KEGG   DISEASE: Seronegative arthritis
H01507                      Disease                                
Seronegative arthritis
Ankylosing spondylosis
Undifferentiated spondylarthritis
Reactive arthritis
Psoriatic arthritis
Enteropathic arthritis
Seronegative spondyloarthropathies (SpA) represent a group of chronic articular inflammatory diseases which differ from rheumatoid arthritis for the typical absence of rheumatoid factor in serum, and have in common several epidemiological, pathological, clinical, and radiological features. SpA include ankylosing spondylitis (AS), reactive arthritis (ReA), enteropathic (IBD) associated arthritis, psoriatic arthritis (PsA), as well as undifferentiated, and juvenile SpA. The main clinical manifestations include inflammatory back pain, peripheral arthritis, enthesitis, and extra-skeletal manifestations, such as uveitis. Although the cause of SpA is unknown, it is generally accepted that SpA is a multifactorial disease. Genetics (such as HLA-B27), inflammatory cytokines (such as TNF), and more recently the IL-23/IL-17 cytokine pathway have links to pathogenesis. Biologic agents, particularly TNF blockers, are primary treatment options and have been shown to reduce symptomatic inflammation.
Immune system disease
Human diseases in ICD-11 classification [BR:br08403]
 15 Diseases of the musculoskeletal system or connective tissue
   Inflammatory arthropathies
    FA27  Certain specified inflammatory arthropathies
     H01507  Seronegative arthritis
hsa04612  Antigen processing and presentation
HLA-B [HSA:3106] [KO:K06751]
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Abatacept [DR:D03203]
Apremilast [DR:D08860]
Upadacitinib hydrate [DR:D11048]
Etanercept [DR:D00742]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Certolizumab pegol [DR:D03441]
Golimumab [DR:D04358]
Ustekinumab [DR:D09214]
Secukinumab [DR:D09967]
Risankizumab [DR:D11052]
Other DBs
ICD-11: FA27.Y
MeSH: D025241
OMIM: 106300
Paparo F, Revelli M, Semprini A, Camellino D, Garlaschi A, Cimmino MA, Rollandi GA, Leone A
Seronegative spondyloarthropathies: what radiologists should know.
Radiol Med 119:156-63 (2014)
Wilson G, Folzenlogen DD
Spondyloarthropathies: new directions in etiopathogenesis, diagnosis and treatment.
Mo Med 109:69-74 (2012)
Melis L, Elewaut D
Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease?
Arthritis Res Ther 11:233 (2009)

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