| Entry |
|
|---|
| Name |
Choline fenofibrate (USAN/INN);
Trilipix (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C17H14ClO4. C5H14NO
|
|---|
| Exact mass |
421.1656
|
|---|
| Mol weight |
421.91
|
|---|
| Structure |
|
|---|
| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG01548): | D00565<JP/US> D08890<US> |
|
|---|
| Efficacy |
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist |
|---|
| Disease |
Hypertriglyceridemia [DS: H01637] Primary hypercholesterolemia or mixed dyslipidemia [DS: H01635] |
|---|
| Comment |
Clofibrate derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04920 | Adipocytokine signaling pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AB Fibrates
C10AB11 Choline fenofibrate
D08890 Choline fenofibrate (USAN/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, Fibric Acid Derivatives
Choline Fenofibrate
D08890 Choline fenofibrate (USAN/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
DG01548 Fenofibrate
D08890 Choline fenofibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01548 Fenofibrate
D08890 Choline fenofibrate
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D08890 Choline fenofibrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C1 (PPARA)
D08890 Choline fenofibrate (USAN/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08890
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
DG01548 Fenofibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01548 Fenofibrate
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 29
1 C8y C 18.3598 -16.7433
2 C5a C 17.1689 -17.4439
3 C8x C 19.6208 -17.4439
4 C8x C 18.3598 -15.3422
5 C8y C 15.9779 -16.7433
6 O5a O 17.1689 -18.8450
7 C8x C 20.8118 -16.7433
8 C8x C 19.6208 -14.6417
9 C8x C 14.7169 -17.4439
10 C8x C 15.9779 -15.3422
11 C8y C 20.8118 -15.3422
12 C8x C 13.5260 -16.7433
13 C8x C 14.7169 -14.6417
14 O2a O 22.0027 -14.6417
15 C8y C 13.5260 -15.3422
16 C1d C 23.2637 -15.3422
17 X Cl 12.3350 -14.6417
18 C6a C 24.4547 -14.6417
19 O6a O 25.6456 -15.3422 #-
20 O6a O 24.4547 -13.2406
21 C1a C 22.5632 -16.5332
22 C1a C 23.9643 -16.5332
23 C1a C 29.8900 -16.7300
24 N1d N 31.0800 -16.0300 #+
25 C1b C 32.3400 -16.7300
26 C1b C 33.5300 -16.0300
27 O1a O 34.7200 -16.7300
28 C1a C 31.0800 -14.6300
29 C1a C 31.0800 -17.4300
BOND 29
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 2
8 5 9 2
9 5 10 1
10 7 11 2
11 9 12 1
12 10 13 2
13 11 14 1
14 12 15 2
15 14 16 1
16 15 17 1
17 16 18 1
18 18 19 1
19 18 20 2
20 8 11 1
21 13 15 1
22 16 21 1
23 16 22 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 24 28 1
29 24 29 1
|
|---|
