KEGG   DRUG: Dantrolene sodium
Entry
D02274                      Drug                                   
Name
Dantrolene sodium (USP);
Dantrolene sodium hydrate (JP18);
Dantrium (TN);
Ryanodex (TN)
Product
DANTRIUM (ENDO USA), DANTRIUM (Endo USA), RYANODEX (Eagle Pharmaceuticals)
  Generic
DANTROLENE (Hikma Pharmaceuticals USA), DANTROLENE SODIUM (American Health Packaging), DANTROLENE SODIUM (Amneal Pharmaceuticals of New York LLC), DANTROLENE SODIUM (AvPAK), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Bryant Ranch Prepack), DANTROLENE SODIUM (Cardinal Health 107), DANTROLENE SODIUM (Elite Laboratories), DANTROLENE SODIUM (Endo USA), DANTROLENE SODIUM (Major Pharmaceuticals), REVONTO (ProPharma Distribution), REVONTO (USWM)
Formula
(C14H9N4O5. Na)2. 7H2O
Exact mass
798.1681
Mol weight
798.58
Structure
Class
Musculo-skeletal system agent
 DG02029  Muscle relaxant
Metabolizing enzyme substrate
 DG01891  CYP1A1 substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 1229
ATC code: M03CA01
Chemical structure group: DG00778
Product (DG00778): D02274<JP/US>
Efficacy
Skeletal muscle relaxant
  Disease
Cerebral palsy [DS:H01097]
Multiple sclerosis [DS:H01490]
Metabolism
Enzyme: CYP1A1 [HSA:1543], CYP1A2 [HSA:1544], CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03C MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS
    M03CA Dantrolene and derivatives
     M03CA01 Dantrolene
      D02274  Dantrolene sodium (USP) <JP/US>
USP drug classification [BR:br08302]
 Antispasticity Agents
  Dantrolene
   D02274  Dantrolene sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   122  Skeletal muscle relaxants
    1229  Others
     D02274  Dantrolene sodium (USP); Dantrolene sodium hydrate (JP18)
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG00778  Dantrolene
    D02274  Dantrolene sodium
 Metabolizing enzyme substrate
  DG01891  CYP1A1 substrate
   DG00778  Dantrolene
    D02274  Dantrolene sodium
  DG01892  CYP1A2 substrate
   DG00778  Dantrolene
    D02274  Dantrolene sodium
  DG01633  CYP3A/CYP3A4 substrate
   DG00778  Dantrolene
    D02274  Dantrolene sodium
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02274  Dantrolene sodium hydrate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02274
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02274
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02274
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG00778  Dantrolene
 Metabolizing enzyme substrate
  DG01891  CYP1A1 substrate
   DG00778  Dantrolene
  DG01892  CYP1A2 substrate
   DG00778  Dantrolene
  DG01633  CYP3A/CYP3A4 substrate
   DG00778  Dantrolene
Other DBs
CAS: 24868-20-0
PubChem: 7849333
LigandBox: D02274
LinkDB
KCF data

ATOM        55
            1   O0  O    34.0221  -15.2964
            2   C8y C    20.8070  -16.6600
            3   C8y C    19.5905  -15.9606
            4   O2x O    21.9470  -15.8312
            5   C8x C    21.2418  -17.9998
            6   C8x C    18.3741  -16.6600
            7   C8x C    19.5905  -14.5503
            8   C8y C    23.0871  -16.6600
            9   C8x C    22.6521  -17.9998
            10  C8x C    17.1578  -15.9606
            11  C8x C    18.3741  -13.8510
            12  C2b C    24.3033  -15.9606
            13  C8y C    17.1578  -14.5503
            14  N2b N    25.5257  -16.6600
            15  N2b N    15.9356  -13.8510 #+
            16  N1y N    26.8828  -15.9606
            17  O3a O    14.6724  -14.6441
            18  O3a O    15.9414  -12.4407 #-
            19  C1x C    28.0348  -16.5247
            20  C5x C    26.8948  -14.5503
            21  C5x C    28.9750  -15.4789
            22  N1x N    28.3167  -14.2624 #-
            23  O5x O    25.8547  -13.8914
            24  O5x O    30.2798  -15.4850
            25  Z   Na   28.2099  -12.8800 #+
            26  O0  O    34.0221  -15.2964
            27  O0  O    34.0221  -15.2964
            28  O0  O    34.0221  -15.2964
            29  O0  O    34.0221  -15.2964
            30  O0  O    34.0221  -15.2964
            31  O0  O    34.0221  -15.2964
            32  C8y C    20.8070  -16.6600
            33  C8y C    19.5905  -15.9606
            34  C8x C    18.3741  -16.6600
            35  C8x C    17.1578  -15.9606
            36  C8y C    17.1578  -14.5503
            37  N2b N    15.9356  -13.8510 #+
            38  O3a O    14.6724  -14.6441
            39  O3a O    15.9414  -12.4407 #-
            40  C8x C    18.3741  -13.8510
            41  C8x C    19.5905  -14.5503
            42  O2x O    21.9470  -15.8312
            43  C8y C    23.0871  -16.6600
            44  C2b C    24.3033  -15.9606
            45  N2b N    25.5257  -16.6600
            46  N1y N    26.8828  -15.9606
            47  C1x C    28.0348  -16.5247
            48  C5x C    28.9750  -15.4789
            49  O5x O    30.2798  -15.4850
            50  N1x N    28.3167  -14.2624 #-
            51  C5x C    26.8948  -14.5503
            52  O5x O    25.8547  -13.8914
            53  C8x C    22.6521  -17.9998
            54  C8x C    21.2418  -17.9998
            55  Z   Na   28.2099  -12.8800 #+
BOND        50
            1     2   3 1
            2     2   4 1
            3     2   5 2
            4     3   6 2
            5     3   7 1
            6     4   8 1
            7     5   9 1
            8     6  10 1
            9     7  11 2
            10    8  12 1
            11   10  13 2
            12   12  14 2
            13   13  15 1
            14   14  16 1
            15   15  17 2
            16   15  18 1
            17   16  19 1
            18   16  20 1
            19   19  21 1
            20   20  22 1
            21   20  23 2
            22   21  24 2
            23    8   9 2
            24   11  13 1
            25   21  22 1
            26   32  33 1
            27   32  42 1
            28   32  54 2
            29   33  34 2
            30   33  41 1
            31   42  43 1
            32   54  53 1
            33   34  35 1
            34   41  40 2
            35   43  44 1
            36   35  36 2
            37   44  45 2
            38   36  37 1
            39   45  46 1
            40   37  38 2
            41   37  39 1
            42   46  47 1
            43   46  51 1
            44   47  48 1
            45   51  50 1
            46   51  52 2
            47   48  49 2
            48   43  53 2
            49   40  36 1
            50   48  50 1
BRACKET     1    32.0600  -16.3100   32.0600  -14.2100
            1    34.5100  -14.2100   34.5100  -16.3100
            1  7
 ORIGINAL  1    1
 REPEAT    1   26  27  28  29  30  31
            2    14.2100  -18.2700   14.2100  -11.9000
            2    30.7300  -11.9000   30.7300  -18.2700
            2  2
 ORIGINAL  2    2   3   6  10  13  15  17  18  11   7   4   8  12  14  16  19
            2   21  24  22  20  23   9   5  25
 REPEAT    2   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            2   48  49  50  51  52  53  54  55

» Japanese version   » Back

DBGET integrated database retrieval system