KEGG   DRUG: PractololHelp
Entry
D05587                      Drug                                   

Name
Practolol (USAN)
Formula
C14H22N2O3
Exact mass
266.163
Mol weight
266.3361
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Remark
Same as: C11696
ATC code: C07AB01
Efficacy
Antiarrhythmic, beta1-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB01 Practolol
      D05587  Practolol (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB1
     D05587  Practolol (USAN)
BRITE hierarchy
Other DBs
CAS: 6673-35-4
PubChem: 47207250
ChEBI: 258351
ChEMBL: CHEMBL6995
DrugBank: DB01297
LigandBox: D05587
NIKKAJI: J8.428J
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    16.1700  -14.8400
            2   C8x C    14.9800  -15.5400
            3   C8x C    17.4300  -15.5400
            4   O2a O    16.1700  -13.4400
            5   C8x C    14.9800  -16.9400
            6   C8x C    17.4300  -16.9400
            7   C1b C    17.3600  -12.7400
            8   C8y C    16.2400  -17.6400
            9   C1c C    18.6200  -13.3700
            10  N1b N    16.2400  -19.0400
            11  C1b C    19.8100  -12.6700
            12  O1a O    18.6200  -14.7700
            13  C5a C    15.0500  -19.7400
            14  N1b N    21.0000  -13.3700
            15  C1a C    13.8600  -19.0400
            16  O5a O    15.0500  -21.1400
            17  C1c C    22.1900  -12.6700
            18  C1a C    23.4500  -13.3000
            19  C1a C    22.1900  -11.2700
BOND        19
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   14  17 1
            17   17  18 1
            18   17  19 1
            19    6   8 2

» Japanese version   » Back

DBGET integrated database retrieval system