KEGG   DRUG: Ramelteon
Entry
D02689                      Drug                                   

Name
Ramelteon (JAN/USAN/INN);
Rozerem (TN)
Product
  Generic
Formula
C16H21NO2
Exact mass
259.1572
Mol weight
259.3434
Structure
Class
Neuropsychiatric agent
 DG01589  Melatonin receptor agonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1190
ATC code: N05CH02
Product: D02689<JP/US>
Efficacy
Hypnotic, Melatonin receptor agonist
  Disease
Insomnia [DS:H01609]
Comment
Treatment of sleep disorders
Target
MTNR1 [HSA:4543 4544] [KO:K04285 K04286]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Structure map
map07032  Hypnotics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CH Melatonin receptor agonists
     N05CH02 Ramelteon
      D02689  Ramelteon (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Promoting Agents
   Ramelteon
    D02689  Ramelteon (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02689  Ramelteon (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Melatonin
    MTNR1
     D02689  Ramelteon (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02689
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02689
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02689
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02689
Other DBs
CAS: 196597-26-9
PubChem: 17396858
ChEMBL: CHEMBL1218
DrugBank: DB00980
PDB-CCD: JEV[PDBj]
LigandBox: D02689
LinkDB
KCF data

ATOM        19
            1   C8y C    20.8600  -14.7700
            2   C8x C    20.8600  -16.1700
            3   C8x C    22.0724  -16.8700
            4   C8y C    23.2849  -16.1700
            5   C8y C    23.2849  -14.7700
            6   C8y C    22.0724  -14.0700
            7   C1x C    21.7814  -12.7006
            8   C1x C    20.3890  -12.5542
            9   O2x O    19.8196  -13.8332
            10  C1x C    24.6164  -16.6026
            11  C1x C    25.4393  -15.4700
            12  C1y C    24.6164  -14.3374
            13  C1b C    25.0475  -13.0106
            14  C1b C    26.2724  -12.3200
            15  N1b N    27.4849  -13.0200
            16  C5a C    28.6973  -12.3200
            17  C1b C    29.9097  -13.0200
            18  C1a C    31.1222  -12.3200
            19  O5a O    28.6973  -10.9200
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    1   9 1
            11    4  10 1
            12   10  11 1
            13   11  12 1
            14    5  12 1
            15   12  13 1 #Down
            16   13  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   16  19 2

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