KEGG   DRUG: Certolizumab pegol
Entry
D03441                      Drug                                   
Name
Certolizumab pegol (USAN/INN);
Certolizumab pegol (genetical recombination) (JAN);
Cimzia (TN)
Product
CIMZIA (UCB)
Formula
C2115H3252N556O673S16
Exact mass
47719.2868
Mol weight
47748.84
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG01936  TNF inhibitor
Remark
Therapeutic category: 3999
ATC code: L04AB05
Product: D03441<JP/US>
Efficacy
Anti-inflammatory, Antirheumatic, Anti-TNF-alpha antibody
  Disease
Crohn's disease [DS:H00286]
Rheumatoid arthritis [DS:H00630]
Psoriatic arthritis [DS:H01507]
Ankylosing spondylitis [DS:H01674]
  Type
Monoclonal antibody
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04920  Adipocytokine signaling pathway
hsa05323  Rheumatoid arthritis
Interaction
Structure map
map07050  Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors
     L04AB05 Certolizumab pegol
      D03441  Certolizumab pegol (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunosuppressants
   Tumor Necrosis Factor (TNF) Blockers
    Certolizumab Pegol
     D03441  Certolizumab pegol (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03441  Certolizumab pegol (USAN/INN); Certolizumab pegol (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG01936  TNF inhibitor
    D03441  Certolizumab pegol
Drug classes [BR:br08332]
 Immunological agent
  DG01936  TNF inhibitor
   D03441  Certolizumab pegol
 Antirheumatic agent
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   D03441  Certolizumab pegol
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D03441  Certolizumab pegol (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03441
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03441
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03441
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03441
Other DBs
CAS: 428863-50-7
PubChem: 17397581
LinkDB

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