KEGG   DRUG: PrilocaineHelp
Entry
D00553                      Drug                                   

Name
Prilocaine (USP/INN);
Propitocaine (JAN)
Formula
C13H20N2O
Exact mass
220.1576
Mol weight
220.3107
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Remark
Same as: C07531
ATC code: N01BB04
Chemical structure group: DG00803
Product (DG00803): D01243<US>
Product (mixture): D02740<JP/US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB04 Prilocaine
      D00553  Prilocaine (USP/INN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Prilocaine
   D00553  Prilocaine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00553  Prilocaine (USP/INN)
    SCN2A
     D00553  Prilocaine (USP/INN)
    SCN3A
     D00553  Prilocaine (USP/INN)
    SCN4A
     D00553  Prilocaine (USP/INN)
    SCN5A
     D00553  Prilocaine (USP/INN)
    SCN8A
     D00553  Prilocaine (USP/INN)
    SCN9A
     D00553  Prilocaine (USP/INN)
    SCN10A
     D00553  Prilocaine (USP/INN)
    SCN11A
     D00553  Prilocaine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 721-50-6
PubChem: 7847619
ChEBI: 8404
ChEMBL: CHEMBL1194
DrugBank: DB00750
LigandBox: D00553
NIKKAJI: J6.949C
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8y C    19.9828  -18.3051
            2   N1b N    21.2173  -19.0214
            3   C8y C    18.7484  -19.0272
            4   C8x C    19.9828  -16.8786
            5   C5a C    22.4459  -18.2935
            6   C8x C    17.5198  -18.3051
            7   C1a C    18.7601  -20.4420
            8   C8x C    18.7484  -16.1683
            9   C1c C    23.6686  -19.0214
            10  O5a O    22.5042  -17.2164
            11  C8x C    17.5198  -16.8786
            12  N1b N    24.9029  -18.2935
            13  C1a C    23.6628  -20.4130
            14  C1b C    26.1432  -19.0214
            15  C1b C    27.3601  -18.2935
            16  C1a C    28.5770  -18.9806
BOND        16
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 2
            10    6  11 2
            11    9  12 1
            12    9  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 1
            16    8  11 1

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