KEGG   DRUG: Terazosin hydrochloride anhydrous
Entry
D11585                      Drug                                   
Name
Terazosin hydrochloride anhydrous
Product
  Generic
Formula
C19H25N5O4. HCl
Exact mass
423.1673
Mol weight
423.8938
Structure
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
 DG03231  Antihypertensive
Remark
ATC code: G04CA03
Chemical structure group: DG00491
Product (DG00491): D00610<JP/US> D11585<US>
Efficacy
Antidysuria, Antihypertensive, alpha1-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Prazosin derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA03 Terazosin
      D11585  Terazosin hydrochloride anhydrous <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00491  Terazosin
      D11585  Terazosin hydrochloride anhydrous
  DG03231  Antihypertensive
   DG00491  Terazosin
    D11585  Terazosin hydrochloride anhydrous
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D11585  Terazosin hydrochloride anhydrous
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D11585  Terazosin hydrochloride anhydrous <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00491  Terazosin
  DG03231  Antihypertensive
   DG00491  Terazosin
Other DBs
CAS: 63074-08-8
PubChem: 405226452
LinkDB
KCF data

ATOM        29
            1   C8y C    18.0600  -17.9200
            2   C8y C    18.0600  -16.5200
            3   C8x C    19.2500  -18.6200
            4   C8y C    16.8700  -18.6200
            5   N5x N    16.8700  -15.8200
            6   C8x C    19.2500  -15.8200
            7   C8y C    20.5100  -17.9200
            8   N5x N    15.6100  -17.9200
            9   N1a N    16.8700  -20.0200
            10  C8y C    15.6100  -16.5200
            11  C8y C    20.5100  -16.5200
            12  O2a O    21.7000  -18.6200
            13  N1y N    14.4200  -15.8200
            14  O2a O    21.7000  -15.8200
            15  C1a C    22.8900  -17.9200
            16  C1x C    14.4200  -14.4200
            17  C1x C    13.2300  -16.5200
            18  C1a C    22.8900  -16.5200
            19  C1x C    13.2300  -13.7200
            20  C1x C    11.9700  -15.8200
            21  N1y N    11.9700  -14.4200
            22  C5a C    10.7800  -13.7200
            23  C1y C     9.5900  -14.4200
            24  O5a O    10.7800  -12.3200
            25  C1x C     9.5900  -15.8200
            26  O2x O     8.2600  -14.0000
            27  C1x C     7.4200  -15.1200
            28  C1x C     8.2600  -16.2400
            29  X   Cl   23.4500  -12.2500
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21    7  11 1
            22    8  10 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 2
            27   23  25 1
            28   23  26 1
            29   26  27 1
            30   27  28 1
            31   25  28 1

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