KEGG T01001: 81027

Homo sapiens (human): 81027

Entry

81027 CDS T01001

Symbol

TUBB1

Name

(RefSeq) tubulin beta 1 class VI

K07375

tubulin beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04540

Gap junction

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

Network

nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease

Element

N00976

Retrograde axonal transport

N00977

Mutation-caused aberrant Htt to retrograde axonal transport

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01018

Mutation-caused aberrant Abeta to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01158

Mutation-caused aberrant DCTN1 to retrograde axonal transport

N01285

Microtubule-RHOA signaling pathway

N01286

Escherichia EspG to Microtubule-RHOA signaling pathway

N01295

Rab7-regulated microtubule minus-end directed transport

N01297

Arl8-regulated microtubule plus-end directed transport

N01298

Salmonella SifA to microtubule plus-end directed transport

N01299

Salmonella PipB2 to microtubule plus-end directed transport

N01403

Zn to anterograde axonal transport

N01414

Iron to anterograde axonal transport

Disease

H01740

Macrothrombocytopenia

Drug target

Avanbulin:

D11681

Batabulin (DG01412):

D03059 D06560

Belantamab mafodotin:

D11595<US>

Brentuximab vedotin:

D09587<JP/US>

Cabazitaxel (DG00695):

D09755 D10452<JP/US>

Cevipabulin (DG01413):

D06576 D08889

Colchicine:

D00570<JP/US>

Denintuzumab mafodotin:

D11232

Docetaxel (DG00694):

D02165<JP/US> D07866<JP/US>

Enfortumab vedotin:

D11525<JP/US>

Eribulin:

D08914<JP/US>

Estramustine (DG00724):

D02398 D04066 D06397<JP/US>

Farletuzumab ecteribulin:

D12183

Glembatumumab vedotin:

D09912

Indibulin:

D10013

Ixabepilone:

D04645<US>

Lexibulin:

D10073

Lifastuzumab vedotin:

Lisavanbulin:

Maytansine:

Mecbotamab vedotin:

Mivobulin isethionate:

D05062

Ozuriftmab vedotin:

D12210

Paclitaxel:

D00491<JP/US>

Paclitaxel poliglumex:

D05333

Soblidotin:

D01919

Taltobulin:

D06001

Tasidotin hydrochloride:

D06009

Tirbanibulin (DG03082):

D11691<US> D11692

Tisotumab vedotin:

D11814<US>

Trastuzumab emtansine:

D09980<JP/US>

Vedotin:

D09691

Verubulin (DG01411):

D10029 D10030

Vinblastine (DG00689):

D01068<JP/US> D08675

Vincristine (DG00690):

D02197<JP/US> D08679

Vindesine (DG00691):

D01769<JP> D06304

Vinepidine sulfate:

D06305

Vinflunine:

D09032

Vinglycinate sulfate:

D06306

Vinleurosine sulfate:

D06307

Vinorelbine (DG00692):

D01935<JP/US> D08680

Vinrosidine sulfate:

D06308

Vinzolidine sulfate:

D06309

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    81027 (TUBB1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    81027 (TUBB1)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    81027 (TUBB1)
   05132 Salmonella infection
    81027 (TUBB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    81027 (TUBB1)
   05012 Parkinson disease
    81027 (TUBB1)
   05014 Amyotrophic lateral sclerosis
    81027 (TUBB1)
   05016 Huntington disease
    81027 (TUBB1)
   05020 Prion disease
    81027 (TUBB1)
   05022 Pathways of neurodegeneration - multiple diseases
    81027 (TUBB1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    81027 (TUBB1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    81027 (TUBB1)
   04147 Exosome [BR:hsa04147]
    81027 (TUBB1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     81027 (TUBB1)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    81027 (TUBB1)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   81027 (TUBB1)
  Exosomal proteins of colorectal cancer cells
   81027 (TUBB1)
  Exosomal proteins of bladder cancer cells
   81027 (TUBB1)

SSDB

Motif

Pfam:

Tubulin Tubulin_C Misat_Tub_SegII Tubulin_2 Tubulin_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9H4B7(Tclin)

UniProt:

Q9H4B7

LinkDB

Position

20:59016026..59026654

AA seq 451 aa
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

NT seq 1356 nt +upstreamnt +downstreamnt
atgcgtgaaattgtccatattcagattggccagtgtggcaaccagatcggagccaagttc
tgggagatgattggtgaggaacacgggatcgacttggctgggagcgaccgcggggcctcg
gccttgcagctggagagaatcagcgtgtactacaacgaagcctacggtaggaaatatgtg
ccccgagcagtcttggtggacctagaacctgggacgatggacagcattcgatctagcaaa
ttaggagctctctttcaacccgacagttttgtccatggtaactctggggctggcaacaac
tgggccaaaggccactacacggagggagccgagctgatcgagaatgtcctagaggtggtg
aggcacgagagtgagagctgtgactgcctgcagggcttccagatcgtccactccctgggc
gggggcacaggctccgggatgggcactctgctcatgaacaagattagagaggagtacccg
gaccggatcatgaattccttcagcgtcatgccttctcccaaggtgtcggacactgtggtg
gagccctacaacgcggttctgtctatccaccagctgattgagaatgcagatgcctgtttc
tgcattgacaatgaggccctctatgacatctgcttccgtaccctgaagctgacgacaccc
acctatggggatctcaaccacctagtgtccttgaccatgagcggcataaccacctccctc
cggttcccgggtcagctcaacgcagacctgcgcaagctggcggtgaacatggtccccttc
ccccgcctgcacttctttatgcccggctttgccccactcacggcccagggcagccagcag
taccgagccctctccgtggccgagctcacccagcagatgttcgatgcccgcaataccatg
gctgcctgtgacctccgccgtggccgctacctcacagtggcctgcattttccggggcaag
atgtccaccaaggaagtggaccagcaactgctctccgtgcagaccaggaacagcagctgc
tttgtggagtggattcccaacaacgtcaaggtggctgtctgcgacatcccgccccggggg
ctgagcatggccgccaccttcattggcaacaacacggccatccaagagatctttaatagg
gtctctgagcatttctcagccatgttcaaaaggaaagcttttgtgcactggtacaccagc
gaagggatggacataaacgaatttggggaagctgaaaataacatccatgatttggtatcc
gagtaccaacaatttcaagatgccaaagcagttctagaggaagatgaagaggtcacggag
gaggcagaaatggagccagaagataagggacattaa

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