KEGG   DRUG: Dexmethylphenidate hydrochloride
Entry
D03721                      Drug                                   
Name
Dexmethylphenidate hydrochloride (USAN);
Focalin (TN)
Product
FOCALIN (Novartis Pharmaceuticals Corporation), FOCALIN (Novartis Pharmaceuticals Corporation), FOCALIN (Sandoz), FOCALIN (Sandoz)
  Generic
DEXMETHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), DEXMETHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), DEXMETHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), DEXMETHYLPHENIDATE HYDROCHLORIDE (Ascend Laboratories), DEXMETHYLPHENIDATE HYDROCHLORIDE (Ascent Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), DEXMETHYLPHENIDATE HYDROCHLORIDE (Camber Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Cranbury Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Endo USA), DEXMETHYLPHENIDATE HYDROCHLORIDE (Granules Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (KVK-TECH), DEXMETHYLPHENIDATE HYDROCHLORIDE (Lannett Company), DEXMETHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Neolpharma), DEXMETHYLPHENIDATE HYDROCHLORIDE (Nivagen Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Northstar Rx LLC), DEXMETHYLPHENIDATE HYDROCHLORIDE (Par Pharmaceuticals), DEXMETHYLPHENIDATE HYDROCHLORIDE (Sandoz), DEXMETHYLPHENIDATE HYDROCHLORIDE (Sun Pharmaceutical Industries), DEXMETHYLPHENIDATE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C14H19NO2. HCl
Exact mass
269.1183
Mol weight
269.77
Structure
Simcomp
Remark
ATC code: N06BA11
Chemical structure group: DG00972
Product (DG00972): D03721<US>
Product (mixture): D11989<US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Comment
Treatment of attention deficit/ hyperactivity disorder (ADHD)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA11 Dexmethylphenidate
      D03721  Dexmethylphenidate hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Dexmethylphenidate
    D03721  Dexmethylphenidate hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D03721  Dexmethylphenidate hydrochloride (USAN) <US>
    SLC6A3 (DAT1)
     D03721  Dexmethylphenidate hydrochloride (USAN) <US>
    SLC6A4 (HTT)
     D03721  Dexmethylphenidate hydrochloride (USAN) <US>
Other DBs
CAS: 19262-68-1
PubChem: 17397812
LigandBox: D03721
LinkDB
KCF data

ATOM        18
            1   C1c C    32.6431  -17.9493
            2   C1y C    31.4433  -17.2330
            3   C7a C    33.8664  -17.2563
            4   C1x C    30.2259  -17.9203
            5   N1x N    31.4607  -15.8350
            6   O7a O    33.8838  -15.8583
            7   O6a O    35.0721  -17.9726
            8   C1x C    29.0202  -17.2096
            9   C1x C    30.2549  -15.1185
            10  C1a C    35.1012  -15.1710
            11  C1x C    29.0318  -15.8058
            12  C8y C    32.6314  -19.3473
            13  C8x C    31.4140  -20.0346
            14  C8x C    33.8372  -20.0579
            15  C8x C    31.4024  -21.4383
            16  C8x C    33.8198  -21.4559
            17  C8x C    32.5965  -22.1489
            18  X   Cl   39.0873  -18.1277
BOND        18
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    8  11 1
            11    9  11 1
            12   12  13 2
            13   12  14 1
            14   13  15 1
            15   14  16 2
            16   15  17 2
            17   16  17 1
            18    1  12 1 #Down

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