KEGG   DRUG: Stiripentol
Entry
D05928                      Drug                                   

Name
Stiripentol (JAN/USAN/INN);
Diacomit (TN)
Product
Formula
C14H18O3
Exact mass
234.1256
Mol weight
234.2909
Structure
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 1139
ATC code: N03AX17
Product: D05928<JP/US>
Efficacy
Anticonvulsant, Antiepileptic
  Disease
Dravet syndrome [DS:H01818]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557], CYP2C9 [HSA:1559]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX17 Stiripentol
      D05928  Stiripentol (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Multiple MoA
    Stiripentol
     D05928  Stiripentol (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D05928  Stiripentol (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05928
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05928
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05928
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05928
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05928
Other DBs
CAS: 137767-55-6 49763-96-4
PubChem: 47207586
ChEMBL: CHEMBL1983350
LigandBox: D05928
NIKKAJI: J10.374H
LinkDB
KCF data

ATOM        17
            1   C8y C    16.0300  -17.9200
            2   C8y C    16.0300  -19.3200
            3   C8x C    17.2424  -20.0200
            4   C8x C    18.4549  -19.3200
            5   C8y C    18.4549  -17.9200
            6   C8x C    17.2424  -17.2200
            7   O2x O    14.6985  -17.4874
            8   C1x C    13.8756  -18.6200
            9   O2x O    14.6985  -19.7526
            10  C2b C    19.6860  -17.2090
            11  C2b C    20.8912  -17.9047
            12  C1c C    22.0735  -17.2219
            13  C1d C    23.2675  -17.9112
            14  O1a O    22.0735  -15.8202
            15  C1a C    24.4799  -18.6112
            16  C1a C    22.5571  -19.1422
            17  C1a C    23.9565  -16.7172
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    2   9 1
            11    5  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 1
            15   12  14 1
            16   13  15 1
            17   13  16 1
            18   13  17 1

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