| Entry |
|
|---|
| Name |
Somatropin (USP/INN);
Somatropin (genetical recombination) (JAN);
Human growth hormone (JAN);
Asellacrin (TN);
Nutropin (TN);
Omnitrope (TN)
|
|---|
| Product |
|
|---|
| Formula |
C990H1528N262O300S7
|
|---|
| Exact mass |
22111.0409
|
|---|
| Mol weight |
22124.7557
|
|---|
| Sequence |
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
QCRSVEGSCG F
(Disulfide bridge: 53-165, 182-189) |
|---|
| Type |
Peptide |
|---|
| Class |
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 2412 |
|
|---|
| Efficacy |
Growth hormone (GH) receptor agonist |
|---|
| Disease |
HIV patient [DS: H01563] Growth hormone deficiency [DS: H00254] |
|---|
| Comment |
human growth hormone derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557]
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
H01AC Somatropin and somatropin agonists
H01AC01 Somatropin
D02691 Somatropin (USP/INN) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Gastrointestinal Agents, Other
Short Bowel Syndrome Agents
Somatropin
D02691 Somatropin (USP/INN)
Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
Somatropin, Recombinant
D02691 Somatropin (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
241 Pituitary hormone preparations
2412 Anterior pituitary hormones
D02691 Somatropin (USP/INN); Somatropin (genetical recombination) (JAN); Human growth hormone (JAN)
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
Cytokine receptors
CSF and other factor receptors
GHR
D02691 Somatropin (USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02691
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02691
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| Other DBs |
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| LinkDB |
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