KEGG   DRUG: Norepinephrine hydrochloride
Entry
D09794                      Drug                                   

Name
Norepinephrine hydrochloride (JAN);
(+/-)-Noradrenaline hydrochloride
Formula
C8H11NO3. HCl
Exact mass
205.0506
Mol weight
205.6388
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D09794  Norepinephrine hydrochloride (JAN)
    ADRA2
     D09794  Norepinephrine hydrochloride (JAN)
    ADRB
     D09794  Norepinephrine hydrochloride (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09794
Other DBs
CAS: 55-27-6
PubChem: 124490534
ChEMBL: CHEMBL1734806
LigandBox: D09794
LinkDB
KCF data

ATOM        13
            1   C8y C    31.0800  -22.1900
            2   C8x C    31.0800  -23.5900
            3   C8x C    29.8200  -21.4900
            4   C1c C    32.2700  -21.4900
            5   C8x C    29.8200  -24.2900
            6   C8y C    28.6300  -22.1900
            7   C1b C    33.4600  -22.1900
            8   O1a O    32.2700  -20.0900
            9   C8y C    28.6300  -23.5900
            10  N1a N    34.6500  -21.4900
            11  O1a O    27.4400  -24.2900
            12  O1a O    27.4400  -21.4900
            13  X   Cl   33.8800  -24.2900
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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