| Entry |
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| Symbol |
TUBB3, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4
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| Name |
(RefSeq) tubulin beta 3 class III
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
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| Element |
| N00976 | Retrograde axonal transport |
| N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
| N00978 | Anterograde axonal transport |
| N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
| N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
| N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
| N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
| N01285 | Microtubule-RHOA signaling pathway |
| N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
| N01295 | Rab7-regulated microtubule minus-end directed transport |
| N01297 | Arl8-regulated microtubule plus-end directed transport |
| N01298 | Salmonella SifA to microtubule plus-end directed transport |
| N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
| N01403 | Zn to anterograde axonal transport |
| N01414 | Iron to anterograde axonal transport |
| N01535 | Kinetochore microtubule attachment |
| N01547 | Kinetochore fiber organization |
| N01549 | Branching microtubule nucleation |
| N01553 | Promotion of microtubule growth |
| N01561 | Microtubule depolymerization |
| N01562 | Microtubule depolymerization at the minus ends |
| N01832 | NTN1-MAP1B axon guidance signaling |
| N01833 | DRAXIN-MAP1B axon guidance signaling |
| N01834 | SEMA3A-MAP1B axon guidance signaling |
| N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
| N01836 | Microtubule plus end regulation network |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
| N01838 | Regulation of synaptic plasticity, p140Cap |
| N01839 | Severing of microtubule, SPAST/KATN |
| N01840 | Severing of microtubule, KIF2A |
| N01841 | Anterograde axonal transport, Kinesin-2 |
| N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
| N01843 | Anterograde dendrite transport, Kinesin-4 |
| N01844 | Anterograde dendrite transport, Kinesin-6 |
| N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
| N01846 | Retrograde axonal/dendrite transport, Dynein |
| N01857 | SEMA3A-DCX axon guidance signaling |
| N01858 | EFNB1-MAPT axon guidance signaling |
| N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
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| Disease |
| H00838 | Congenital fibrosis of the extraocular muscles |
| H01881 | Complex cortical dysplasia with other brain malformations |
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| Drug target |
| Brentuximab vedotin: | D09587<JP/US> |
| Denintuzumab mafodotin: | D11232 |
| Enfortumab vedotin: | D11525<JP/US> |
| Farletuzumab ecteribulin: | D12183 |
| Lorvotuzumab mertansine: | D09927 |
| Mirvetuximab soravtansine: | D10954<US> |
| Tasidotin hydrochloride: | D06009 |
| Trastuzumab emtansine: | D09980<JP/US> |
| Tusamitamab ravtansine: | D12310 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
10381 (TUBB3)
09142 Cell motility
04814 Motor proteins
10381 (TUBB3)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
10381 (TUBB3)
09164 Neurodegenerative disease
05010 Alzheimer disease
10381 (TUBB3)
05012 Parkinson disease
10381 (TUBB3)
05014 Amyotrophic lateral sclerosis
10381 (TUBB3)
05016 Huntington disease
10381 (TUBB3)
05020 Prion disease
10381 (TUBB3)
05022 Pathways of neurodegeneration - multiple diseases
10381 (TUBB3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
10381 (TUBB3)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
10381 (TUBB3)
04147 Exosome [BR:hsa04147]
10381 (TUBB3)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
10381 (TUBB3)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
10381 (TUBB3)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
10381 (TUBB3)
Exosomal proteins of colorectal cancer cells
10381 (TUBB3)
Exosomal proteins of bladder cancer cells
10381 (TUBB3)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
16:89921925..89936097
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| AA seq |
450 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK |
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| NT seq |
1353 nt +upstreamnt +downstreamnt
atgagggagatcgtgcacatccaggccggccagtgcggcaaccagatcggggccaagttc
tgggaagtcatcagtgatgagcatggcatcgaccccagcggcaactacgtgggcgactcg
gacttgcagctggagcggatcagcgtctactacaacgaggcctcttctcacaagtacgtg
cctcgagccattctggtggacctggaacccggaaccatggacagtgtccgctcaggggcc
tttggacatctcttcaggcctgacaatttcatctttggtcagagtggggccggcaacaac
tgggccaagggtcactacacggagggggcggagctggtggattcggtcctggatgtggtg
cggaaggagtgtgaaaactgcgactgcctgcagggcttccagctgacccactcgctgggg
ggcggcacgggctccggcatgggcacgttgctcatcagcaaggtgcgtgaggagtatccc
gaccgcatcatgaacaccttcagcgtcgtgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccacgctgtccatccaccagctggtggagaacacggatgagacctac
tgcatcgacaacgaggcgctctacgacatctgcttccgcaccctcaagctggccacgccc
acctacggggacctcaaccacctggtatcggccaccatgagcggagtcaccacctccttg
cgcttcccgggccagctcaacgctgacctgcgcaagctggccgtcaacatggtgcccttc
ccgcgcctgcacttcttcatgcccggcttcgcccccctcacagcccggggcagccagcag
taccgggccctgaccgtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggccaccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctggccatccagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaaggtggccgtgtgtgacatcccgccccgcggc
ctcaagatgtcctccaccttcatcgggaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgaggaagagggcgagatgtacgaagacgac
gaggaggagtcggaggcccagggccccaagtga |
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