KEGG   DRUG: Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
Entry
D04338            Mixture   Drug                                   
Name
Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride;
Sekicode (TN)
Component
Dihydrocodeine phosphate [DR:D01481], Ephedrine hydrochloride [DR:D01386], Ammonium chloride [DR:D01139]
Class
Respiratory system agent
 DG03282  Ephedrine-containing preparation
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Efficacy
Antitussive, Expectorant
Comment
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Drug groups [BR:br08330]
 Respiratory system agent
  DG03282  Ephedrine-containing preparation
   D04338  Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D04338  Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04338  Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D04338  Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
   DG03190  UGT2B7 substrate
    D04338  Dihydrocodeine phosphate, ephedrine hydrochloride and ammmonium chloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04338
Other DBs
PubChem: 17398060
LinkDB

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