KEGG   DRUG: FinerenoneHelp
Entry
D10633                      Drug                                   

Name
Finerenone (JAN/USAN/INN)
Formula
C21H22N4O3
Exact mass
378.1692
Mol weight
378.4244
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01885  Potassium-sparing diuretic
Efficacy
Diuretic, Aldosterone antagonist
Comment
Treatment of chronic heart failure and diabetic nephropathy
Target
NR3C2 (MR) [HSA:4306] [KO:K08555]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C2 (MR)
     D10633  Finerenone (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1050477-31-0
PubChem: 254741594
ChEMBL: CHEMBL2181927
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8x C    15.0895  -12.3379
            2   N5x N    15.0895  -13.7090
            3   C8y C    16.2767  -14.3945
            4   C8y C    17.4642  -13.7090
            5   C8y C    17.4642  -12.3379
            6   C8y C    16.2767  -11.6524
            7   C1y C    18.6515  -14.3945
            8   C2y C    19.8388  -13.7090
            9   C2y C    19.8388  -12.3379
            10  N1x N    18.6515  -11.6524
            11  C1a C    16.2767  -10.2814
            12  C1a C    21.0262  -11.6524
            13  O2a O    16.2767  -15.7655
            14  C5a C    21.0262  -14.3945
            15  N1a N    22.2135  -13.7090
            16  O5a O    21.0262  -15.6969
            17  C8y C    18.6515  -16.5880
            18  C8x C    17.4662  -17.2724
            19  C8x C    17.4662  -18.6434
            20  C8y C    18.6534  -19.3289
            21  C8x C    19.8388  -18.6446
            22  C8y C    19.8388  -17.2736
            23  O2a O    21.0260  -16.6687
            24  C1a C    22.2599  -17.3078
            25  C3b C    18.6534  -20.7000
            26  N3a N    18.6534  -22.0710
            27  C1b C    15.0960  -16.4473
            28  C1a C    15.0960  -17.8473
BOND        30
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    6  11 1
            13    9  12 1
            14    3  13 1
            15    8  14 1
            16   14  15 1
            17   14  16 2
            18    7  17 1 #Up
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   22  23 1
            26   23  24 1
            27   20  25 1
            28   25  26 3
            29   13  27 1
            30   27  28 1

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