| Entry |
|
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| Name |
Quinidine phenylethylbarbiturate;
Quinidine 5-ethyl 5-phenyl barbiturate;
Natisedine (TN) |
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| Formula |
C20H24N2O2. C12H12N2O3
|
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| Exact mass |
556.2686
|
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| Mol weight |
556.65
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00192): | D00642<US> D02272<JP/US> |
|
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| Efficacy |
Antiarrhythmic, Antimalarial, Sodium channel blocker |
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA01 Quinidine
D08459 Quinidine phenylethylbarbiturate
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
D08459 Quinidine phenylethylbarbiturate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00192 Quinidine
D08459 Quinidine phenylethylbarbiturate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D08459 Quinidine phenylethylbarbiturate
SCN2A
D08459 Quinidine phenylethylbarbiturate
SCN3A
D08459 Quinidine phenylethylbarbiturate
SCN4A
D08459 Quinidine phenylethylbarbiturate
SCN5A
D08459 Quinidine phenylethylbarbiturate
SCN8A
D08459 Quinidine phenylethylbarbiturate
SCN9A
D08459 Quinidine phenylethylbarbiturate
SCN10A
D08459 Quinidine phenylethylbarbiturate
SCN11A
D08459 Quinidine phenylethylbarbiturate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08459
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00192 Quinidine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 C1z C 27.8054 -23.3458
2 C8y C 28.9932 -22.6471
3 C5x C 26.5478 -22.6471
4 C5x C 27.8054 -24.7432
5 C1b C 28.9932 -24.0445
6 C8x C 30.1810 -23.2759
7 C8x C 28.9932 -21.2497
8 N1x N 25.3600 -23.3458
9 O5x O 26.5478 -21.2497
10 N1x N 26.5478 -25.4419
11 O5x O 28.9932 -25.4419
12 C1a C 30.3906 -24.0445
13 C8x C 31.4386 -22.5772
14 C8x C 30.1810 -20.4811
15 C5x C 25.3600 -24.7432
16 C8x C 31.4386 -21.1798
17 O5x O 24.1722 -25.4419
18 C8y C 17.6045 -25.9310
19 C8y C 18.8621 -25.2323
20 C8y C 17.6045 -27.3283
21 C8x C 16.4167 -25.2323
22 C1c C 18.8621 -23.8349
23 C8x C 20.0499 -25.9310
24 C8x C 16.4167 -28.0270
25 N5x N 18.7923 -28.0270
26 C8y C 15.1590 -25.9310
27 C1y C 20.0499 -23.1362
28 O1a O 17.6045 -23.1362
29 C8x C 20.0499 -27.3283
30 C8x C 15.1590 -27.3283
31 O2a O 13.9713 -25.2323
32 N1y N 21.5172 -22.2279
33 C1x C 19.3512 -22.0881
34 C1a C 13.9713 -23.8349
35 C1x C 21.5172 -20.9702
36 C1x C 22.9844 -23.0663
37 C1y C 20.7486 -21.2497
38 C1y C 20.7486 -20.2715
39 C1x C 22.2857 -21.9484
40 C2b C 20.1896 -18.9440
41 C2a C 21.0979 -17.8261
BOND 45
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 2
9 4 10 1
10 4 11 2
11 5 12 1
12 6 13 1
13 7 14 2
14 8 15 1
15 13 16 2
16 15 17 2
17 10 15 1
18 14 16 1
19 18 19 1
20 18 20 1
21 18 21 2
22 19 22 1
23 19 23 2
24 20 24 2
25 20 25 1
26 21 26 1
27 22 27 1
28 22 28 1 #Down
29 23 29 1
30 24 30 1
31 26 31 1
32 27 32 1
33 27 33 1
34 31 34 1
35 32 35 1
36 32 36 1
37 33 37 1
38 35 38 1
39 36 39 1
40 38 40 1 #Up
41 40 41 2
42 25 29 2
43 26 30 2
44 37 38 1
45 37 39 1
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