KEGG   DRUG: Cifenline
Entry
D03492                      Drug                                   
Name
Cifenline (USAN);
Cibenzoline (INN)
Formula
C18H18N2
Exact mass
262.147
Mol weight
262.3489
Structure
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: C01BG07
Chemical structure group: DG00209
Product (DG00209): D01455<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG07 Cibenzoline
      D03492  Cifenline (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00209  Cibenzoline
      D03492  Cifenline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00209  Cibenzoline
    D03492  Cifenline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00209  Cibenzoline
     D03492  Cifenline
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D03492  Cifenline (USAN)
    SCN2A
     D03492  Cifenline (USAN)
    SCN3A
     D03492  Cifenline (USAN)
    SCN4A
     D03492  Cifenline (USAN)
    SCN5A
     D03492  Cifenline (USAN)
    SCN8A
     D03492  Cifenline (USAN)
    SCN9A
     D03492  Cifenline (USAN)
    SCN10A
     D03492  Cifenline (USAN)
    SCN11A
     D03492  Cifenline (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03492
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00209  Cibenzoline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00209  Cibenzoline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00209  Cibenzoline
Other DBs
CAS: 53267-01-9
PubChem: 17397628
LigandBox: D03492
NIKKAJI: J10.744A
LinkDB
KCF data

ATOM        20
            1   C8x C    19.5019  -17.1162
            2   C8x C    19.5019  -18.5190
            3   C8x C    20.6944  -19.2204
            4   C8x C    21.9569  -18.5190
            5   C8y C    21.9569  -17.1162
            6   C8x C    20.6944  -16.4147
            7   C1z C    23.1494  -16.4119
            8   C1x C    22.4479  -15.2195
            9   C1y C    23.8508  -15.2195
            10  C2y C    25.0690  -14.5198
            11  N2x N    26.3857  -14.9249
            12  C1x C    27.1780  -13.7977
            13  C1x C    26.3508  -12.6959
            14  N1x N    25.0473  -13.1422
            15  C8x C    24.3418  -18.5190
            16  C8y C    24.3418  -17.1162
            17  C8x C    25.6044  -19.2204
            18  C8x C    26.7968  -18.5190
            19  C8x C    26.7968  -17.1162
            20  C8x C    25.6044  -16.4147
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     8   9 1
            8     9   7 1
            9     7   8 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    5   7 1
            17   15  16 1
            18   15  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   16  20 2
            23    7  16 1

» Japanese version   » Back

KEGG   DRUG: Cifenline succinate
Entry
D01455                      Drug                                   
Name
Cifenline succinate (USAN);
Cibenzoline succinate (JP18);
Cibenol (TN);
Cipralan (TN)
Formula
C18H18N2. C4H6O4
Exact mass
380.1736
Mol weight
380.437
Structure
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2129
ATC code: C01BG07
Chemical structure group: DG00209
Product (DG00209): D01455<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG07 Cibenzoline
      D01455  Cifenline succinate (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01455  Cifenline succinate (USAN); Cibenzoline succinate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00209  Cibenzoline
      D01455  Cifenline succinate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00209  Cibenzoline
    D01455  Cifenline succinate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00209  Cibenzoline
     D01455  Cifenline succinate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D01455  Cifenline succinate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01455  Cifenline succinate (USAN) <JP>
    SCN2A
     D01455  Cifenline succinate (USAN) <JP>
    SCN3A
     D01455  Cifenline succinate (USAN) <JP>
    SCN4A
     D01455  Cifenline succinate (USAN) <JP>
    SCN5A
     D01455  Cifenline succinate (USAN) <JP>
    SCN8A
     D01455  Cifenline succinate (USAN) <JP>
    SCN9A
     D01455  Cifenline succinate (USAN) <JP>
    SCN10A
     D01455  Cifenline succinate (USAN) <JP>
    SCN11A
     D01455  Cifenline succinate (USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01455  Cibenzoline succinate
  D01455  Cibenzoline succinate tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01455
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00209  Cibenzoline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00209  Cibenzoline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00209  Cibenzoline
Other DBs
CAS: 100678-32-8
PubChem: 7848518
ChEBI: 31396
LigandBox: D01455
NIKKAJI: J364.406E
LinkDB
KCF data

ATOM        28
            1   O6a O    28.6206  -16.4110
            2   C6a C    29.8130  -17.1124
            3   C1b C    31.0755  -16.4110
            4   C1b C    32.2680  -17.1124
            5   C6a C    33.4604  -16.4110
            6   O6a O    34.7230  -17.1124
            7   O6a O    29.8130  -18.5153
            8   O6a O    33.4604  -15.0081
            9   C8x C    19.5021  -17.8163
            10  C8x C    19.5021  -19.2191
            11  C8x C    20.6946  -19.9206
            12  C8x C    21.9571  -19.2191
            13  C8y C    21.9571  -17.8163
            14  C8x C    20.6946  -17.1148
            15  C1z C    23.1496  -17.1120
            16  C1x C    22.4481  -15.9196
            17  C1y C    23.8510  -15.9196
            18  C2y C    25.0692  -15.2199
            19  N2x N    26.3859  -15.6250
            20  C1x C    27.1782  -14.4978
            21  C1x C    26.3510  -13.3960
            22  N1x N    25.0475  -13.8423
            23  C8x C    24.3420  -19.2191
            24  C8y C    24.3420  -17.8163
            25  C8x C    25.6046  -19.9206
            26  C8x C    26.7970  -19.2191
            27  C8x C    26.7970  -17.8163
            28  C8x C    25.6046  -17.1148
BOND        30
            1     2   7 2
            2     5   8 2
            3     3   4 1
            4     1   2 1
            5     4   5 1
            6     5   6 1
            7     2   3 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   16  17 1
            15   17  15 1
            16   15  16 1
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   18  22 1
            23   13  15 1
            24   23  24 1
            25   23  25 2
            26   25  26 1
            27   26  27 2
            28   27  28 1
            29   24  28 2
            30   15  24 1

» Japanese version   » Back

DBGET integrated database retrieval system