Homo sapiens (human): 2322
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Entry
2322 CDS
T01001
Symbol
FLT3, CD135, FLK-2, FLK2, STK1
Name
(RefSeq) fms related receptor tyrosine kinase 3
KO
K05092
fms-related tyrosine kinase 3 [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04640
Hematopoietic cell lineage
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05221
Acute myeloid leukemia
hsa05230
Central carbon metabolism in cancer
Network
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06219
JAK-STAT signaling (cancer)
nt06240
Transcription (cancer)
nt06262
Pancreatic cancer
nt06275
Acute myeloid leukemia
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N00004
Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00031
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00054
Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway
N00119
MLL-AF4 fusion to transcriptional activation
N00217
FLT3LG-FLT3-RAS-ERK signaling pathway
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00219
FLT3LG-FLT3-STAT5 signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01599
Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00003
Acute myeloid leukemia
H02411
Chronic myelomonocytic leukemia
H02412
Atypical chronic myeloid leukemia
Drug target
Crenolanib (
DG01361
):
D10102
D10103
Dovitinib lactate:
D08907
Emirodatamab:
D12641
Gilteritinib (
DG01948
):
D10709
D10800
<JP/US>
Lestaurtinib:
D04696
Midostaurin:
D05029
<US>
Pacritinib:
D11768
<US>
Pexidartinib (
DG02960
):
D11270
D11271
<US>
Quizartinib (
DG01364
):
D09955
D09956
<JP/US>
Semaxanib:
D05819
Sorafenib (
DG00713
):
D06272
<JP/US>
D08524
Sunitinib (
DG00712
):
D06402
<JP/US>
D08552
Tandutinib:
D06005
Tozasertib (
DG01365
):
D08279
D08344
Tuspetinib:
D12476
Zotiraciclib (
DG03058
):
D11599
D11600
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2322 (FLT3)
04151 PI3K-Akt signaling pathway
2322 (FLT3)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
2322 (FLT3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2322 (FLT3)
05202 Transcriptional misregulation in cancer
2322 (FLT3)
05230 Central carbon metabolism in cancer
2322 (FLT3)
09162 Cancer: specific types
05221 Acute myeloid leukemia
2322 (FLT3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2322 (FLT3)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
2322 (FLT3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
2322 (FLT3)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
PDGFR family [OT]
2322 (FLT3)
CD molecules [BR:
hsa04090
]
Proteins
2322 (FLT3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
ig
I-set
Ig_3
Ig_2
Haspin_kinase
APH
Motif
Other DBs
NCBI-GeneID:
2322
NCBI-ProteinID:
NP_004110
OMIM:
136351
HGNC:
3765
Ensembl:
ENSG00000122025
UniProt:
P36888
Structure
PDB
PDBj
LinkDB
All DBs
Position
13:complement(28003274..28100576)
Genome browser
AA seq
993 aa
AA seq
DB search
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
NT seq
2982 nt
NT seq
+upstream
nt +downstream
nt
atgccggcgttggcgcgcgacggcggccagctgccgctgctcgttgttttttctgcaatg
atatttgggactattacaaatcaagatctgcctgtgatcaagtgtgttttaatcaatcat
aagaacaatgattcatcagtggggaagtcatcatcatatcccatggtatcagaatccccg
gaagacctcgggtgtgcgttgagaccccagagctcagggacagtgtacgaagctgccgct
gtggaagtggatgtatctgcttccatcacactgcaagtgctggtcgacgccccagggaac
atttcctgtctctgggtctttaagcacagctccctgaattgccagccacattttgattta
caaaacagaggagttgtttccatggtcattttgaaaatgacagaaacccaagctggagaa
tacctactttttattcagagtgaagctaccaattacacaatattgtttacagtgagtata
agaaataccctgctttacacattaagaagaccttactttagaaaaatggaaaaccaggac
gccctggtctgcatatctgagagcgttccagagccgatcgtggaatgggtgctttgcgat
tcacagggggaaagctgtaaagaagaaagtccagctgttgttaaaaaggaggaaaaagtg
cttcatgaattatttgggacggacataaggtgctgtgccagaaatgaactgggcagggaa
tgcaccaggctgttcacaatagatctaaatcaaactcctcagaccacattgccacaatta
tttcttaaagtaggggaacccttatggataaggtgcaaagctgttcatgtgaaccatgga
ttcgggctcacctgggaattagaaaacaaagcactcgaggagggcaactactttgagatg
agtacctattcaacaaacagaactatgatacggattctgtttgcttttgtatcatcagtg
gcaagaaacgacaccggatactacacttgttcctcttcaaagcatcccagtcaatcagct
ttggttaccatcgtagaaaagggatttataaatgctaccaattcaagtgaagattatgaa
attgaccaatatgaagagttttgtttttctgtcaggtttaaagcctacccacaaatcaga
tgtacgtggaccttctctcgaaaatcatttccttgtgagcaaaagggtcttgataacgga
tacagcatatccaagttttgcaatcataagcaccagccaggagaatatatattccatgca
gaaaatgatgatgcccaatttaccaaaatgttcacgctgaatataagaaggaaacctcaa
gtgctcgcagaagcatcggcaagtcaggcgtcctgtttctcggatggatacccattacca
tcttggacctggaagaagtgttcagacaagtctcccaactgcacagaagagatcacagaa
ggagtctggaatagaaaggctaacagaaaagtgtttggacagtgggtgtcgagcagtact
ctaaacatgagtgaagccataaaagggttcctggtcaagtgctgtgcatacaattccctt
ggcacatcttgtgagacgatccttttaaactctccaggccccttccctttcatccaagac
aacatctcattctatgcaacaattggtgtttgtctcctcttcattgtcgttttaaccctg
ctaatttgtcacaagtacaaaaagcaatttaggtatgaaagccagctacagatggtacag
gtgaccggctcctcagataatgagtacttctacgttgatttcagagaatatgaatatgat
ctcaaatgggagtttccaagagaaaatttagagtttgggaaggtactaggatcaggtgct
tttggaaaagtgatgaacgcaacagcttatggaattagcaaaacaggagtctcaatccag
gttgccgtcaaaatgctgaaagaaaaagcagacagctctgaaagagaggcactcatgtca
gaactcaagatgatgacccagctgggaagccacgagaatattgtgaacctgctgggggcg
tgcacactgtcaggaccaatttacttgatttttgaatactgttgctatggtgatcttctc
aactatctaagaagtaaaagagaaaaatttcacaggacttggacagagattttcaaggaa
cacaatttcagtttttaccccactttccaatcacatccaaattccagcatgcctggttca
agagaagttcagatacacccggactcggatcaaatctcagggcttcatgggaattcattt
cactctgaagatgaaattgaatatgaaaaccaaaaaaggctggaagaagaggaggacttg
aatgtgcttacatttgaagatcttctttgctttgcatatcaagttgccaaaggaatggaa
tttctggaatttaagtcgtgtgttcacagagacctggccgccaggaacgtgcttgtcacc
cacgggaaagtggtgaagatatgtgactttggattggctcgagatatcatgagtgattcc
aactatgttgtcaggggcaatgcccgtctgcctgtaaaatggatggcccccgaaagcctg
tttgaaggcatctacaccattaagagtgatgtctggtcatatggaatattactgtgggaa
atcttctcacttggtgtgaatccttaccctggcattccggttgatgctaacttctacaaa
ctgattcaaaatggatttaaaatggatcagccattttatgctacagaagaaatatacatt
ataatgcaatcctgctgggcttttgactcaaggaaacggccatccttccctaatttgact
tcgtttttaggatgtcagctggcagatgcagaagaagcgatgtatcagaatgtggatggc
cgtgtttcggaatgtcctcacacctaccaaaacaggcgacctttcagcagagagatggat
ttggggctactctctccgcaggctcaggtcgaagattcgtag
DBGET
integrated database retrieval system
