KEGG   DRUG: TizanidineHelp
Entry
D08611                      Drug                                   

Name
Tizanidine (INN);
Sirdalud (TN)
Product
  Generic
Formula
C9H8ClN5S
Exact mass
253.0189
Mol weight
253.7113
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Other
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
 DG01974  Centrally acting muscle relaxant
Enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Same as: C07452
ATC code: M03BX02
Chemical structure group: DG00773
Product (DG00773): D08611<US> D00776<JP/US>
Efficacy
Muscle relaxant, alpha2-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
    M03BX Other centrally acting agents
     M03BX02 Tizanidine
      D08611  Tizanidine (INN) <US>
USP drug classification [BR:br08302]
 Antispasticity Agents
  Tizanidine
   D08611  Tizanidine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D08611  Tizanidine (INN) <US>
BRITE hierarchy
Other DBs
CAS: 51322-75-9
PubChem: 96025295
ChEBI: 63629
ChEMBL: CHEMBL1079
DrugBank: DB00697
LigandBox: D08611
NIKKAJI: J11.180E
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8y C    23.1000  -18.6200
            2   C8y C    23.1000  -17.2200
            3   C8y C    21.8400  -19.3900
            4   N5x N    24.1500  -19.6000
            5   N1b N    24.2900  -16.5200
            6   C8y C    21.8400  -16.5200
            7   C8x C    20.6500  -18.6200
            8   N5x N    22.1900  -20.7200
            9   S2x S    23.5900  -20.7900
            10  C2y C    25.4800  -17.2900
            11  C8x C    20.6500  -17.2200
            12  X   Cl   21.8400  -15.1200
            13  N1x N    26.8100  -16.8000
            14  N2x N    25.4800  -18.6900
            15  C1x C    27.6500  -17.9200
            16  C1x C    26.8800  -19.0400
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   13  15 1
            15   14  16 1
            16    7  11 2
            17    8   9 1
            18   15  16 1

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