KEGG   DRUG: Practolol
Entry
D05587                      Drug                                   
Name
Practolol (USAN)
Formula
C14H22N2O3
Exact mass
266.163
Mol weight
266.3361
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
   DG01461  beta1-Adrenergic receptor antagonist
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
Remark
Same as: C11696
ATC code: C07AB01
Efficacy
Antiarrhythmic, beta1-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Structure map
map07037  Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB01 Practolol
      D05587  Practolol (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG01461  beta1-Adrenergic receptor antagonist
     D05587  Practolol
  DG01653  Antiarrhythmics
   DG01806  Class II antiarrhythmic agent
    D05587  Practolol
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB1
     D05587  Practolol (USAN)
Other DBs
CAS: 6673-35-4
PubChem: 47207250
ChEBI: 258351
LigandBox: D05587
NIKKAJI: J8.428J
LinkDB
KCF data

ATOM        19
            1   C8y C    16.1700  -14.8400
            2   C8x C    14.9800  -15.5400
            3   C8x C    17.4300  -15.5400
            4   O2a O    16.1700  -13.4400
            5   C8x C    14.9800  -16.9400
            6   C8x C    17.4300  -16.9400
            7   C1b C    17.3600  -12.7400
            8   C8y C    16.2400  -17.6400
            9   C1c C    18.6200  -13.3700
            10  N1b N    16.2400  -19.0400
            11  C1b C    19.8100  -12.6700
            12  O1a O    18.6200  -14.7700
            13  C5a C    15.0500  -19.7400
            14  N1b N    21.0000  -13.3700
            15  C1a C    13.8600  -19.0400
            16  O5a O    15.0500  -21.1400
            17  C1c C    22.1900  -12.6700
            18  C1a C    23.4500  -13.3000
            19  C1a C    22.1900  -11.2700
BOND        19
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   14  17 1
            17   17  18 1
            18   17  19 1
            19    6   8 2

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