| Entry |
|
|---|
| Name |
Ramelteon (JAN/USAN/INN);
Rozerem (TN)
|
|---|
| Product |
|
|---|
| Formula |
C16H21NO2
|
|---|
| Exact mass |
259.1572
|
|---|
| Mol weight |
259.3434
|
|---|
| Structure |
   |
|---|
| Class |
Neuropsychiatric agent
DG01589 Melatonin receptor agonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Therapeutic category: | 1190 |
|
|---|
| Efficacy |
Hypnotic, Melatonin receptor agonist |
|---|
| Disease |
|
|---|
| Comment |
Treatment of sleep disorders
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CH Melatonin receptor agonists
N05CH02 Ramelteon
D02689 Ramelteon (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Sleep Disorders, Other
Ramelteon
D02689 Ramelteon (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D02689 Ramelteon (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Melatonin
MTNR1
D02689 Ramelteon (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02689
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02689
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02689
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 19
1 C8y C 20.8600 -14.7700
2 C8x C 20.8600 -16.1700
3 C8x C 22.0724 -16.8700
4 C8y C 23.2849 -16.1700
5 C8y C 23.2849 -14.7700
6 C8y C 22.0724 -14.0700
7 C1x C 21.7814 -12.7006
8 C1x C 20.3890 -12.5542
9 O2x O 19.8196 -13.8332
10 C1x C 24.6164 -16.6026
11 C1x C 25.4393 -15.4700
12 C1y C 24.6164 -14.3374
13 C1b C 25.0475 -13.0106
14 C1b C 26.2724 -12.3200
15 N1b N 27.4849 -13.0200
16 C5a C 28.6973 -12.3200
17 C1b C 29.9097 -13.0200
18 C1a C 31.1222 -12.3200
19 O5a O 28.6973 -10.9200
BOND 21
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 1 9 1
11 4 10 1
12 10 11 1
13 11 12 1
14 5 12 1
15 12 13 1 #Down
16 13 14 1
17 14 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 16 19 2
|
|---|
