KEGG   DRUG: ErdafitinibHelp
Entry
D10927                      Drug                                   

Name
Erdafitinib (USAN/INN);
Balversa (TN)
Product
Formula
C25H30N6O2
Exact mass
446.243
Mol weight
446.5447
Structure
Mol fileKCF fileDB search
Remark
Product: D10927<US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Urothelial carcinoma [DS:H00022]
Comment
Treatment of cancer
Target
  Pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05219  Bladder cancer
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243], SLC22A2 [HSA:6582]
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR
     D10927  Erdafitinib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10927
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10927
BRITE hierarchy
Other DBs
CAS: 1346242-81-6
PubChem: 342581784
ChEMBL: CHEMBL3545376
PDB-CCD: 5SF[PDBj]
LinkDB All DBs
KCF data Show

ATOM        33
            1   C8y C     9.7300  -15.3300
            2   C8y C     9.7300  -16.7300
            3   C8x C    10.9200  -17.4300
            4   C8x C    12.1800  -16.7300
            5   C8y C    12.1800  -15.3300
            6   C8x C    10.9200  -14.6300
            7   N5x N     8.5400  -14.6300
            8   C8y C     7.2800  -15.3300
            9   C8x C     7.2800  -16.7300
            10  N5x N     8.5400  -17.4300
            11  C8y C     6.0900  -14.6300
            12  C8x C     5.9500  -13.2300
            13  N5x N     4.5500  -12.9500
            14  N4y N     3.8500  -14.1400
            15  C8x C     4.8300  -15.1900
            16  C1a C     2.4500  -14.2800
            17  N1c N    13.3700  -14.6300
            18  C1b C    14.6300  -15.3300
            19  C1b C    15.8200  -14.6300
            20  N1b N    17.0100  -15.3300
            21  C1c C    18.2700  -14.6300
            22  C1a C    19.4600  -15.3300
            23  C8y C    13.3700  -13.2300
            24  C8y C    12.1800  -11.1300
            25  C8x C    12.1800  -12.5300
            26  C8x C    14.6300  -12.5300
            27  C8y C    14.6300  -11.1300
            28  C8x C    13.3700  -10.4300
            29  O2a O    10.9647  -10.4349
            30  O2a O    15.8366  -10.4200
            31  C1a C    17.0463  -11.1053
            32  C1a C     9.7763  -11.1277
            33  C1a C    18.2872  -13.2301
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    8  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 1
            17   11  15 2
            18   14  16 1
            19    5  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   17  23 1
            26   24  25 2
            27   25  23 1
            28   26  27 1
            29   27  28 2
            30   24  28 1
            31   26  23 2
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   29  32 1
            36   21  33 1

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