| Entry |
|
|---|
| Name |
Eletriptan hydrobromide (JAN/USAN);
Relpax (TN) |
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| Product |
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| Generic |
ELETRIPTAN HBR (Direct_Rx), ELETRIPTAN HBR (Direct_Rx), ELETRIPTAN HYDROBROMIDE (Advanced Rx of Tennessee), ELETRIPTAN HYDROBROMIDE (Ajanta Pharma USA), ELETRIPTAN HYDROBROMIDE (Aurobindo Pharma Limited), ELETRIPTAN HYDROBROMIDE (Bryant Ranch Prepack), ELETRIPTAN HYDROBROMIDE (Mylan Pharmaceuticals), ELETRIPTAN HYDROBROMIDE (Quality Care Products), ELETRIPTAN HYDROBROMIDE (Teva Pharmaceuticals USA), ELETRIPTAN HYDROBROMIDE (Zydus Lifesciences Limited), ELETRIPTAN HYDROBROMIDE (Zydus Pharmaceuticals USA) |
|---|
| Formula |
C22H26N2O2S. HBr
|
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| Exact mass |
462.0977
|
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| Mol weight |
463.43
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Analgesic
DG01484 5-HT1B-receptor agonist
DG01485 5-HT1D-receptor agonist
DG01518 5-HT1B/1D-receptor agonist
DG01943 Triptan
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2160 |
| Product (DG00840): | D01973<JP/US> |
|
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| Efficacy |
Antimigraine, Vasoconstrictor, Serotonin receptor agonist |
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| Comment |
Sumatriptan derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CC Selective serotonin (5HT1) agonists
N02CC06 Eletriptan
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
Serotonin (5-HT) Receptor Agonists
Eletriptan
D01973 Eletriptan hydrobromide (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
216 Vasoconstrictors
2160 Vasoconstrictors
D01973 Eletriptan hydrobromide (JAN/USAN)
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01485 5-HT1D-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01518 5-HT1B/1D-receptor agonist
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
DG01943 Triptan
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00840 Eletriptan
D01973 Eletriptan hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
HTR1D
D01973 Eletriptan hydrobromide (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01973
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01973
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01973
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01973
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00840 Eletriptan
DG01485 5-HT1D-receptor agonist
DG00840 Eletriptan
DG01518 5-HT1B/1D-receptor agonist
DG00840 Eletriptan
DG01943 Triptan
DG00840 Eletriptan
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00840 Eletriptan
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 28
1 X Br 24.7100 -15.8900
2 C1y C 22.4224 -12.6000
3 N1y N 22.4224 -11.2000
4 C1a C 21.1933 -10.4902
5 C1x C 23.7539 -13.0326
6 C1x C 24.5768 -11.9000
7 C1x C 23.7539 -10.7674
8 C8x C 17.4300 -16.5200
9 C8y C 17.4300 -15.1200
10 C8x C 18.6900 -14.4200
11 C8y C 19.8800 -15.1200
12 C8y C 19.8800 -16.5200
13 C8x C 18.6900 -17.2200
14 C8y C 21.2100 -14.7000
15 C8x C 22.0500 -15.8200
16 N4x N 21.2100 -16.9400
17 C1b C 16.2400 -14.4200
18 C1b C 15.0500 -15.1200
19 S4a S 13.8600 -14.4200
20 C8y C 12.6000 -15.1200
21 C8x C 12.6000 -16.5200
22 C8x C 11.4100 -17.2200
23 C8x C 10.2200 -16.5200
24 C8x C 10.2200 -15.1200
25 C8x C 11.4100 -14.4200
26 C1b C 21.2100 -13.3000
27 O3c O 14.8499 -13.4301
28 O3c O 12.8701 -13.4301
BOND 30
1 2 3 1
2 3 4 1
3 2 5 1
4 5 6 1
5 6 7 1
6 3 7 1
7 8 9 2
8 9 10 1
9 10 11 2
10 11 12 1
11 12 13 2
12 8 13 1
13 11 14 1
14 14 15 2
15 15 16 1
16 12 16 1
17 9 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 23 24 1
25 24 25 2
26 20 25 1
27 14 26 1
28 2 26 1 #Down
29 19 27 2
30 19 28 2
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