KEGG   DRUG: Hydrocortisone aceponateHelp
Entry
D06876                      Drug                                   

Name
Hydrocortisone aceponate (INN);
Efficort (TN)
Formula
C26H36O7
Exact mass
460.2461
Mol weight
460.5598
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Enzyme substrate
 DG01633  CYP3A substrate
Remark
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AC16 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<JP/US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
    D07AC Corticosteroids, potent (group III)
     D07AC16 Hydrocortisone aceponate
      D06876  Hydrocortisone aceponate (INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D06876  Hydrocortisone aceponate (INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D06876  Hydrocortisone aceponate (INN)
  Hydrocortisone
   D06876  Hydrocortisone aceponate (INN)
  Hydrocortisone
   D06876  Hydrocortisone aceponate (INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D06876  Hydrocortisone aceponate (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D06876  Hydrocortisone aceponate (INN)
Animal drugs in Japan [BR:br08331]
 95  Agents for external use
  953  Analgesics, anti-itchings, astringents and antiinflammatory agents
   9537  Hormone preparations for external use
    D06876  Hydrocortisone aceponate
BRITE hierarchy
Other DBs
CAS: 74050-20-7
PubChem: 49661776
ChEMBL: CHEMBL2106309
LigandBox: D06876
LinkDB All DBs
KCF data Show

ATOM        33
            1   C1y C    28.7000  -19.1100
            2   C1y C    27.5100  -19.8100
            3   C1z C    28.7000  -17.7800
            4   C1x C    31.0100  -19.1100
            5   C1y C    26.3200  -19.1100
            6   C1x C    27.5100  -21.1400
            7   C1z C    29.8900  -17.0800
            8   C1x C    27.5100  -17.0800
            9   C1a C    28.7000  -16.3800
            10  C1x C    31.0100  -17.7800
            11  C1z C    25.1300  -19.8100
            12  C1y C    26.3200  -17.7800
            13  C1x C    26.3200  -21.8400
            14  C5a C    29.8900  -15.6800
            15  C2y C    25.1300  -21.1400
            16  C1x C    23.9400  -19.1100
            17  C1a C    25.1300  -18.4100
            18  O1a O    25.1300  -17.0800
            19  C1b C    31.0800  -14.9800
            20  O5a O    28.7000  -14.9800
            21  C2x C    23.9400  -21.8400
            22  C1x C    22.7500  -19.8100
            23  C5x C    22.7500  -21.1400
            24  O5x O    21.5600  -21.8400
            25  O7a O    31.2200  -16.7300
            26  C7a C    32.3477  -17.5596
            27  O6a O    32.3452  -18.9700
            28  C1b C    33.5872  -16.9341
            29  C1a C    34.7700  -17.7088
            30  O7a O    31.0686  -13.5800
            31  C7a C    32.2837  -12.8652
            32  C1a C    33.4977  -13.5529
            33  O6a O    32.2723  -11.4800
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   21  23 1
            23   23  24 2
            24    7  10 1
            25    8  12 1
            26   13  15 1
            27   22  23 1
            28    7  25 1 #Down
            29   25  26 1
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   19  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 2

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