KEGG   DRUG: Lorajmine hydrochloride
Entry
D04774                      Drug                                   

Name
Lorajmine hydrochloride (USAN)
Formula
C22H27ClN2O3. HCl
Exact mass
438.1477
Mol weight
439.3753
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
ATC code: C01BA12
Efficacy
Antiarrhythmic
Comment
Ajmaline [DR:D00199] derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA12 Lorajmine
      D04774  Lorajmine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D04774  Lorajmine hydrochloride (USAN)
    SCN2A
     D04774  Lorajmine hydrochloride (USAN)
    SCN3A
     D04774  Lorajmine hydrochloride (USAN)
    SCN4A
     D04774  Lorajmine hydrochloride (USAN)
    SCN5A
     D04774  Lorajmine hydrochloride (USAN)
    SCN8A
     D04774  Lorajmine hydrochloride (USAN)
    SCN9A
     D04774  Lorajmine hydrochloride (USAN)
    SCN10A
     D04774  Lorajmine hydrochloride (USAN)
    SCN11A
     D04774  Lorajmine hydrochloride (USAN)
Other DBs
CAS: 40819-93-0
PubChem: 47206586
LigandBox: D04774
NIKKAJI: J244.499B
LinkDB
KCF data

ATOM        29
            1   X   Cl   33.7903  -40.0023
            2   C8x C    18.6200  -40.8100
            3   C8x C    18.6200  -42.2100
            4   C8x C    19.8100  -42.9100
            5   C8y C    21.0700  -42.2100
            6   C8y C    21.0700  -40.8100
            7   C8x C    19.8100  -40.1100
            8   N1y N    22.4000  -42.6300
            9   C1y C    23.1700  -41.5100
            10  C1z C    22.4000  -40.3900
            11  C1y C    24.5700  -41.3700
            12  N1y N    25.1300  -40.1100
            13  C1y C    24.3600  -38.9200
            14  C1x C    22.9600  -39.1300
            15  C1x C    25.5500  -42.3500
            16  C1y C    26.6700  -39.4800
            17  C1y C    27.8600  -40.3900
            18  C1y C    26.3200  -40.8800
            19  C1b C    29.2600  -40.6000
            20  C1y C    25.0600  -37.3800
            21  C1y C    22.4000  -37.3800
            22  O7a O    21.4200  -36.4000
            23  C7a C    20.2300  -35.7000
            24  C1b C    18.9700  -36.4000
            25  X   Cl   17.7800  -35.7000
            26  O6a O    20.2300  -34.3000
            27  C1a C    22.4000  -44.0300
            28  C1a C    29.7724  -41.9029
            29  O1a O    27.6599  -38.4901
BOND        33
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1 #Down
            16   11  15 1
            17   12  16 1
            18   16  17 1
            19   17  18 1
            20   18  15 1
            21   17  19 1 #Up
            22   13  20 1 #Up
            23   18  20 1 #Up
            24   20  21 1
            25   21  10 1
            26   21  22 1 #Down
            27   22  23 1
            28   23  24 1
            29   24  25 1
            30   23  26 2
            31    8  27 1
            32   19  28 1
            33   16  29 1 #Down

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