Entry |
|
Name |
Cabazitaxel acetonate (JAN); Cabazitaxel acetone; Jevtana (TN) |
Product |
|
Formula |
C45H57NO14. C3H6O
|
Exact mass |
893.4198
|
Mol weight |
894.0115
|
Structure |

|
Simcomp |
|
Class |
Metabolizing enzyme substrate
DG01633 CYP3A substrate
|
Remark |
Therapeutic category: | 4240 |
Product (DG00695): | D10452<JP/US> |
|
Efficacy |
Antineoplastic, Tubulin depolymerization inhibitor |
Disease |
|
Comment |
Taxane derivative
|
Target |
|
Pathway |
|
Metabolism |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CD Taxanes
L01CD04 Cabazitaxel
D10452 Cabazitaxel acetonate (JAN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Cabazitaxel
D10452 Cabazitaxel acetonate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D10452 Cabazitaxel acetonate (JAN)
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D10452 Cabazitaxel acetonate (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10452
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10452
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10452
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10452
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10452
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 64
1 C1y C 17.1500 -14.0700
2 C1z C 18.2700 -14.7000
3 C1y C 16.3800 -14.9100
4 C1z C 17.1500 -12.7400
5 C1y C 19.3900 -14.0700
6 C1x C 19.4600 -15.4000
7 O7a O 18.2700 -16.9400
8 C1z C 14.0000 -14.9100
9 O7a O 16.3800 -17.2200
10 C5x C 15.5400 -11.7600
11 C1y C 18.2700 -12.1800
12 O2x O 20.4400 -14.7700
13 C1x C 19.3900 -12.7400
14 C7a C 19.4600 -17.6400
15 C1z C 14.0000 -13.5800
16 C1x C 12.8800 -15.5400
17 O1a O 14.0000 -16.1000
18 C7a C 15.2600 -17.8500
19 C1y C 12.8800 -11.7600
20 O5x O 15.5400 -10.3600
21 C1a C 20.6500 -16.9400
22 O6a O 19.4600 -19.0400
23 C2y C 12.8800 -12.9500
24 C1a C 14.9800 -12.6000
25 C1a C 14.9800 -14.0700
26 C1y C 11.7600 -14.9100
27 C8y C 15.2600 -19.1100
28 O6a O 14.2800 -17.1500
29 C2y C 11.7600 -13.5800
30 O7a O 10.3600 -15.6100
31 C1a C 10.7100 -12.6700
32 C7a C 9.1700 -14.9800
33 C1c C 8.0500 -15.6100
34 O6a O 9.1700 -13.6500
35 C1c C 6.9300 -14.9800
36 O1a O 8.0500 -16.9400
37 C8y C 5.7400 -15.6100
38 N1b N 6.9300 -13.6500
39 C8x C 4.6200 -14.9800
40 C8x C 5.7400 -16.9400
41 C7a C 5.7400 -12.9500
42 C8x C 3.5000 -15.6100
43 C8x C 4.6200 -17.6400
44 O7a O 5.7400 -11.6900
45 O6a O 4.6200 -13.6500
46 C8x C 3.5000 -16.9400
47 C1d C 4.5500 -11.0600
48 C1a C 4.5500 -9.6600
49 C1a C 3.4300 -11.6900
50 C1a C 3.4300 -10.3600
51 C8x C 14.1400 -19.7400
52 C8x C 14.1400 -21.1400
53 C8x C 15.2600 -21.8400
54 C8x C 16.4500 -21.2100
55 C8x C 16.4500 -19.8100
56 O2a O 18.2700 -10.7800
57 C1a C 19.4600 -10.0800
58 C1a C 17.0100 -11.3400
59 O2a O 11.6200 -11.0600
60 C1a C 11.6200 -9.6600
61 C5a C 25.9700 -15.3300
62 C1a C 27.1824 -16.0300
63 C1a C 24.7576 -16.0300
64 O5a O 25.9700 -13.9300
BOND 68
1 2 7 1 #Down
2 3 8 1
3 3 9 1 #Down
4 4 10 1
5 4 11 1
6 5 12 1 #Up
7 5 13 1
8 7 14 1
9 8 15 1
10 8 16 1
11 8 17 1 #Up
12 9 18 1
13 10 19 1
14 10 20 2
15 14 21 1
16 14 22 2
17 15 23 1
18 15 24 1
19 15 25 1
20 16 26 1
21 18 27 1
22 18 28 2
23 23 29 2
24 26 30 1 #Down
25 29 31 1
26 30 32 1
27 32 33 1
28 32 34 2
29 33 35 1
30 33 36 1 #Down
31 35 37 1
32 35 38 1 #Down
33 37 39 2
34 37 40 1
35 38 41 1
36 39 42 1
37 40 43 2
38 41 44 1
39 41 45 2
40 42 46 2
41 6 12 1
42 11 13 1
43 19 23 1
44 26 29 1
45 43 46 1
46 44 47 1
47 1 2 1
48 47 48 1
49 1 3 1
50 47 49 1
51 1 4 1
52 47 50 1
53 2 5 1
54 2 6 1 #Up
55 27 51 2
56 51 52 1
57 52 53 2
58 53 54 1
59 54 55 2
60 27 55 1
61 11 56 1 #Up
62 56 57 1
63 4 58 1 #Up
64 19 59 1 #Up
65 59 60 1
66 61 62 1
67 61 63 1
68 61 64 2
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