KEGG   DRUG: Lazertinib
Entry
D11980                      Drug                                   

Name
Lazertinib (USAN)
Formula
C30H34N8O3
Exact mass
554.2754
Mol weight
554.6428
Structure
Remark
Chemical structure group: DG03205
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Comment
Treatment of non-small cell lung cancer (NSCLC)
Target
EGFR* [HSA_VAR:1956v3] [HSA:1956] [KO:K04361]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR* [HSA_VAR:1956v3]
     D11980  Lazertinib (USAN)
Other DBs
CAS: 1903008-80-9
ChEMBL: CHEMBL4558324
LinkDB
KCF data

ATOM        41
            1   C8x C    19.6000  -16.5200
            2   C8y C    19.6000  -15.1200
            3   C8y C    20.7900  -14.4200
            4   C8x C    22.0500  -15.1200
            5   C8y C    22.0500  -16.5200
            6   C8y C    20.7900  -17.2200
            7   N1y N    23.2400  -17.2200
            8   N1b N    18.4100  -14.4200
            9   O2a O    20.7900  -13.0200
            10  C1x C    24.4300  -16.5200
            11  C1x C    25.6900  -17.2200
            12  O2x O    25.6900  -18.6200
            13  C1x C    24.5000  -19.3200
            14  C1x C    23.2400  -18.6200
            15  N1b N    20.7900  -18.6200
            16  C5a C    19.6000  -19.3200
            17  C2b C    18.4100  -18.6200
            18  O5a O    19.6000  -20.7200
            19  C2a C    17.2200  -19.3200
            20  C1a C    22.0024  -12.3200
            21  C8y C    18.4100  -13.0200
            22  N5x N    19.6224  -12.3200
            23  C8x C    19.6224  -10.9200
            24  C8x C    18.4100  -10.2200
            25  C8y C    17.1976  -10.9200
            26  N5x N    17.1976  -12.3200
            27  N4y N    16.0021  -10.2296
            28  N5x N    16.0060   -8.8202
            29  C8y C    14.6699   -8.3811
            30  C8y C    13.8394   -9.5161
            31  C8x C    14.6622  -10.6566
            32  C8y C    14.2506   -7.0741
            33  C8x C    15.2062   -6.0202
            34  C8x C    14.7782   -4.6872
            35  C8x C    13.4098   -4.3914
            36  C8x C    12.4542   -5.4453
            37  C8x C    12.8822   -6.7783
            38  C1b C    12.4600   -9.5114
            39  N1c N    11.7522  -10.7279
            40  C1a C    10.3601  -10.7232
            41  C1a C    12.4424  -11.9324
BOND        45
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     2   8 1
            9     3   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    7  14 1
            16    6  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 2
            20   17  19 2
            21    9  20 1
            22    8  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   25  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   27  31 1
            35   29  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   35  36 1
            40   36  37 2
            41   32  37 1
            42   30  38 1
            43   38  39 1
            44   39  40 1
            45   39  41 1

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