KEGG   DRUG: Lisdexamfetamine dimesylateHelp
Entry
D04747                      Drug                                   

Name
Lisdexamfetamine dimesylate (USAN);
Lisdexamfetamine mesilate (JAN);
Vyvanse (TN);
Elvanse (TN)
Product
Formula
C15H25N3O. (CH4SO3)2
Exact mass
455.176
Mol weight
455.5898
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01970  Agents for ADHD
Remark
Therapeutic category: 1179
ATC code: N06BA12
Chemical structure group: DG00973
Product (DG00973): D04747<JP/US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Binge eating disorder [DS:H01703]
Comment
Treatment of attention deficit hyperactivity disorder (ADHD)
Active form of prodrug: Dextroamphetamine [DR:D03740]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA12 Lisdexamfetamine
      D04747  Lisdexamfetamine dimesylate (USAN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Lisdexamfetamine
    D04747  Lisdexamfetamine dimesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D04747  Lisdexamfetamine dimesylate (USAN); Lisdexamfetamine mesilate (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D04747  Lisdexamfetamine dimesylate (USAN) <JP/US>
    SLC6A3 (DAT1)
     D04747  Lisdexamfetamine dimesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04747
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04747
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04747
Prodrugs [br08324.html]
 DG00973
BRITE hierarchy
Other DBs
CAS: 608137-33-3
PubChem: 47206566
ChEMBL: CHEMBL1201178
LigandBox: D04747
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8x C     1.7500   -5.6700
            2   C8x C     1.7500   -7.0700
            3   C8x C     2.9624   -7.7700
            4   C8x C     4.1749   -7.0700
            5   C8y C     4.1749   -5.6700
            6   C8x C     2.9624   -4.9700
            7   C1b C     5.4060   -4.9590
            8   C1c C     6.6112   -5.6547
            9   N1b N     7.7935   -4.9719
            10  C1a C     6.6116   -7.0696
            11  C5a C     8.9875   -5.6612
            12  C1c C    10.1754   -4.9752
            13  O5a O     8.9877   -7.0697
            14  C1b C    11.3665   -5.6629
            15  C1b C    12.5559   -4.9761
            16  C1b C    13.7462   -5.6634
            17  C1b C    14.9361   -4.9763
            18  N1a N    16.1262   -5.6635
            19  N1a N    10.1755   -3.5702
            20  S4a S    22.2859   -5.9458
            21  C1a C    20.8827   -5.9458
            22  O1d O    23.6891   -5.9458
            23  O1d O    22.2859   -4.5426
            24  O1d O    22.2859   -7.3491
            25  S4a S    22.2859   -5.9458
            26  C1a C    20.8827   -5.9458
            27  O1d O    23.6891   -5.9458
            28  O1d O    22.2859   -4.5426
            29  O1d O    22.2859   -7.3491
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1 #Up
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   12  19 1 #Up
            20   20  21 1
            21   20  22 1
            22   20  23 2
            23   20  24 2
            24   25  26 1
            25   25  27 1
            26   25  28 2
            27   25  29 2
BRACKET     1    18.9700   -7.9100   18.9700   -3.5700
            1    25.2000   -3.5700   25.2000   -7.9100
            1  2
 ORIGINAL  1   20  21  22  23  24
 REPEAT    1   25  26  27  28  29

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