KEGG   DRUG: Flibanserin
Entry
D02577                      Drug                                   
Name
Flibanserin (USAN/INN);
Addyi (TN)
Product
ADDYI (Sprout Pharmaceuticals)
Formula
C20H21F3N4O
Exact mass
390.1667
Mol weight
390.40
Structure
Class
Neuropsychiatric agent
 DG01483  5-HT1A-receptor agonist
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: G02CX02
Product: D02577<US>
Efficacy
Antidepressant, Serotonin 5-HT1A receptor agonist, Serotonin 5-HT2 receptor antagonist
Comment
Treatment of female sexual dysfunction
Target
HTR1A [HSA:3350] [KO:K04153]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CX Other gynecologicals
     G02CX02 Flibanserin
      D02577  Flibanserin (USAN/INN) <US>
USP drug classification [BR:br08302]
 Sexual Disorder Agents
  Sexual Disorder Agents (Female)
   Flibanserin
    D02577  Flibanserin (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01483  5-HT1A-receptor agonist
   D02577  Flibanserin
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D02577  Flibanserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D02577  Flibanserin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1A
     D02577  Flibanserin (USAN/INN) <US>
    HTR2
     D02577  Flibanserin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02577
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02577
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02577
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02577
Other DBs
CAS: 167933-07-5
PubChem: 17396748
ChEBI: 90865
LigandBox: D02577
LinkDB
KCF data

ATOM        28
            1   C8x C    22.4700  -22.9600
            2   C8y C    22.4700  -21.5600
            3   C8x C    23.6600  -20.8600
            4   C8y C    24.9200  -21.5600
            5   C8x C    24.9200  -22.9600
            6   C8x C    23.6600  -23.6600
            7   N1y N    21.2800  -20.8600
            8   C1x C    20.0900  -21.5600
            9   C1x C    18.8300  -20.8600
            10  N1y N    18.8300  -19.4600
            11  C1x C    20.0200  -18.7600
            12  C1x C    21.2800  -19.4600
            13  C1b C    17.6400  -18.7600
            14  C1b C    16.3800  -19.4600
            15  N4y N    15.1900  -18.7600
            16  C8y C    13.3700  -17.4300
            17  C8y C    14.7700  -17.4300
            18  C8y C    14.0700  -19.6000
            19  N4x N    12.9500  -18.7600
            20  C8x C    15.4700  -16.2176
            21  C8x C    14.7700  -15.0051
            22  C8x C    13.3700  -15.0051
            23  C8x C    12.6700  -16.2176
            24  O5x O    14.0700  -21.0000
            25  C1d C    26.1266  -20.8500
            26  X   F    27.3000  -20.1600
            27  X   F    26.8100  -22.0500
            28  X   F    25.4100  -19.6700
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   16  17 2
            18   17  15 1
            19   15  18 1
            20   18  19 1
            21   16  19 1
            22   17  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   16  23 1
            27   18  24 2
            28    4  25 1
            29   25  26 1
            30   25  27 1
            31   25  28 1

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