KEGG   DRUG: Lidocaine and prilocaine
Entry
D02740            Mixture   Drug                                   
Name
Lidocaine and prilocaine;
Lidocaine and propitocaine;
Emla (TN);
Oraqix (TN);
Lidocaine and prilocaine (TN)
Product
ORAQIX (Dentsply Pharmaceutical)
  Generic
EMREAL (Forreal Pharmaceuticals LLC), LIDOCAINE AND PRILOCAINE (A-S Medication Solutions), LIDOCAINE AND PRILOCAINE (Actavis Pharma), LIDOCAINE AND PRILOCAINE (Alembic Pharmaceuticals), LIDOCAINE AND PRILOCAINE (Bryant Ranch Prepack), LIDOCAINE AND PRILOCAINE (Bryant Ranch Prepack), LIDOCAINE AND PRILOCAINE (E. Fougera & Co. a division of Fougera Pharmaceuticals), LIDOCAINE AND PRILOCAINE (Kesin Pharma Corporation), LIDOCAINE AND PRILOCAINE (NuCare Pharamceuticals), LIDOCAINE AND PRILOCAINE (Padagis US LLC), LIDOCAINE AND PRILOCAINE (Preferred Pharmaceuticals), LIDOCAINE AND PRILOCAINE (Proficient Rx LP), LIDOCAINE AND PRILOCAINE (Rhodes Pharmaceuticals L.P.)
Component
Lidocaine [DR:D00358], Prilocaine [DR:D00553]
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1219
ATC code: N01BB52 N01BB54
Product: D02740<JP/US>
Efficacy
Anesthetic (topical)
Comment
Lidocaine is primarily metabolized by CYP1A2 and CYP3A4.
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB52 Lidocaine, combinations
      D02740  Lidocaine and prilocaine <JP/US>
     N01BB54 Prilocaine, combinations
      D02740  Lidocaine and prilocaine <JP/US>
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine/ Prilocaine
    D02740  Lidocaine and prilocaine
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1219  Others
     D02740  Lidocaine and prilocaine
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D02740  Lidocaine and prilocaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D02740  Lidocaine and prilocaine
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02740
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02740
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02740
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02740
Other DBs
CAS: 101362-25-8
PubChem: 47205816
LinkDB

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