KEGG   DRUG: Acoramidis
Entry
D11972                      Drug                                   
Name
Acoramidis (USAN)
Formula
C15H17FN2O3
Exact mass
292.1223
Mol weight
292.30
Structure
Class
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03183  UGT1A1 substrate
  DG03188  UGT1A9 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: C01EB25
Chemical structure group: DG03143
Product (DG03143): D11973<JP/US>
Efficacy
Amyloidogenesis suppressant
Comment
Treatment of patients with transthyretin amyloidosis
Target
TTR [HSA:7276] [KO:K20731]
  Pathway
hsa04918  Thyroid hormone synthesis
Metabolism
Enzyme: UGT1A9 [HSA:54600], UGT1A1 [HSA:54658], UGT2B7 [HSA:7364]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB25 Acoramidis
      D11972  Acoramidis (USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03183  UGT1A1 substrate
    DG03143  Acoramidis
     D11972  Acoramidis
   DG03188  UGT1A9 substrate
    DG03143  Acoramidis
     D11972  Acoramidis
   DG03190  UGT2B7 substrate
    DG03143  Acoramidis
     D11972  Acoramidis
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Others
    TTR
     D11972  Acoramidis (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11972
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03183  UGT1A1 substrate
    DG03143  Acoramidis
   DG03188  UGT1A9 substrate
    DG03143  Acoramidis
   DG03190  UGT2B7 substrate
    DG03143  Acoramidis
Other DBs
CAS: 1446711-81-4
PubChem: 497620385
PDB-CCD: 16V[PDBj]
LinkDB
KCF data

ATOM        21
            1   C8y C    12.5300  -12.6700
            2   C8y C    12.5300  -14.0700
            3   C8x C    13.7424  -14.7700
            4   C8x C    14.9549  -14.0700
            5   C8y C    14.9549  -12.6700
            6   C8x C    13.7424  -11.9700
            7   C6a C    16.1860  -11.9590
            8   O6a O    17.3912  -12.6547
            9   O6a O    16.1857  -10.5701
            10  X   F    11.3176  -14.7700
            11  O2a O    11.3176  -11.9700
            12  C1b C    10.1221  -12.6604
            13  C1b C     8.9347  -11.9749
            14  C1b C     7.7435  -12.6629
            15  C8y C     6.5540  -11.9762
            16  C8y C     6.6671  -10.5727
            17  N4x N     5.3721  -10.0323
            18  N5x N     4.4580  -11.0969
            19  C8y C     5.1880  -12.2953
            20  C1a C     7.8511   -9.8507
            21  C1a C     4.6365  -13.6102
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    2  10 1
            11    1  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 1
            19   18  19 2
            20   15  19 1
            21   16  20 1
            22   19  21 1

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