690
):
D02197
<JP/US>
D08679
Vindesine (
DG00691
):
D01769
<JP>
D06304
Vinepidine sulfate:
D06305
Vinflunine:
D09032
Vinglycinate sulfate:
D06306
Vinleurosine sulfate:
D06307
Vinorelbine (
DG00692
):
D01935
<JP/US>
D08680
Vinrosidine sulfate:
D06308
Vinzolidine sulfate:
D06309
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
10382 (TUBB4A)
09144 Cellular community - eukaryotes
04540 Gap junction
10382 (TUBB4A)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
10382 (TUBB4A)
05132 Salmonella infection
10382 (TUBB4A)
09164 Neurodegenerative disease
05010 Alzheimer disease
10382 (TUBB4A)
05012 Parkinson disease
10382 (TUBB4A)
05014 Amyotrophic lateral sclerosis
10382 (TUBB4A)
05016 Huntington disease
10382 (TUBB4A)
05020 Prion disease
10382 (TUBB4A)
05022 Pathways of neurodegeneration - multiple diseases
10382 (TUBB4A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
10382 (TUBB4A)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
10382 (TUBB4A)
04147 Exosome [BR:
hsa04147
]
10382 (TUBB4A)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation and ciliogenesis proteins
Microtubules and associated factors
Other tubulins
10382 (TUBB4A)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
10382 (TUBB4A)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
10382 (TUBB4A)
Exosomal proteins of colorectal cancer cells
10382 (TUBB4A)
Exosomal proteins of bladder cancer cells
10382 (TUBB4A)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Tubulin
Tubulin_C
Misat_Tub_SegII
Tubulin_3
Tubulin_2
Motif
Other DBs
NCBI-GeneID:
10382
NCBI-ProteinID:
NP_001276058
OMIM:
602662
HGNC:
20774
Ensembl:
ENSG00000104833
Vega:
OTTHUMG00000181829
Pharos:
P04350
(Tclin)
UniProt:
P04350
LinkDB
All DBs
Position
19p13.3
AA seq
444 aa
AA seq
DB search
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA
NT seq
1335 nt
NT seq
+upstream
nt +downstream
nt
atgcgggagatcgtgcacctgcaggccggccagtgcggcaaccagatcggggccaagttt
tgggaggttatcagtgacgaacatggcatcgaccccacaggcacataccatggggacagt
gacctgcaactggagaggatcaacgtgtactacaacgaggccacaggaggaaattatgtc
cccagagcggtgctggtggacctggaacccggcaccatggactctgtccgttctggcccc
ttcggtcagatctttcggccggacaacttcgtgtttggccaatccggagccggcaacaac
tgggcaaaggggcactacacggagggcgcagagctggtggacgctgtcctggacgtagtc
cggaaggaggccgagagctgcgactgccttcagggcttccagctgacccactcgctgggg
ggtggcacggggtccggaatgggcacgctgctcatcagtaagatccgcgaggagttccca
gaccgcatcatgaacaccttcagcgtggtgccctcgcccaaagtgtcagacacggtggtg
gagccctacaacgccacgctgtctgtgcaccagctggtggagaatacggatgagacctac
tgcatcgacaacgaggcactctacgacatctgtttccgcaccctcaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgccgacctgcgcaagctggccgtcaacatggttcccttt
cctcgcctgcacttcttcatgcccggcttcgcacccctgaccagccggggcagccagcag
taccgggccctgacggtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gcggcgtgcgacccgcgccacggccgctacctgaccgtggccgccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctgagcgtgcagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatggccgcgaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcttgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtatct
gagtaccagcagtaccaggacgccacggccgaggagggcgagttcgaggaggaggcggag
gaggaggtggcctag
DBGET
integrated database retrieval system
