| Entry |
|
|---|
| Name |
Ramelteon (JAN/USAN/INN);
Rozerem (TN) |
|---|
| Product |
|
|---|
| Generic |
RAMELTEON (Actavis Pharma), RAMELTEON (AvKARE), RAMELTEON (AvPAK), RAMELTEON (Bryant Ranch Prepack), RAMELTEON (Cadila Healthcare Limited), RAMELTEON (DIRECT RX), RAMELTEON (Dr.Reddys Laboratories), RAMELTEON (Golden State Medical Supply), RAMELTEON (Granules Pharmaceuticals), RAMELTEON (Quality Care Products), RAMELTEON (TruPharma), RAMELTEON (Upsher-Smith Laboratories), RAMELTEON (Zydus Pharmaceuticals (USA)), RAMELTEON (i3 Pharmaceuticals) |
|---|
| Formula |
C16H21NO2
|
|---|
| Exact mass |
259.1572
|
|---|
| Mol weight |
259.3434
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01589 Melatonin receptor agonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Therapeutic category: | 1190 |
|
|---|
| Efficacy |
Hypnotic, Melatonin receptor agonist |
|---|
| Disease |
|
|---|
| Comment |
Treatment of sleep disorders
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CH Melatonin receptor agonists
N05CH02 Ramelteon
D02689 Ramelteon (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Sleep Promoting Agents
Ramelteon
D02689 Ramelteon (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D02689 Ramelteon (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Melatonin
MTNR1
D02689 Ramelteon (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02689
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02689
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02689
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02689
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 19
1 C8y C 20.8600 -14.7700
2 C8x C 20.8600 -16.1700
3 C8x C 22.0724 -16.8700
4 C8y C 23.2849 -16.1700
5 C8y C 23.2849 -14.7700
6 C8y C 22.0724 -14.0700
7 C1x C 21.7814 -12.7006
8 C1x C 20.3890 -12.5542
9 O2x O 19.8196 -13.8332
10 C1x C 24.6164 -16.6026
11 C1x C 25.4393 -15.4700
12 C1y C 24.6164 -14.3374
13 C1b C 25.0475 -13.0106
14 C1b C 26.2724 -12.3200
15 N1b N 27.4849 -13.0200
16 C5a C 28.6973 -12.3200
17 C1b C 29.9097 -13.0200
18 C1a C 31.1222 -12.3200
19 O5a O 28.6973 -10.9200
BOND 21
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 1 9 1
11 4 10 1
12 10 11 1
13 11 12 1
14 5 12 1
15 12 13 1 #Down
16 13 14 1
17 14 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 16 19 2
|
|---|
