KEGG   DRUG: TapentadolHelp
Entry
D06007                      Drug                                   

Name
Tapentadol (USAN/INN)
Formula
C14H23NO
Exact mass
221.178
Mol weight
221.3385
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
ATC code: N02AX06
Chemical structure group: DG00826
Product (DG00826): D10199<JP/US>
Efficacy
Analgesic, Opioid receptor agonist, Noradrenaline reuptake inhibitor
Target
OPRM1 [HSA:4988] [KO:K04215]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AX Other opioids
     N02AX06 Tapentadol
      D06007  Tapentadol (USAN/INN)
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Short-acting
   Tapentadol
    D06007  Tapentadol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D06007  Tapentadol (USAN/INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D06007  Tapentadol (USAN/INN)
Drug classes of therapeutic agents [br08360.html]
 Anesthetics, analgesics and anti-inflammatory drugs
  D06007
BRITE hierarchy
Other DBs
CAS: 175591-23-8
PubChem: 47207665
ChEMBL: CHEMBL1201776
LigandBox: D06007
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8y C    16.4500  -15.8900
            2   C8x C    16.4500  -17.2900
            3   C8x C    17.6624  -17.9900
            4   C8x C    18.8749  -17.2900
            5   C8y C    18.8749  -15.8900
            6   C8x C    17.6624  -15.1900
            7   O1a O    15.2376  -15.1900
            8   C1c C    20.1060  -15.1790
            9   C1c C    21.3112  -15.8747
            10  C1b C    20.1057  -13.7901
            11  C1b C    22.4935  -15.1919
            12  C1a C    21.3062  -13.0966
            13  N1c N    23.6875  -15.8812
            14  C1a C    21.3116  -17.2896
            15  C1a C    24.8754  -15.1952
            16  C1a C    23.6877  -17.2897
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1 #Down
            11    9  11 1
            12   10  12 1
            13   11  13 1
            14    9  14 1 #Down
            15   13  15 1
            16   13  16 1

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