| Entry |
|
|---|
| Name |
Tapentadol (USAN/INN) |
|---|
| Formula |
C14H23NO
|
|---|
| Exact mass |
221.1780
|
|---|
| Mol weight |
221.34
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG00826): | D10199<JP/US> |
|
|---|
| Efficacy |
Analgesic, Opioid receptor agonist, Noradrenaline reuptake inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AX Other opioids
N02AX06 Tapentadol
D06007 Tapentadol (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00826 Tapentadol
D06007 Tapentadol
Analgesic
DG01984 Opioid analgesics
DG00826 Tapentadol
D06007 Tapentadol
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00826 Tapentadol
D06007 Tapentadol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D06007 Tapentadol (USAN/INN)
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D06007 Tapentadol (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06007
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Cabinet Order Article 1 (163 substances)
D06007
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00826 Tapentadol
Analgesic
DG01984 Opioid analgesics
DG00826 Tapentadol
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00826 Tapentadol
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 16
1 C8y C 16.4500 -15.8900
2 C8x C 16.4500 -17.2900
3 C8x C 17.6624 -17.9900
4 C8x C 18.8749 -17.2900
5 C8y C 18.8749 -15.8900
6 C8x C 17.6624 -15.1900
7 O1a O 15.2376 -15.1900
8 C1c C 20.1060 -15.1790
9 C1c C 21.3112 -15.8747
10 C1b C 20.1057 -13.7901
11 C1b C 22.4935 -15.1919
12 C1a C 21.3062 -13.0966
13 N1c N 23.6875 -15.8812
14 C1a C 21.3116 -17.2896
15 C1a C 24.8754 -15.1952
16 C1a C 23.6877 -17.2897
BOND 16
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 5 8 1
9 8 9 1
10 8 10 1 #Down
11 9 11 1
12 10 12 1
13 11 13 1
14 9 14 1 #Down
15 13 15 1
16 13 16 1
|
|---|
