| Entry |
|
|---|
| Name |
Lorajmine hydrochloride (USAN) |
|---|
| Formula |
C22H27ClN2O3. HCl
|
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| Exact mass |
438.1477
|
|---|
| Mol weight |
439.37
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
|
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| Remark |
|
|---|
| Efficacy |
Antiarrhythmic |
|---|
| Comment |
Ajmaline [DR: D00199] derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA12 Lorajmine
D04774 Lorajmine hydrochloride (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
D04774 Lorajmine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D04774 Lorajmine hydrochloride (USAN)
SCN2A
D04774 Lorajmine hydrochloride (USAN)
SCN3A
D04774 Lorajmine hydrochloride (USAN)
SCN4A
D04774 Lorajmine hydrochloride (USAN)
SCN5A
D04774 Lorajmine hydrochloride (USAN)
SCN8A
D04774 Lorajmine hydrochloride (USAN)
SCN9A
D04774 Lorajmine hydrochloride (USAN)
SCN10A
D04774 Lorajmine hydrochloride (USAN)
SCN11A
D04774 Lorajmine hydrochloride (USAN)
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 X Cl 33.7903 -40.0023
2 C8x C 18.6200 -40.8100
3 C8x C 18.6200 -42.2100
4 C8x C 19.8100 -42.9100
5 C8y C 21.0700 -42.2100
6 C8y C 21.0700 -40.8100
7 C8x C 19.8100 -40.1100
8 N1y N 22.4000 -42.6300
9 C1y C 23.1700 -41.5100
10 C1z C 22.4000 -40.3900
11 C1y C 24.5700 -41.3700
12 N1y N 25.1300 -40.1100
13 C1y C 24.3600 -38.9200
14 C1x C 22.9600 -39.1300
15 C1x C 25.5500 -42.3500
16 C1y C 26.6700 -39.4800
17 C1y C 27.8600 -40.3900
18 C1y C 26.3200 -40.8800
19 C1b C 29.2600 -40.6000
20 C1y C 25.0600 -37.3800
21 C1y C 22.4000 -37.3800
22 O7a O 21.4200 -36.4000
23 C7a C 20.2300 -35.7000
24 C1b C 18.9700 -36.4000
25 X Cl 17.7800 -35.7000
26 O6a O 20.2300 -34.3000
27 C1a C 22.4000 -44.0300
28 C1a C 29.7724 -41.9029
29 O1a O 27.6599 -38.4901
BOND 33
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 5 8 1
8 8 9 1
9 9 10 1
10 6 10 1
11 9 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 10 14 1 #Down
16 11 15 1
17 12 16 1
18 16 17 1
19 17 18 1
20 18 15 1
21 17 19 1 #Up
22 13 20 1 #Up
23 18 20 1 #Up
24 20 21 1
25 21 10 1
26 21 22 1 #Down
27 22 23 1
28 23 24 1
29 24 25 1
30 23 26 2
31 8 27 1
32 19 28 1
33 16 29 1 #Down
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