KEGG   DRUG: Osilodrostat phosphateHelp
Entry
D11062                      Drug                                   

Name
Osilodrostat phosphate (JAN/USAN);
Isturisa (TN)
Formula
C13H10FN3. H3PO4
Exact mass
325.0628
Mol weight
325.2322
Structure
Mol fileKCF fileDB search
Remark
Chemical structure group: DG02839
Efficacy
Antihypertensive, Steroid 11-beta-hydroxylase inhibitor
  Disease
Cushing's disease [DS:H01431]
Comment
Treatment of Cushing's syndrome
Target
CYP11B2 [HSA:1585] [KO:K07433]
  Pathway
hsa00140  Steroid hormone biosynthesis
hsa04925  Aldosterone synthesis and secretion
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP11B2
     D11062  Osilodrostat phosphate (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11062
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11062
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11062
BRITE hierarchy
Other DBs
CAS: 1315449-72-9
ChEMBL: CHEMBL3707393
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C    17.1471  -14.6975
            2   C8y C    17.1471  -16.0973
            3   C8y C    18.3369  -16.7972
            4   C8x C    19.5267  -16.0973
            5   C8x C    19.5267  -14.6975
            6   C8y C    18.3369  -13.9976
            7   C3b C    18.3369  -12.5979
            8   N3a N    18.3369  -11.1981
            9   X   F    15.9573  -16.7972
            10  C1y C    18.3369  -18.1969
            11  C1x C    17.2171  -18.9668
            12  C1x C    17.6370  -20.3666
            13  C8y C    19.0368  -20.3666
            14  N4y N    19.4567  -18.9668
            15  C8x C    20.1566  -21.1364
            16  N5x N    21.3464  -20.3666
            17  C8x C    20.8565  -18.9668
            18  P1b P    24.0800  -16.8000
            19  O1c O    22.6800  -16.8000
            20  O1c O    25.4800  -16.8000
            21  O1c O    24.0800  -18.2000
            22  O1c O    24.0800  -15.4000
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 3
            9     2   9 1
            10   10   3 1 #Down
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   14  17 1
            20   18  19 1
            21   18  20 1
            22   18  21 1
            23   18  22 2

» Japanese version   » Back

DBGET integrated database retrieval system