| Entry |
|
|---|
| Name |
Phenoxybenzamine (INN) |
|---|
| Formula |
C18H22ClNO
|
|---|
| Exact mass |
303.1390
|
|---|
| Mol weight |
303.82
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
|
|---|
| Remark |
| Product (DG00285): | D00507<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator (peripheric), alpha-Adrenergic receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C04 PERIPHERAL VASODILATORS
C04A PERIPHERAL VASODILATORS
C04AX Other peripheral vasodilators
C04AX02 Phenoxybenzamine
D08358 Phenoxybenzamine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG00285 Phenoxybenzamine
D08358 Phenoxybenzamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08358 Phenoxybenzamine (INN)
ADRA2
D08358 Phenoxybenzamine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG00285 Phenoxybenzamine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 21
1 C8x C 19.7400 -19.1100
2 C8x C 19.7400 -20.5100
3 C8x C 20.9524 -21.2100
4 C8y C 22.1649 -20.5100
5 C8x C 22.1649 -19.1100
6 C8x C 20.9524 -18.4100
7 C1b C 23.3960 -21.2210
8 N1c N 24.6012 -20.5253
9 C1c C 25.7835 -21.2081
10 C1b C 26.9775 -20.5188
11 C1a C 25.7835 -22.6098
12 C1b C 24.6016 -19.1104
13 C1b C 25.7905 -18.4241
14 X Cl 25.7910 -17.0103
15 O2a O 28.1654 -21.2048
16 C8y C 29.3565 -20.5171
17 C8x C 30.5459 -21.2039
18 C8x C 31.7584 -20.5040
19 C8x C 31.7585 -19.1040
20 C8x C 30.5691 -18.4172
21 C8x C 29.3566 -19.1171
BOND 22
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 9 11 1
12 8 12 1
13 12 13 1
14 13 14 1
15 10 15 1
16 15 16 1
17 16 17 2
18 17 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 16 21 1
|
|---|
