KEGG   DRUG: RamelteonHelp
Entry
D02689                      Drug                                   

Name
Ramelteon (JAN/USAN/INN);
Rozerem (TN)
Product
Formula
C16H21NO2
Exact mass
259.1572
Mol weight
259.3434
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01589  Melatonin receptor agonist
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1190
ATC code: N05CH02
Product: D02689<JP/US>
Efficacy
Hypnotic, Melatonin receptor agonist
  Disease
Insomnia [DS:H01609]
Comment
Treatment of sleep disorders
Target
MTNR1 [HSA:4543 4544] [KO:K04285 K04286]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2C [HSA:1557 1559 1558 1562], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07032  Hypnotics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CH Melatonin receptor agonists
     N05CH02 Ramelteon
      D02689  Ramelteon (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Disorders, Other
   Ramelteon
    D02689  Ramelteon (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02689  Ramelteon (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Melatonin
    MTNR1
     D02689  Ramelteon (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D02689
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02689
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02689
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02689
BRITE hierarchy
Other DBs
CAS: 196597-26-9
PubChem: 17396858
ChEMBL: CHEMBL1218
DrugBank: DB00980
LigandBox: D02689
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    20.8600  -14.7700
            2   C8x C    20.8600  -16.1700
            3   C8x C    22.0724  -16.8700
            4   C8y C    23.2849  -16.1700
            5   C8y C    23.2849  -14.7700
            6   C8y C    22.0724  -14.0700
            7   C1x C    21.7814  -12.7006
            8   C1x C    20.3890  -12.5542
            9   O2x O    19.8196  -13.8332
            10  C1x C    24.6164  -16.6026
            11  C1x C    25.4393  -15.4700
            12  C1y C    24.6164  -14.3374
            13  C1b C    25.0475  -13.0106
            14  C1b C    26.2724  -12.3200
            15  N1b N    27.4849  -13.0200
            16  C5a C    28.6973  -12.3200
            17  C1b C    29.9097  -13.0200
            18  C1a C    31.1222  -12.3200
            19  O5a O    28.6973  -10.9200
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    1   9 1
            11    4  10 1
            12   10  11 1
            13   11  12 1
            14    5  12 1
            15   12  13 1 #Down
            16   13  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   16  19 2

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