| Entry |
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| Symbol |
SRD5A1
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| Name |
3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC: 1.3.1.22]
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| Pathway |
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| Module |
| M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
| M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
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| Reaction |
| R02208 | 5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase |
| R02497 | dihydrotestosterone:NADP+ delta4-oxidoreductase |
| R08954 | 5alpha-dihydrodeoxycorticosterone:NADP+ delta4-oxidoreductase |
| R10242 | 5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase |
| R13215 | 5alpha-pregnan-17alpha-ol-3,20-dione:NADP+ Delta4-oxidoreductase |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
K12343 SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Enzymes [BR:ko01000]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
K12343 SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Andersson S, Russell DW |
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| Title |
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. |
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| Journal |
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| Sequence |
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| LinkDB |
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