| Entry |
|
|---|
| Name |
Flibanserin (USAN/INN);
Addyi (TN)
|
|---|
| Product |
|
|---|
| Formula |
C20H21F3N4O
|
|---|
| Exact mass |
390.1667
|
|---|
| Mol weight |
390.4022
|
|---|
| Structure |
   |
|---|
| Class |
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidepressant, Serotonin 5-HT1A receptor agonist, Serotonin 5-HT2 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G02 OTHER GYNECOLOGICALS
G02C OTHER GYNECOLOGICALS
G02CX Other gynecologicals
G02CX02 Flibanserin
D02577 Flibanserin (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1A
D02577 Flibanserin (USAN/INN) <US>
HTR2
D02577 Flibanserin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02577
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02577
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D02577
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 28
1 C8x C 22.4700 -22.9600
2 C8y C 22.4700 -21.5600
3 C8x C 23.6600 -20.8600
4 C8y C 24.9200 -21.5600
5 C8x C 24.9200 -22.9600
6 C8x C 23.6600 -23.6600
7 N1y N 21.2800 -20.8600
8 C1x C 20.0900 -21.5600
9 C1x C 18.8300 -20.8600
10 N1y N 18.8300 -19.4600
11 C1x C 20.0200 -18.7600
12 C1x C 21.2800 -19.4600
13 C1b C 17.6400 -18.7600
14 C1b C 16.3800 -19.4600
15 N4y N 15.1900 -18.7600
16 C8y C 13.3700 -17.4300
17 C8y C 14.7700 -17.4300
18 C8y C 14.0700 -19.6000
19 N4x N 12.9500 -18.7600
20 C8x C 15.4700 -16.2176
21 C8x C 14.7700 -15.0051
22 C8x C 13.3700 -15.0051
23 C8x C 12.6700 -16.2176
24 O5x O 14.0700 -21.0000
25 C1d C 26.1266 -20.8500
26 X F 27.3000 -20.1600
27 X F 26.8100 -22.0500
28 X F 25.4100 -19.6700
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 2 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 7 12 1
14 10 13 1
15 13 14 1
16 14 15 1
17 16 17 2
18 17 15 1
19 15 18 1
20 18 19 1
21 16 19 1
22 17 20 1
23 20 21 2
24 21 22 1
25 22 23 2
26 16 23 1
27 18 24 2
28 4 25 1
29 25 26 1
30 25 27 1
31 25 28 1
|
|---|
