KEGG   DRUG: Paroxetine
Entry
D02362                      Drug                                   
Name
Paroxetine (USP/INN);
Paroxetine (TN)
Formula
C19H20FNO3
Exact mass
329.1427
Mol weight
329.3654
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C07415
ATC code: N06AB05
Chemical structure group: DG00944
Product (DG00944): D02260<JP/US> D05374<US> D05375<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02362  Paroxetine (USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D02362  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D02362  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D02362  Paroxetine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D02362  Paroxetine (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02362
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
Other DBs
CAS: 61869-08-7
PubChem: 7849421
ChEBI: 7936
PDB-CCD: 8PR[PDBj]
LigandBox: D02362
NIKKAJI: J259.859K
LinkDB
KCF data

ATOM        24
            1   C1y C    24.7626  -18.6745
            2   C1y C    23.5491  -19.3721
            3   C8y C    24.7684  -17.3611
            4   C1x C    25.9759  -19.3721
            5   C1b C    22.3356  -18.6745
            6   C1x C    23.5491  -20.7791
            7   C8x C    25.9819  -16.6634
            8   C8x C    23.5549  -16.6634
            9   C1x C    25.9759  -20.7791
            10  O2a O    21.1161  -19.3721
            11  N1x N    24.7626  -21.4766
            12  C8x C    25.9819  -15.2624
            13  C8x C    23.5549  -15.2566
            14  C8y C    19.9026  -18.6686
            15  C8y C    24.7684  -14.5589
            16  C8x C    19.9086  -17.2733
            17  C8x C    18.6951  -19.3781
            18  X   F    24.7743  -13.2982
            19  C8y C    18.7008  -16.5699
            20  C8x C    17.4816  -18.6745
            21  C8y C    17.4816  -17.2733
            22  O2x O    18.4137  -15.1456
            23  O2x O    16.4848  -16.2829
            24  C1x C    16.9657  -14.8996
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1

» Japanese version   » Back

KEGG   DRUG: Paroxetine hydrochloride hemihydrate
Entry
D02260                      Drug                                   
Name
Paroxetine hydrochloride hemihydrate (USP);
Paroxetine hydrochloride hydrate (JP18);
Paxil (TN)
Product
  Generic
PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aurolife Pharma LLC), PAROXETINE (AvPAK), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cadila Pharmaceuticals Limited), PAROXETINE (Clinical Solutions Wholesale), PAROXETINE (Lupin Pharmaceuticals), PAROXETINE (McKesson Corporation dba SKY Packaging), PAROXETINE (Modavar Pharmaceuticals LLC), PAROXETINE (NCS HealthCare of KY), PAROXETINE (Northwind Pharmaceuticals), PAROXETINE (Novitium Pharma LLC), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (Yiling Pharmaceutical), PAROXETINE (Zydus Pharmaceuticals (USA)), PAROXETINE (American Health Packaging), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aurobindo Pharma Limited), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (NorthStar Rx LLC), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (Zydus Lifesciences Limited), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Denton Pharma), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (Mylan Pharmaceuticals), PAROXETINE (NCS HealthCare of KY), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (RPK Pharmaceuticals), PAROXETINE (Rhodes Pharmaceuticals L.P.), PAROXETINE (Solco Healthcare US)
Formula
(C19H20FNO3. HCl)2. H2O
Exact mass
748.2494
Mol weight
749.668
Structure
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 1179
ATC code: N06AB05
Chemical structure group: DG00944
Product (DG00944): D02260<JP/US> D05374<US> D05375<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Panic disorder [DS:H01664]
Social anxiety disorder [DS:H01670]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02260  Paroxetine hydrochloride hemihydrate (USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate (USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02260  Paroxetine hydrochloride hemihydrate (USP); Paroxetine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   D02260  Paroxetine hydrochloride hemihydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D02260  Paroxetine hydrochloride hemihydrate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02260  Paroxetine hydrochloride hydrate
  D02260  Paroxetine hydrochloride tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02260
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02260
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02260
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
Other DBs
PubChem: 7849319
LigandBox: D02260
LinkDB
KCF data

ATOM        51
            1   O0  O    41.1566  -17.6442
            2   C1y C    33.8100  -18.5500
            3   C1y C    32.5500  -19.2500
            4   C8y C    33.8100  -17.1500
            5   C1x C    35.0000  -19.2500
            6   C1b C    31.3600  -18.5500
            7   C1x C    32.5500  -20.6500
            8   C8x C    35.0000  -16.4500
            9   C8x C    32.5500  -16.4500
            10  C1x C    35.0000  -20.6500
            11  O2a O    30.1700  -19.2500
            12  N1x N    33.8100  -21.3500
            13  C8x C    35.0000  -15.0500
            14  C8x C    32.5500  -15.0500
            15  C8y C    28.9100  -18.5500
            16  C8y C    33.8100  -14.3500
            17  C8x C    28.9100  -17.1500
            18  C8x C    27.7200  -19.2500
            19  X   F    33.8100  -12.9500
            20  C8y C    27.7200  -16.4500
            21  C8x C    26.5300  -18.5500
            22  C8y C    26.5300  -17.1500
            23  O2x O    27.4400  -15.1200
            24  O2x O    25.4800  -16.2400
            25  C1x C    26.0400  -14.9100
            26  X   Cl   37.7300  -17.5700
            27  C1y C    33.8100  -18.5500
            28  C1y C    32.5500  -19.2500
            29  C1b C    31.3600  -18.5500
            30  O2a O    30.1700  -19.2500
            31  C8y C    28.9100  -18.5500
            32  C8x C    28.9100  -17.1500
            33  C8y C    27.7200  -16.4500
            34  C8y C    26.5300  -17.1500
            35  C8x C    26.5300  -18.5500
            36  C8x C    27.7200  -19.2500
            37  O2x O    25.4800  -16.2400
            38  C1x C    26.0400  -14.9100
            39  O2x O    27.4400  -15.1200
            40  C1x C    32.5500  -20.6500
            41  N1x N    33.8100  -21.3500
            42  C1x C    35.0000  -20.6500
            43  C1x C    35.0000  -19.2500
            44  C8y C    33.8100  -17.1500
            45  C8x C    35.0000  -16.4500
            46  C8x C    35.0000  -15.0500
            47  C8y C    33.8100  -14.3500
            48  C8x C    32.5500  -15.0500
            49  C8x C    32.5500  -16.4500
            50  X   F    33.8100  -12.9500
            51  X   Cl   37.7300  -17.5700
BOND        54
            1    14  16 1
            2    21  22 1
            3    24  25 1
            4     2   3 1
            5     2   4 1 #Down
            6     2   5 1
            7     3   6 1 #Up
            8     3   7 1
            9     4   8 2
            10    4   9 1
            11    5  10 1
            12    6  11 1
            13    7  12 1
            14    8  13 1
            15    9  14 2
            16   11  15 1
            17   13  16 2
            18   15  17 2
            19   15  18 1
            20   16  19 1
            21   17  20 1
            22   18  21 2
            23   20  22 2
            24   20  23 1
            25   22  24 1
            26   23  25 1
            27   10  12 1
            28   48  47 1
            29   35  34 1
            30   37  38 1
            31   27  28 1
            32   27  44 1 #Down
            33   27  43 1
            34   28  29 1 #Up
            35   28  40 1
            36   44  45 2
            37   44  49 1
            38   43  42 1
            39   29  30 1
            40   40  41 1
            41   45  46 1
            42   49  48 2
            43   30  31 1
            44   46  47 2
            45   31  32 2
            46   31  36 1
            47   47  50 1
            48   32  33 1
            49   36  35 2
            50   33  34 2
            51   33  39 1
            52   34  37 1
            53   39  38 1
            54   42  41 1
BRACKET     1    25.0600  -22.8200   25.0600  -12.2500
            1    38.5000  -12.2500   38.5000  -22.8200
            1  2
 ORIGINAL  1    2   3   6  11  15  17  20  22  21  18  24  25  23   7  12  10
            1    5   4   8  13  16  14   9  19  26
 REPEAT    1   27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42
            1   43  44  45  46  47  48  49  50  51

» Japanese version   » Back

KEGG   DRUG: Paroxetine hydrochloride
Entry
D05374                      Drug                                   
Name
Paroxetine hydrochloride (USP);
Paxil (TN)
Product
  Generic
Formula
C19H20FNO3. HCl
Exact mass
365.1194
Mol weight
365.8263
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: N06AB05
Chemical structure group: DG00944
Product (DG00944): D02260<JP/US> D05374<US> D05375<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Obsessive compulsive disorder [DS:H01450]
Panic disorder [DS:H01664]
Social anxiety disorder [DS:H01670]
Generalized anxiety disorder [DS:H01662]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05374  Paroxetine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   D05374  Paroxetine hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D05374  Paroxetine hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05374
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05374
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
Other DBs
CAS: 78246-49-8
PubChem: 47207050
ChEBI: 7944
LigandBox: D05374
NIKKAJI: J345.197F
LinkDB
KCF data

ATOM        25
            1   C1y C    25.2966  -20.5661
            2   C1y C    24.0856  -21.2622
            3   C8y C    25.3023  -19.1620
            4   C1x C    26.5074  -21.2622
            5   C1b C    22.8746  -20.5661
            6   C1x C    24.0856  -22.6663
            7   C8x C    26.5133  -18.4659
            8   C8x C    24.0913  -18.4659
            9   C1x C    26.5074  -22.6663
            10  O2a O    21.6576  -21.2622
            11  N1x N    25.2966  -23.3626
            12  C8x C    26.5133  -17.0677
            13  C8x C    24.0913  -17.0619
            14  C8y C    20.4465  -20.5601
            15  C8y C    25.3023  -16.3657
            16  C8x C    20.4525  -19.1679
            17  C8x C    19.2415  -21.2681
            18  X   F    25.2381  -14.9675
            19  C8y C    19.2472  -18.4659
            20  C8x C    18.0305  -20.5661
            21  C8y C    18.0305  -19.1679
            22  O2x O    18.9607  -17.0911
            23  O2x O    16.9891  -18.2260
            24  C1x C    17.5624  -16.9391
            25  X   Cl   29.5912  -22.1540
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1

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KEGG   DRUG: Paroxetine mesylate
Entry
D05375                      Drug                                   
Name
Paroxetine mesylate (USAN);
Brisdelle (TN);
Pexeva (TN)
Product
  Generic
Formula
C19H20FNO3. CH4SO3
Exact mass
425.1308
Mol weight
425.4711
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: N06AB05
Chemical structure group: DG00944
Product (DG00944): D02260<JP/US> D05374<US> D05375<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Obsessive compulsive disorder [DS:H01450]
Panic disorder [DS:H01664]
Generalized anxiety disorder [DS:H01662]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05375  Paroxetine mesylate (USAN) <US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D05375  Paroxetine mesylate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D05375  Paroxetine mesylate
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D05375  Paroxetine mesylate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   D05375  Paroxetine mesylate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D05375  Paroxetine mesylate (USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05375
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05375
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
Other DBs
CAS: 217797-14-3
PubChem: 47207051
LigandBox: D05375
LinkDB
KCF data

ATOM        29
            1   C1y C    10.4825   -8.1745
            2   C1y C     9.2690   -8.8721
            3   C8y C    10.4883   -6.8611
            4   C1x C    11.6958   -8.8721
            5   C1b C     8.0556   -8.1745
            6   C1x C     9.2690  -10.2791
            7   C8x C    11.7018   -6.1634
            8   C8x C     9.2748   -6.1634
            9   C1x C    11.6958  -10.2791
            10  O2a O     6.8361   -8.8721
            11  N1x N    10.4825  -10.9766
            12  C8x C    11.7018   -4.7624
            13  C8x C     9.2748   -4.7566
            14  C8y C     5.6226   -8.1686
            15  C8y C    10.4883   -4.0589
            16  C8x C     5.6286   -6.7733
            17  C8x C     4.4151   -8.8781
            18  X   F    10.4942   -2.7982
            19  C8y C     4.4208   -6.0699
            20  C8x C     3.2016   -8.1745
            21  C8y C     3.2016   -6.7733
            22  O2x O     4.1337   -4.6456
            23  O2x O     2.2048   -5.7829
            24  C1x C     2.6857   -4.3996
            25  O1d O    15.9383   -6.5271
            26  S4a S    15.9383   -7.9217
            27  C1a C    14.5438   -7.9217
            28  O1d O    17.3329   -7.9217
            29  O1d O    15.9383   -9.3162
BOND        31
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1
            28   25  26 2
            29   26  27 1
            30   26  28 1
            31   26  29 2

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