| Entry |
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| Name |
Cyproheptadine hydrochloride (JP18/USP);
Cyproheptadine hydrochloride sesquihydrate;
Periactin (TN) |
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| Product |
|
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| Generic |
CYPROHEPTADINE (Chartwell RX), CYPROHEPTADINE HYDROCHLORIDE (A-S Medication Solutions), CYPROHEPTADINE HYDROCHLORIDE (A-S Medication Solutions), CYPROHEPTADINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), CYPROHEPTADINE HYDROCHLORIDE (AvPAK), CYPROHEPTADINE HYDROCHLORIDE (Bayshore Pharmaceuticals LLC), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Chartwell RX), CYPROHEPTADINE HYDROCHLORIDE (Golden State Medical Supply), CYPROHEPTADINE HYDROCHLORIDE (Ingenus Pharmaceuticals LLC), CYPROHEPTADINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Patrin Pharma), CYPROHEPTADINE HYDROCHLORIDE (Proficient Rx LP), CYPROHEPTADINE HYDROCHLORIDE (Proficient Rx LP), CYPROHEPTADINE HYDROCHLORIDE (QPharma), CYPROHEPTADINE HYDROCHLORIDE (QPharma), CYPROHEPTADINE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), CYPROHEPTADINE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharma Holdings), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharma Holdings), CYPROHEPTADINE HYDROCHLORIDE (Strides Pharma Science Limited), CYPROHEPTADINE HYDROCHLORIDE (TRUPHARMA), CYPROHEPTADINE HYDROCHLORIDE (Tris Pharma), CYPROHEPTADINE HYDROCHLORIDE (Westminster Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Zydus Lifesciences Limited), CYPROHEPTADINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), CYPROHEPTADINE HYDROCHLORIDE SOLUTION (Method Pharmaceuticals) |
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| Formula |
(C21H21N)2. 2HCl. 3H2O
|
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| Exact mass |
700.3198
|
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| Mol weight |
701.76
|
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| Structure |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
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| Remark |
| Therapeutic category: | 4419 |
| Product (DG01109): | D02234<JP/US> |
|
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| Efficacy |
Antiallergic, Antipruritic, H1 receptor antagonist, Serotonin receptor antagonist |
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| Disease |
Perennial and seasonal allergic rhinitis [DS: H01360] |
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| Comment |
Tricyclic, loratadine derivative
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
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| Interaction |
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX02 Cyproheptadine
D02234 Cyproheptadine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Cyproheptadine
D02234 Cyproheptadine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4419 Others
D02234 Cyproheptadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01109 Cyproheptadine
D02234 Cyproheptadine hydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D02234 Cyproheptadine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D02234 Cyproheptadine hydrochloride (JP18/USP) <JP/US>
Serotonin
HTR1
D02234 Cyproheptadine hydrochloride (JP18/USP) <JP/US>
HTR2
D02234 Cyproheptadine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02234 Cyproheptadine hydrochloride
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01109 Cyproheptadine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 49
1 X Cl 29.9601 -12.3900
2 O0 O 30.5201 -15.4700
3 C2x C 21.6757 -18.3177
4 C8y C 20.8313 -17.2050
5 C8y C 21.1674 -15.8445
6 C2y C 22.4319 -15.2648
7 C2x C 23.0854 -18.3430
8 C8y C 23.6889 -15.8888
9 C8y C 23.9762 -17.2613
10 C8x C 20.1575 -14.8734
11 C8x C 18.8118 -15.2626
12 C8x C 18.4757 -16.6231
13 C8x C 19.4856 -17.5939
14 C8x C 25.3110 -17.6996
15 C8x C 26.3581 -16.7626
16 C8x C 26.0710 -15.3901
17 C8x C 24.7359 -14.9518
18 C2y C 22.4319 -13.8648
19 C1x C 23.6222 -13.1772
20 C1x C 23.6218 -11.7772
21 N1y N 22.4092 -11.0775
22 C1x C 21.2189 -11.7651
23 C1x C 21.2193 -13.1651
24 C1a C 22.4089 -9.6600
25 X Cl 29.9601 -12.3900
26 O0 O 30.5201 -15.4700
27 O0 O 30.5201 -15.4700
28 C2x C 21.6757 -18.3177
29 C2x C 23.0854 -18.3430
30 C8y C 23.9762 -17.2613
31 C8y C 23.6889 -15.8888
32 C2y C 22.4319 -15.2648
33 C8y C 21.1674 -15.8445
34 C8y C 20.8313 -17.2050
35 C8x C 19.4856 -17.5939
36 C8x C 18.4757 -16.6231
37 C8x C 18.8118 -15.2626
38 C8x C 20.1575 -14.8734
39 C2y C 22.4319 -13.8648
40 C1x C 23.6222 -13.1772
41 C1x C 23.6218 -11.7772
42 N1y N 22.4092 -11.0775
43 C1x C 21.2189 -11.7651
44 C1x C 21.2193 -13.1651
45 C1a C 22.4089 -9.6600
46 C8x C 24.7359 -14.9518
47 C8x C 26.0710 -15.3901
48 C8x C 26.3581 -16.7626
49 C8x C 25.3110 -17.6996
BOND 50
1 5 6 1
2 3 7 2
3 6 8 1
4 4 5 1
5 7 9 1
6 3 4 1
7 8 9 1
8 5 10 2
9 10 11 1
10 11 12 2
11 12 13 1
12 4 13 2
13 9 14 2
14 14 15 1
15 15 16 2
16 16 17 1
17 8 17 2
18 6 18 2
19 18 19 1
20 19 20 1
21 20 21 1
22 21 22 1
23 22 23 1
24 18 23 1
25 21 24 1
26 33 32 1
27 28 29 2
28 32 31 1
29 34 33 1
30 29 30 1
31 28 34 1
32 31 30 1
33 33 38 2
34 38 37 1
35 37 36 2
36 36 35 1
37 34 35 2
38 30 49 2
39 49 48 1
40 48 47 2
41 47 46 1
42 31 46 2
43 32 39 2
44 39 40 1
45 40 41 1
46 41 42 1
47 42 43 1
48 43 44 1
49 39 44 1
50 42 45 1
BRACKET 1 28.2800 -13.3000 28.2800 -11.4100
1 30.9400 -11.4100 30.9400 -13.3000
1 2
ORIGINAL 1 1
REPEAT 1 25
2 28.3500 -16.3800 28.3500 -14.5600
2 31.3600 -14.5600 31.3600 -16.3800
2 3
ORIGINAL 2 2
REPEAT 2 26 27
3 18.2700 -18.7600 18.2700 -9.1700
3 26.9500 -9.1700 26.9500 -18.7600
3 2
ORIGINAL 3 3 7 9 8 6 5 4 13 12 11 10 18 19 20 21 22
3 23 24 17 16 15 14
REPEAT 3 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
3 44 45 46 47 48 49
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