| Entry |
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| Name |
Hydrocortisone hemisuccinate (USP) |
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| Formula |
C25H34O8. H2O
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| Exact mass |
480.2359
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| Mol weight |
480.5479
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
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| Remark |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D04467 Hydrocortisone hemisuccinate (USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D04467 Hydrocortisone hemisuccinate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D04467 Hydrocortisone hemisuccinate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D04467 Hydrocortisone hemisuccinate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04467
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C1y C 22.3791 -17.5210
2 C1y C 21.1944 -18.2037
3 C1z C 22.3791 -16.1553
4 C1x C 24.7485 -17.5210
5 C1y C 20.0097 -17.5210
6 C1x C 21.1827 -19.5753
7 C1z C 23.5697 -15.4667
8 C1x C 21.1944 -15.4667
9 C1a C 22.3733 -14.7838
10 C1x C 24.7485 -16.1553
11 C1z C 18.8192 -18.2037
12 C1y C 20.0097 -16.1553
13 C1x C 20.0097 -20.2580
14 C5a C 23.5755 -14.1011
15 O1a O 24.9120 -15.0932
16 C2y C 18.8192 -19.5753
17 C1x C 17.6402 -17.5210
18 C1a C 18.8075 -16.8381
19 O1a O 18.8192 -15.4667
20 C1b C 24.7544 -13.4182
21 O5a O 22.3850 -13.4182
22 C2x C 17.6402 -20.2580
23 C1x C 16.4498 -18.2037
24 O7a O 25.9449 -14.1068
25 C5x C 16.4498 -19.5753
26 O5x O 15.2651 -20.2580
27 C7a C 27.1456 -13.4077
28 C1b C 28.3515 -14.0989
29 C1b C 29.5573 -13.4008
30 C6a C 30.7632 -14.0918
31 O6a O 27.1409 -12.0115
32 O6a O 31.9702 -13.3898
33 O6a O 30.6972 -15.4695
34 O0 O 30.5200 -18.2000
BOND 36
1 3 8 1
2 3 9 1 #Up
3 4 10 1
4 5 11 1
5 5 12 1
6 6 13 1
7 7 14 1 #Up
8 7 15 1 #Down
9 11 16 1
10 11 17 1
11 11 18 1 #Up
12 12 19 1 #Up
13 14 20 1
14 14 21 2
15 16 22 2
16 17 23 1
17 20 24 1
18 22 25 1
19 25 26 2
20 7 10 1
21 8 12 1
22 13 16 1
23 23 25 1
24 24 27 1
25 1 2 1
26 27 28 1
27 1 3 1
28 28 29 1
29 1 4 1
30 29 30 1
31 2 5 1
32 27 31 2
33 2 6 1
34 3 7 1
35 30 32 1
36 30 33 2
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