| Entry |
|
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| Name |
Quizartinib (USAN/INN) |
|---|
| Formula |
C29H32N6O4S
|
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| Exact mass |
560.2206
|
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| Mol weight |
560.67
|
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| Structure |
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| Simcomp |
|
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| Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01364): | D09956<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
|---|
| Target |
|
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| Pathway |
|
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| Metabolism |
|
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| Interaction |
|
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| Structure map |
| map07045 | Antineoplastics - protein kinase inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EX Other protein kinase inhibitors
L01EX11 Quizartinib
D09955 Quizartinib (USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG01364 Quizartinib
D09955 Quizartinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01364 Quizartinib
D09955 Quizartinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
FLT3 (CD135)
D09955 Quizartinib (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09955
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG01364 Quizartinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01364 Quizartinib
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 40
1 C1x C 36.8374 -17.7901
2 O2x O 36.8374 -19.1909
3 C1x C 35.6467 -19.8912
4 C1x C 34.3861 -19.1909
5 N1y N 34.3861 -17.7901
6 C1x C 35.6467 -17.0898
7 C1b C 33.1954 -17.0898
8 C1b C 32.0048 -17.7901
9 O2a O 30.8142 -17.0898
10 C8y C 29.6235 -17.7901
11 C8x C 29.6235 -19.1909
12 C8x C 28.3628 -19.8912
13 C8y C 27.1722 -19.1909
14 C8y C 27.1722 -17.7901
15 C8x C 28.3628 -17.0898
16 N4y N 25.8415 -19.6111
17 C8y C 25.0011 -18.4905
18 S2x S 25.8415 -17.3699
19 C8x C 25.0011 -20.7317
20 C8y C 23.6704 -20.3115
21 N5x N 23.6704 -18.9107
22 C8y C 22.4797 -21.0118
23 C8x C 22.4797 -22.4126
24 C8x C 21.2891 -23.1130
25 C8y C 20.0284 -22.4126
26 C8x C 20.0284 -21.0118
27 C8x C 21.2891 -20.3115
28 N1b N 18.8378 -23.1130
29 C5a C 17.6472 -22.4126
30 N1b N 16.4565 -23.1130
31 O5a O 17.6472 -21.0118
32 C8y C 15.2659 -22.4126
33 N5x N 13.8651 -22.4126
34 O2x O 13.3749 -21.0819
35 C8y C 14.5655 -20.2414
36 C8x C 15.6861 -21.0819
37 C1d C 14.5655 -18.8407
38 C1a C 14.5655 -17.4399
39 C1a C 15.9655 -18.8407
40 C1a C 13.1655 -18.8407
BOND 45
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 10 15 2
17 13 16 1
18 16 17 1
19 17 18 1
20 14 18 1
21 16 19 1
22 19 20 2
23 20 21 1
24 17 21 2
25 20 22 1
26 22 23 1
27 23 24 2
28 24 25 1
29 25 26 2
30 26 27 1
31 22 27 2
32 25 28 1
33 28 29 1
34 29 30 1
35 29 31 2
36 30 32 1
37 32 33 2
38 33 34 1
39 34 35 1
40 35 36 2
41 32 36 1
42 35 37 1
43 37 38 1
44 37 39 1
45 37 40 1
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